ALK dimerization

Stable Identifier
R-RNO-201531
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
General
SVG |   | PPTX  | SBGN
ALK dimerization

Studies with inducible dimerization constructs of rat ALK show that dimerization is required to activate downstream signaling cascades including PI3K/AKT, PLC gamma, MAP kinase and STAT pathways, among others (Gouzi et al, 2005; Stoica et al, 2001; Stoica et al, 2002).

Literature References
PubMed ID Title Journal Year
16317043 Role of the subcellular localization of ALK tyrosine kinase domain in neuronal differentiation of PC12 cells

Vigny, M, Brunet-de Carvalho, N, Moog-Lutz, C, Gouzi, JY

J Cell Sci 2005
11278720 Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin

Wellstein, A, Caughey, DJ, Kuo, AH, Karavanov, A, Sunitha, I, Malerczyk, C, Aigner, A, Riegel, AT, Souttou, B, Stoica, GE, Wen, D

J Biol Chem 2001
12122009 Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types

Wellstein, A, Kuo, AH, Stoica, GE, Riegel, AT, Bowden, ET, Sale, EB, Powers, C

J. Biol. Chem. 2002
Participants
Orthologous Events
Authored
Reviewed
Created
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