Reactome | ALK dimerization

ALK dimerization

Stable Identifier

R-RNO-201531

Type

Reaction [binding]

Species

Rattus norvegicus

Compartment

plasma membrane

ReviewStatus

5/5

General

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SVG | | PPTX | SBGN

Studies with inducible dimerization constructs of rat ALK show that dimerization is required to activate downstream signaling cascades including PI3K/AKT, PLC gamma, MAP kinase and STAT pathways, among others (Gouzi et al, 2005; Stoica et al, 2001; Stoica et al, 2002).

Literature References

PubMed ID	Title	Journal	Year
12122009	Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types Wellstein, A, Kuo, AH, Stoica, GE, Riegel, AT, Bowden, ET, Sale, EB, Powers, C	J. Biol. Chem.	2002
16317043	Role of the subcellular localization of ALK tyrosine kinase domain in neuronal differentiation of PC12 cells Vigny, M, Brunet-de Carvalho, N, Moog-Lutz, C, Gouzi, JY	J Cell Sci	2005
11278720	Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin Wellstein, A, Caughey, DJ, Kuo, AH, Karavanov, A, Sunitha, I, Malerczyk, C, Aigner, A, Riegel, AT, Souttou, B, Stoica, GE, Wen, D	J Biol Chem	2001