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Pik3r1 [plasma membrane]
Stable Identifier
R-RNO-198365
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
plasma membrane
Synonyms
PIK3R1, Q63787
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Signaling by the B Cell Receptor (BCR) (Rattus norvegicus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Rattus norvegicus)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Rattus norvegicus)
BCAP Signalosome [plasma membrane] (Rattus norvegicus)
PIK3CD:PIK3R1 [plasma membrane] (Rattus norvegicus)
Pik3r1 [plasma membrane] (Rattus norvegicus)
PIK3CD:PIK3R1 [plasma membrane] (Rattus norvegicus)
Pik3r1 [plasma membrane] (Rattus norvegicus)
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Rattus norvegicus)
CD19 Signalosome [plasma membrane] (Rattus norvegicus)
PIK3CD:PIK3R1 [plasma membrane] (Rattus norvegicus)
Pik3r1 [plasma membrane] (Rattus norvegicus)
PIK3CD:PIK3R1 [plasma membrane] (Rattus norvegicus)
Pik3r1 [plasma membrane] (Rattus norvegicus)
p-CD19:VAV binds PI3K and GRB2 (Rattus norvegicus)
CD19 Signalosome [plasma membrane] (Rattus norvegicus)
PIK3CD:PIK3R1 [plasma membrane] (Rattus norvegicus)
Pik3r1 [plasma membrane] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Intracellular signaling by second messengers (Rattus norvegicus)
PIP3 activates AKT signaling (Rattus norvegicus)
Negative regulation of the PI3K/AKT network (Rattus norvegicus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
Activator:PI3K [plasma membrane] (Rattus norvegicus)
BCAP Signalosome [plasma membrane] (Rattus norvegicus)
PIK3CD:PIK3R1 [plasma membrane] (Rattus norvegicus)
Pik3r1 [plasma membrane] (Rattus norvegicus)
CD19 Signalosome [plasma membrane] (Rattus norvegicus)
PIK3CD:PIK3R1 [plasma membrane] (Rattus norvegicus)
Pik3r1 [plasma membrane] (Rattus norvegicus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Pik3r1 [plasma membrane] (Rattus norvegicus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Rattus norvegicus)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Rattus norvegicus)
Pik3r1 [plasma membrane] (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
Activator:PI3K [plasma membrane] (Rattus norvegicus)
BCAP Signalosome [plasma membrane] (Rattus norvegicus)
PIK3CD:PIK3R1 [plasma membrane] (Rattus norvegicus)
Pik3r1 [plasma membrane] (Rattus norvegicus)
CD19 Signalosome [plasma membrane] (Rattus norvegicus)
PIK3CD:PIK3R1 [plasma membrane] (Rattus norvegicus)
Pik3r1 [plasma membrane] (Rattus norvegicus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Pik3r1 [plasma membrane] (Rattus norvegicus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Rattus norvegicus)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Rattus norvegicus)
Pik3r1 [plasma membrane] (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by ERBB2 (Rattus norvegicus)
PI3K events in ERBB2 signaling (Rattus norvegicus)
Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Rattus norvegicus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Rattus norvegicus)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Rattus norvegicus)
Pik3r1 [plasma membrane] (Rattus norvegicus)
Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Rattus norvegicus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Pik3r1 [plasma membrane] (Rattus norvegicus)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Rattus norvegicus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Pik3r1 [plasma membrane] (Rattus norvegicus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Rattus norvegicus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Rattus norvegicus)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Rattus norvegicus)
Pik3r1 [plasma membrane] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q63787 Pik3r1
Gene Names
Pik3r1
Chain
initiator methionine:, chain:2-724
Reference Genes
BioGPS Gene:25513 Pik3r1
KEGG Gene (Rattus norvegicus):25513 Pik3r1
Monarch:25513 Pik3r1
NCBI Gene:25513 Pik3r1
UCSC:Q63787 Pik3r1
Reference Transcript
RefSeq:NM_013005.1 Pik3r1
Participates
as a component of
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Rattus norvegicus)
PIK3CD:PIK3R1 [plasma membrane] (Rattus norvegicus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Other forms of this molecule
Pik3r1 [cytosol]
Pi3k-p85 [cytosol]
Pik3r1 [cytosol]
Inferred From
PIK3R1 [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
NP_037137.1
PRO
Q63787
RGD
3329
PDB
1FU5
,
1FU6
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62813 Gabra1
2
Gabra1 [plasma membrane]
(R-RNO-8856427)
GABRA1 [plasma membrane]
(R-RNO-975262)
0.591
4
UniProt:P35570 Irs1
7
Irs1 [cytosol]
(R-RNO-1168867)
phospho-Irs1 [plasma membrane]
(R-RNO-2445090)
Irs1 [plasma membrane]
(R-RNO-2425392)
p-Y-Irs1 [cytosol]
(R-RNO-112362)
Irs1 [cytosol]
(R-RNO-74769)
phospho-Irs1 [cytosol]
(R-RNO-74772)
phospho-Irs1 [plasma membrane]
(R-RNO-198366)
0.589
2
UniProt:P18545 PDE6G
2
PDE6G [photoreceptor disc membrane]
(R-HSA-52449)
PDE6G [plasma membrane]
(R-HSA-4085973)
0.527
2
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