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Pleiotrophin [extracellular region]
Stable Identifier
R-RNO-201507
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
extracellular region
Synonyms
PTN_RAT, Ptn
Locations in the PathwayBrowser
Expand all
Signal Transduction (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by ALK (Rattus norvegicus)
(PTN,MDK):PTPRZ oligomerizes (Rattus norvegicus)
(PTN,MDK):PTPRZ [plasma membrane] (Rattus norvegicus)
PTN,MDK [extracellular region] (Rattus norvegicus)
Pleiotrophin [extracellular region] (Rattus norvegicus)
(PTN,MDK):PTPRZ oligomers [plasma membrane] (Rattus norvegicus)
(PTN,MDK):PTPRZ [plasma membrane] (Rattus norvegicus)
PTN,MDK [extracellular region] (Rattus norvegicus)
Pleiotrophin [extracellular region] (Rattus norvegicus)
(PTN/MDK):ALK dimer binds type I ALK-binding TKIs (Rattus norvegicus)
(PTN,MDK):ALK dimer [plasma membrane] (Rattus norvegicus)
PTN:ALK dimer [plasma membrane] (Rattus norvegicus)
Pleiotrophin [extracellular region] (Rattus norvegicus)
(PTN/MDK):ALK dimer:type I ALK binding TKI [plasma membrane] (Rattus norvegicus)
(PTN,MDK):ALK dimer [plasma membrane] (Rattus norvegicus)
PTN:ALK dimer [plasma membrane] (Rattus norvegicus)
Pleiotrophin [extracellular region] (Rattus norvegicus)
ALK autophosphorylation downstream of PTN and MDK (Rattus norvegicus)
(PTN,MDK):ALK dimer [plasma membrane] (Rattus norvegicus)
PTN:ALK dimer [plasma membrane] (Rattus norvegicus)
Pleiotrophin [extracellular region] (Rattus norvegicus)
(PTN/MDK):ALK dimer:type I ALK binding TKI [plasma membrane] (Rattus norvegicus)
(PTN,MDK):ALK dimer [plasma membrane] (Rattus norvegicus)
PTN:ALK dimer [plasma membrane] (Rattus norvegicus)
Pleiotrophin [extracellular region] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
PTN:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Pleiotrophin [extracellular region] (Rattus norvegicus)
ALK binds ligand pleiotrophin (PTN) (Rattus norvegicus)
PTN:ALK receptor [plasma membrane] (Rattus norvegicus)
Pleiotrophin [extracellular region] (Rattus norvegicus)
Pleiotrophin [extracellular region] (Rattus norvegicus)
Active ALK binds JAK3 (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
PTN:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Pleiotrophin [extracellular region] (Rattus norvegicus)
Active ALK:JAK3 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
PTN:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Pleiotrophin [extracellular region] (Rattus norvegicus)
Active ALK binds PLCG1 (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
PTN:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Pleiotrophin [extracellular region] (Rattus norvegicus)
Active ALK:PLCG1 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
PTN:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Pleiotrophin [extracellular region] (Rattus norvegicus)
Active ALK binds SHC1 (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
PTN:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Pleiotrophin [extracellular region] (Rattus norvegicus)
Active ALK dimer:SHC1 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
PTN:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Pleiotrophin [extracellular region] (Rattus norvegicus)
Active ALK dimer binds IRS1 (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
PTN:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Pleiotrophin [extracellular region] (Rattus norvegicus)
Active ALK:IRS1 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
PTN:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Pleiotrophin [extracellular region] (Rattus norvegicus)
Active ALK phosphorylates IRS1 (Rattus norvegicus)
Active ALK:IRS1 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
PTN:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Pleiotrophin [extracellular region] (Rattus norvegicus)
Active ALK:pY-IRS1 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
PTN:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Pleiotrophin [extracellular region] (Rattus norvegicus)
Active ALK phosphorylates JAK3 (Rattus norvegicus)
Active ALK:JAK3 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
PTN:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Pleiotrophin [extracellular region] (Rattus norvegicus)
Active ALK:p-Y980 JAK3 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
PTN:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Pleiotrophin [extracellular region] (Rattus norvegicus)
Active ALK phosphorylates PLCG1 (Rattus norvegicus)
Active ALK:PLCG1 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
PTN:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Pleiotrophin [extracellular region] (Rattus norvegicus)
active ALK:p-4Y PLCG1 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
PTN:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Pleiotrophin [extracellular region] (Rattus norvegicus)
Active ALK phosphorylates SHC1 (Rattus norvegicus)
Active ALK dimer:SHC1 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
PTN:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Pleiotrophin [extracellular region] (Rattus norvegicus)
Active ALK:p-3Y SHC1 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
PTN:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Pleiotrophin [extracellular region] (Rattus norvegicus)
Active ALK recruits PI3K (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
PTN:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Pleiotrophin [extracellular region] (Rattus norvegicus)
active ALK:PI3K [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
PTN:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Pleiotrophin [extracellular region] (Rattus norvegicus)
PI3K synthesizes PIP3 downstream of ALK (Rattus norvegicus)
active ALK:PI3K [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
PTN:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Pleiotrophin [extracellular region] (Rattus norvegicus)
PTN and MDK bind to PTPRZ (Rattus norvegicus)
(PTN,MDK):PTPRZ [plasma membrane] (Rattus norvegicus)
PTN,MDK [extracellular region] (Rattus norvegicus)
Pleiotrophin [extracellular region] (Rattus norvegicus)
PTN,MDK [extracellular region] (Rattus norvegicus)
Pleiotrophin [extracellular region] (Rattus norvegicus)
PTPN6 dephosphorylates JAK3 (Rattus norvegicus)
Active ALK:JAK3 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
PTN:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Pleiotrophin [extracellular region] (Rattus norvegicus)
Active ALK:p-Y980 JAK3 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
PTN:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Pleiotrophin [extracellular region] (Rattus norvegicus)
PTPRZ dephosphorylates ligand-bound ALK dimers (Rattus norvegicus)
(PTN,MDK):ALK dimer [plasma membrane] (Rattus norvegicus)
PTN:ALK dimer [plasma membrane] (Rattus norvegicus)
Pleiotrophin [extracellular region] (Rattus norvegicus)
(PTN,MDK):PTPRZ oligomers [plasma membrane] (Rattus norvegicus)
(PTN,MDK):PTPRZ [plasma membrane] (Rattus norvegicus)
PTN,MDK [extracellular region] (Rattus norvegicus)
Pleiotrophin [extracellular region] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
PTN:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Pleiotrophin [extracellular region] (Rattus norvegicus)
STAT3 is phosphorylated downstream of active ALK (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
PTN:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Pleiotrophin [extracellular region] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P63090 Ptn
Gene Names
Ptn
Chain
signal peptide:1-32, chain:33-168
Reference Genes
BioGPS Gene:24924 Ptn
ENSEMBL:ENSRNOG00000011946 Ptn
KEGG Gene (Rattus norvegicus):24924 Ptn
Monarch:24924 Ptn
NCBI Gene:24924 Ptn
UCSC:P63090 Ptn
Reference Transcript
RefSeq:NM_017066.2 Ptn
Other Identifiers
10861835
1369968_at
17790596
24924
5782578
5870449
6115374
6335801
6535538
6559836
6688493
A_43_P11804
GE20315
GO:0000003
GO:0000902
GO:0001503
GO:0002232
GO:0002376
GO:0002690
GO:0003674
GO:0004864
GO:0005178
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005783
GO:0006464
GO:0006950
GO:0007165
GO:0007229
GO:0007267
GO:0007406
GO:0007612
GO:0007613
GO:0008083
GO:0008150
GO:0008201
GO:0008283
GO:0008284
GO:0010996
GO:0019899
GO:0019901
GO:0030154
GO:0030234
GO:0030282
GO:0030501
GO:0031641
GO:0032991
GO:0035374
GO:0040007
GO:0040011
GO:0042246
GO:0043113
GO:0043167
GO:0043226
GO:0043932
GO:0044849
GO:0045597
GO:0046697
GO:0048167
GO:0048477
GO:0048714
GO:0048856
GO:0048870
GO:0050877
GO:0140059
GO:1900006
GO:1900272
GO:1903706
GO:2000036
GO:2000347
GO:2000738
ILMN_1365825
PH_rn_0014482
rc_AI102795_at
Participates
as a member of
PTN,MDK [extracellular region] (Rattus norvegicus)
as a component of
PTN:ALK dimer [plasma membrane] (Rattus norvegicus)
PTN:ALK [plasma membrane] (Rattus norvegicus)
PTN:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
PTN:ALK receptor [plasma membrane] (Rattus norvegicus)
PTN:ALK dimer [plasma membrane] (Rattus norvegicus)
as an input of
ALK binds ligand pleiotrophin (PTN) (Rattus norvegicus)
Inferred From
PTN [extracellular region]
(Homo sapiens)
Cross References
RefSeq
NP_058762.1
Ensembl
ENSRNOG00000011946
,
ENSRNOT00000016088
,
ENSRNOP00000016088
PRO
P63090
RGD
3444
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