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PRKN [cytosol]
Stable Identifier
R-RNO-201579
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
Q9JK66
Locations in the PathwayBrowser
Expand all
Autophagy (Rattus norvegicus)
Macroautophagy (Rattus norvegicus)
Selective autophagy (Rattus norvegicus)
Aggrephagy (Rattus norvegicus)
Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Rattus norvegicus)
Misfolded proteins:PRKN:UBE2N:UBE2V1:Ub [cytosol] (Rattus norvegicus)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Rattus norvegicus)
PRKN [cytosol] (Rattus norvegicus)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Rattus norvegicus)
PRKN [cytosol] (Rattus norvegicus)
Parkin transfers Ub to misfolded proteins (Rattus norvegicus)
Misfolded proteins:PRKN:UBE2N:UBE2V1:Ub [cytosol] (Rattus norvegicus)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Rattus norvegicus)
PRKN [cytosol] (Rattus norvegicus)
Ub:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Rattus norvegicus)
UBE2N:UBE2V1:PRKN [cytosol] (Rattus norvegicus)
PRKN [cytosol] (Rattus norvegicus)
Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Rattus norvegicus)
PolyUb:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Rattus norvegicus)
UBE2N:UBE2V1:PRKN [cytosol] (Rattus norvegicus)
PRKN [cytosol] (Rattus norvegicus)
Ub:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Rattus norvegicus)
UBE2N:UBE2V1:PRKN [cytosol] (Rattus norvegicus)
PRKN [cytosol] (Rattus norvegicus)
Mitophagy (Rattus norvegicus)
PINK1-PRKN Mediated Mitophagy (Rattus norvegicus)
PINK1 phosphorylates PRKN at S65 (Rattus norvegicus)
PRKN:Ub-MOM proteins [mitochondrial outer membrane] (Rattus norvegicus)
PRKN [cytosol] (Rattus norvegicus)
PRKN binds p-S-Ub:MOM proteins (Rattus norvegicus)
PRKN [cytosol] (Rattus norvegicus)
PRKN:Ub-MOM proteins [mitochondrial outer membrane] (Rattus norvegicus)
PRKN [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Class I MHC mediated antigen processing & presentation (Rattus norvegicus)
Antigen processing: Ubiquitination & Proteasome degradation (Rattus norvegicus)
Interaction of E3 with substrate and E2-Ub complex (Rattus norvegicus)
Ag-substrate:E3:E2:Ub [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
PRKN [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
PRKN [cytosol] (Rattus norvegicus)
Polyubiquitination of substrate (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
PRKN [cytosol] (Rattus norvegicus)
E3:K48-polyubiquitinated substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
PRKN [cytosol] (Rattus norvegicus)
E3:Ub:substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
PRKN [cytosol] (Rattus norvegicus)
Release of E3 from polyubiquitinated substrate (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
PRKN [cytosol] (Rattus norvegicus)
E3:K48-polyubiquitinated substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
PRKN [cytosol] (Rattus norvegicus)
Transfer of Ub from E2 to substrate and release of E2 (Rattus norvegicus)
Ag-substrate:E3:E2:Ub [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
PRKN [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
PRKN [cytosol] (Rattus norvegicus)
E3:Ub:substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
PRKN [cytosol] (Rattus norvegicus)
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
Deubiquitination (Rattus norvegicus)
Josephin domain DUBs (Rattus norvegicus)
ATXN3 deubiquitinates polyUb-PARK2 (Rattus norvegicus)
ATXN3:PARK2 [cytosol] (Rattus norvegicus)
PRKN [cytosol] (Rattus norvegicus)
PARK2 autoubiquitinates (Rattus norvegicus)
PRKN [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q9JK66
Reference Genes
BioGPS Gene:56816
ENSEMBL:ENSRNOG00000055547
KEGG:rno:56816
Monarch:56816
NCBI Gene:56816
UCSC:Q9JK66
Reference Transcript
RefSeq:NM_020093.1
Other Identifiers
10718010
1369138_a_at
17628529
5635915
5648900
56816
5772550
5780371
5781794
5829566
6066905
6205607
6221092
6252261
6364803
6375875
6395357
6405218
6502575
6641527
6647631
6692662
6699154
A_43_P12065
A_44_P201130
A_64_P046677
GO:0000122
GO:0000151
GO:0000209
GO:0000423
GO:0001664
GO:0001933
GO:0001963
GO:0001964
GO:0003714
GO:0003779
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005783
GO:0005794
GO:0005829
GO:0006351
GO:0006355
GO:0006511
GO:0006513
GO:0006914
GO:0007005
GO:0007010
GO:0007612
GO:0007626
GO:0008013
GO:0008092
GO:0008270
GO:0008344
GO:0010498
GO:0010506
GO:0010628
GO:0010629
GO:0010636
GO:0010821
GO:0010994
GO:0012501
GO:0015631
GO:0016192
GO:0016235
GO:0016567
GO:0016607
GO:0016740
GO:0019538
GO:0019899
GO:0019900
GO:0019901
GO:0023052
GO:0030154
GO:0030163
GO:0030165
GO:0030544
GO:0031072
GO:0031396
GO:0031410
GO:0031624
GO:0031625
GO:0031647
GO:0031648
GO:0032232
GO:0032436
GO:0032991
GO:0034976
GO:0035249
GO:0036211
GO:0042053
GO:0042415
GO:0042417
GO:0042802
GO:0042826
GO:0043005
GO:0043123
GO:0043130
GO:0043161
GO:0043226
GO:0043274
GO:0043524
GO:0044828
GO:0044877
GO:0045944
GO:0046676
GO:0046928
GO:0048471
GO:0048856
GO:0050804
GO:0050821
GO:0050877
GO:0051087
GO:0051582
GO:0051583
GO:0051865
GO:0051881
GO:0061024
GO:0061630
GO:0061734
GO:0065003
GO:0070534
GO:0070585
GO:0070842
GO:0070936
GO:0070979
GO:0085020
GO:0090090
GO:0090201
GO:0097237
GO:0097602
GO:0098691
GO:0098779
GO:0099073
GO:0099074
GO:0140096
GO:0140110
GO:0140251
GO:1900242
GO:1900407
GO:1901526
GO:1901800
GO:1902236
GO:1902254
GO:1902530
GO:1903265
GO:1903377
GO:1903382
GO:1903542
GO:1903861
GO:1904049
GO:1905366
GO:1905477
GO:1990381
GO:1990444
GO:1990452
GO:2000377
GO:2000378
PH_rn_0022905
Participates
as a component of
ATXN3:PARK2 [cytosol] (Rattus norvegicus)
PRKN:Ub-MOM proteins [mitochondrial outer membrane] (Rattus norvegicus)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Rattus norvegicus)
UBE2N:UBE2V1:PRKN [cytosol] (Rattus norvegicus)
as an input of
PARK2 autoubiquitinates (Rattus norvegicus)
PRKN binds p-S-Ub:MOM proteins (Rattus norvegicus)
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
Other forms of this molecule
polyUb-PARK2 [cytosol]
phospho-p-S9-PRKN [cytosol]
phospho-p-S65-PRKN [cytosol]
Inferred From
PRKN [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_064478.1
ENSEMBL
ENSRNOP00000088932
,
ENSRNOP00000077507
,
ENSRNOT00000107769
,
ENSRNOT00000096213
PRO
Q9JK66
RGD
61797
PDB
4K95
,
4K7D
,
4ZYN
,
7US1
,
2KNB
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q62915 Cask
2
Cask [cytosol]
(R-RNO-451401)
CASK [cytosol]
(R-RNO-373631)
0.556
3
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