Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
Vav1 [cytosol]
Stable Identifier
R-RNO-195066
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
VAV1, P54100
Locations in the PathwayBrowser
Expand all
Hemostasis (Rattus norvegicus)
Platelet activation, signaling and aggregation (Rattus norvegicus)
GPVI-mediated activation cascade (Rattus norvegicus)
VAV1 is a GEF for Rho/Rac family GTPases (Rattus norvegicus)
PIP3:VAV1,2,3 [plasma membrane] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav1 [cytosol] (Rattus norvegicus)
VAV family:PIP2 [plasma membrane] (Rattus norvegicus)
VAV family [cytosol] (Rattus norvegicus)
Vav1 [cytosol] (Rattus norvegicus)
p-SLP-76 binds VAV (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav1 [cytosol] (Rattus norvegicus)
p-SLP-76:VAV [cytosol] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav1 [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Costimulation by the CD28 family (Rattus norvegicus)
CD28 co-stimulation (Rattus norvegicus)
CD28 dependent Vav1 pathway (Rattus norvegicus)
Activation of Vav1 (Rattus norvegicus)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Rattus norvegicus)
Vav1 [cytosol] (Rattus norvegicus)
Translocation of Vav1 to CD28 (Rattus norvegicus)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Rattus norvegicus)
Vav1 [cytosol] (Rattus norvegicus)
Vav1 [cytosol] (Rattus norvegicus)
Signaling by the B Cell Receptor (BCR) (Rattus norvegicus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Rattus norvegicus)
BTK binds BTK inhibitors (Rattus norvegicus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Rattus norvegicus)
Vav1 [cytosol] (Rattus norvegicus)
BTK:BTK inhibitors [plasma membrane] (Rattus norvegicus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Rattus norvegicus)
Vav1 [cytosol] (Rattus norvegicus)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Rattus norvegicus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Rattus norvegicus)
Vav1 [cytosol] (Rattus norvegicus)
Vav1 [cytosol] (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Rattus norvegicus)
IL3 stimulation induces Vav binding to Tec kinase (Rattus norvegicus)
TEC:VAV1 [cytosol] (Rattus norvegicus)
Vav1 [cytosol] (Rattus norvegicus)
Vav1 [cytosol] (Rattus norvegicus)
Regulation of signaling by CBL (Rattus norvegicus)
CBL binds VAV (Rattus norvegicus)
Vav1 [cytosol] (Rattus norvegicus)
p(Y700,731,774)-CBL:VAV1 [cytosol] (Rattus norvegicus)
Vav1 [cytosol] (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
Fc epsilon receptor (FCERI) signaling (Rattus norvegicus)
FCERI mediated Ca+2 mobilization (Rattus norvegicus)
Autophosphorylation of BTK/ITK (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav1 [cytosol] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav1 [cytosol] (Rattus norvegicus)
Hydrolysis of PIP2 by PLCG (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav1 [cytosol] (Rattus norvegicus)
Phosphorylation of TEC kinases by p-SYK (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav1 [cytosol] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav1 [cytosol] (Rattus norvegicus)
FCERI mediated MAPK activation (Rattus norvegicus)
Phosphorylation and activation of VAV (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav1 [cytosol] (Rattus norvegicus)
Recruitment of VAV to p-SLP-76 (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav1 [cytosol] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav1 [cytosol] (Rattus norvegicus)
Fcgamma receptor (FCGR) dependent phagocytosis (Rattus norvegicus)
Regulation of actin dynamics for phagocytic cup formation (Rattus norvegicus)
Phosphorylation of VAV (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav1 [cytosol] (Rattus norvegicus)
Recruitment of VAV1 to p-6Y-SYK (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav1 [cytosol] (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav1 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Death Receptor Signaling (Rattus norvegicus)
p75 NTR receptor-mediated signalling (Rattus norvegicus)
Cell death signalling via NRAGE, NRIF and NADE (Rattus norvegicus)
NRAGE signals death through JNK (Rattus norvegicus)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Rattus norvegicus)
GEFs [cytosol] (Rattus norvegicus)
Vav1 [cytosol] (Rattus norvegicus)
Signaling by Erythropoietin (Rattus norvegicus)
Erythropoietin activates RAS (Rattus norvegicus)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Rattus norvegicus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:VAV1 [plasma membrane] (Rattus norvegicus)
GRB2-1:VAV1 [cytosol] (Rattus norvegicus)
Vav1 [cytosol] (Rattus norvegicus)
GRB2-1:VAV1 [cytosol] (Rattus norvegicus)
Vav1 [cytosol] (Rattus norvegicus)
Signaling by GPCR (Rattus norvegicus)
GPCR downstream signalling (Rattus norvegicus)
G alpha (12/13) signalling events (Rattus norvegicus)
GEFs activate RhoA,B,C (Rattus norvegicus)
GEFs [cytosol] (Rattus norvegicus)
Vav1 [cytosol] (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by SCF-KIT (Rattus norvegicus)
Phosphorylation and activation of VAV1 (Rattus norvegicus)
Vav1 [cytosol] (Rattus norvegicus)
Signaling by VEGF (Rattus norvegicus)
VEGFA-VEGFR2 Pathway (Rattus norvegicus)
Src kinases phosphorylate VAV (Rattus norvegicus)
PIP3:VAV1,2,3 [plasma membrane] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav1 [cytosol] (Rattus norvegicus)
VAV exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)
VAV family [cytosol] (Rattus norvegicus)
Vav1 [cytosol] (Rattus norvegicus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Rattus norvegicus)
Signaling by Rho GTPases (Rattus norvegicus)
RHO GTPase cycle (Rattus norvegicus)
RAC1 GTPase cycle (Rattus norvegicus)
RAC1 GEFs activate RAC1 (Rattus norvegicus)
RAC1 GEFs [cytosol] (Rattus norvegicus)
Vav1 [cytosol] (Rattus norvegicus)
RAC2 GTPase cycle (Rattus norvegicus)
RAC2 GEFs activate RAC2 (Rattus norvegicus)
RAC2 GEFs [cytosol] (Rattus norvegicus)
Vav1 [cytosol] (Rattus norvegicus)
RHOA GTPase cycle (Rattus norvegicus)
RHOA GEFs activate RHOA (Rattus norvegicus)
RHOA GEFs [cytosol] (Rattus norvegicus)
Vav1 [cytosol] (Rattus norvegicus)
RHOG GTPase cycle (Rattus norvegicus)
RHOG GEFs activate RHOG (Rattus norvegicus)
RHOG GEFs [cytosol] (Rattus norvegicus)
Vav1 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P54100
Gene Names
Vav1
Reference Genes
ENSEMBL:ENSRNOG00000050430
Participates
as a component of
GRB2-1:VAV1 [cytosol] (Rattus norvegicus)
TEC:VAV1 [cytosol] (Rattus norvegicus)
p(Y700,731,774)-CBL:VAV1 [cytosol] (Rattus norvegicus)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Rattus norvegicus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Rattus norvegicus)
as a member of
RHOA GEFs [cytosol] (Rattus norvegicus)
RAC2 GEFs [cytosol] (Rattus norvegicus)
RAC1 GEFs [cytosol] (Rattus norvegicus)
RHOG GEFs [cytosol] (Rattus norvegicus)
GEFs [cytosol] (Rattus norvegicus)
VAV family [cytosol] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
as an input of
IL3 stimulation induces Vav binding to Tec kinase (Rattus norvegicus)
CBL binds VAV (Rattus norvegicus)
Phosphorylation and activation of VAV1 (Rattus norvegicus)
Translocation of Vav1 to CD28 (Rattus norvegicus)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Rattus norvegicus)
Other forms of this molecule
phospho-Vav1 [plasma membrane]
phospho-Vav1 [cytosol]
Vav1 [plasma membrane]
Inferred From
VAV1 [cytosol]
(Homo sapiens)
Cross References
PRO
P54100
RGD
3951
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
