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What is Reactome ?
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Fgf23 [extracellular region]
Stable Identifier
R-RNO-189891
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
extracellular region
Synonyms
FGF23(25-251), Q8VI82
Locations in the PathwayBrowser
Expand all
Signal Transduction (Rattus norvegicus)
Intracellular signaling by second messengers (Rattus norvegicus)
PIP3 activates AKT signaling (Rattus norvegicus)
Negative regulation of the PI3K/AKT network (Rattus norvegicus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
Activator:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
Activator:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
MAPK family signaling cascades (Rattus norvegicus)
MAPK1/MAPK3 signaling (Rattus norvegicus)
RAF/MAP kinase cascade (Rattus norvegicus)
RAS GEFs promote RAS nucleotide exchange (Rattus norvegicus)
RAS GEFs [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1:p-FRS3 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-SHC1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by FGFR (Rattus norvegicus)
Signaling by FGFR1 (Rattus norvegicus)
Downstream signaling of activated FGFR1 (Rattus norvegicus)
Activated FGFR1 binds FLRT1,2,3 (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1:FLRT [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
FRS-mediated FGFR1 signaling (Rattus norvegicus)
Activated FGFR1 binds FRS2 (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1:FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1 binds FRS3 (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1:FRS3 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1 phosphorylates FRS2 (Rattus norvegicus)
Activated FGFR1:FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1 phosphorylates FRS3 (Rattus norvegicus)
Activated FGFR1:FRS3 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1:p-FRS3 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1:p-FRS bind to PPTN11 (Rattus norvegicus)
Activated FGFR1:p-FRS [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1:p-FRS3 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1:p-FRS3 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1:p-FRS binds GRB2:SOS1 (Rattus norvegicus)
Activated FGFR1:p-FRS [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1:p-FRS3 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1:p-FRS3 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1:p-FRS phosphorylates PPTN11 (Rattus norvegicus)
Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1:p-FRS3 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1:p-FRS3 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1:p-FRS3 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Rattus norvegicus)
Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1:p-FRS3 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
PI-3K cascade:FGFR1 (Rattus norvegicus)
Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Rattus norvegicus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Phospholipase C-mediated cascade: FGFR1 (Rattus norvegicus)
Activated FGFR1 binds PLCG1 (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
activated FGFR1:PLCG1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1 phosphorylates PLCG1 (Rattus norvegicus)
activated FGFR1:PLCG1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
activated FGFR1:p-4Y-PLCG1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
p-4Y-PLCG1 dissociates from activated FGFR1 (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
activated FGFR1:p-4Y-PLCG1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
SHC-mediated cascade:FGFR1 (Rattus norvegicus)
Activated FGFR1 binds SHC1 (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1:SHC1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1 phosphorylates SHC1 (Rattus norvegicus)
Activated FGFR1:SHC1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1:p-SHC1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Rattus norvegicus)
Activated FGFR1:p-SHC1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-SHC1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-SHC1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
FGFR1 ligand binding and activation (Rattus norvegicus)
FGFR1c and Klotho ligand binding and activation (Rattus norvegicus)
Autocatalytic phosphorylation of Klotho-bound FGFR1c (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
FGF23 bound to Klotho and FGFR1c [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
FGFR1c binds to Klotho-bound FGF23 (Rattus norvegicus)
FGF23 bound to Klotho and FGFR1c [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Negative regulation of FGFR1 signaling (Rattus norvegicus)
Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Rattus norvegicus)
Activated FGFR1:FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1:p-8T-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
CBL ubiquitinates FRS2 and FGFR1 (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Ub-Activated FGFR1 complex:Ub-p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Signaling by Insulin receptor (Rattus norvegicus)
Insulin receptor signalling cascade (Rattus norvegicus)
IRS-mediated signalling (Rattus norvegicus)
PI3K Cascade (Rattus norvegicus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Rattus norvegicus)
PI3K-containing complexes [cytosol] (Rattus norvegicus)
Activated FGFR bound to PI3K [cytosol] (Rattus norvegicus)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Rattus norvegicus)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Rattus norvegicus)
IGF1R signaling cascade (Rattus norvegicus)
IRS-related events triggered by IGF1R (Rattus norvegicus)
IRS-mediated signalling (Rattus norvegicus)
PI3K Cascade (Rattus norvegicus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Rattus norvegicus)
PI3K-containing complexes [cytosol] (Rattus norvegicus)
Activated FGFR bound to PI3K [cytosol] (Rattus norvegicus)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Rattus norvegicus)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR:p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR [plasma membrane] (Rattus norvegicus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Rattus norvegicus)
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Fgf23 [extracellular region] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q8VI82
Gene Names
Fgf23
Reference Genes
BioGPS Gene:170583 Fgf23
ENSEMBL:ENSRNOG00000052205
ENSEMBL:ENSRNOG00000066556
ENSEMBL:ENSRNOG00000066556.1 Fgf23
ENSEMBL:ENSRNOG00055010713
ENSEMBL:ENSRNOG00060017634
ENSEMBL:ENSRNOG00065033593
KEGG Gene (Rattus norvegicus):170583 Fgf23
Monarch:170583 Fgf23
NCBI Gene:170583 Fgf23
UCSC:Q8VI82 Fgf23
Reference Transcript
RefSeq:NM_130754.1 Fgf23
Other Identifiers
10859003
1369595_at
1379985_at
170583
17787427
5667768
5764701
5797587
5802767
5947650
6178996
6426138
6692227
A_44_P146675
A_44_P690427
GE1100785
GE1145147
GO:0000165
GO:0005104
GO:0005105
GO:0005576
GO:0005615
GO:0006351
GO:0006355
GO:0006629
GO:0006766
GO:0008083
GO:0008543
GO:0010966
GO:0023052
GO:0030154
GO:0030500
GO:0030502
GO:0030643
GO:0042369
GO:0045668
GO:0045893
GO:0048018
GO:0048856
GO:0055062
GO:0055065
GO:0055074
GO:0070371
GO:0070374
GO:0090080
GO:0098772
GO:1904383
ILMN_1366217
PH_rn_0012169
Participates
as a component of
Klotho bound to FGF23 [plasma membrane] (Rattus norvegicus)
Other forms of this molecule
phospho-Fgf23 [endoplasmic reticulum lumen]
Fgf23 [endoplasmic reticulum lumen]
Fgf23 [Golgi lumen]
Fgf23 [Golgi lumen]
Fgf23 [extracellular region]
Inferred From
FGF23(25-251) [extracellular region]
(Homo sapiens)
Cross References
RefSeq
NP_570110.1
Ensembl
ENSRNOP00000087703
,
ENSRNOG00000066556
,
ENSRNOT00000107111
PRO
Q8VI82
RGD
620178
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