Reactome | Wipf1 [cytosol]

Wipf1 [cytosol]

Stable Identifier

R-RNO-201874

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

WIPF1, Q6IN36

Locations in the PathwayBrowser

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Immune System (Rattus norvegicus)

- Innate Immune System (Rattus norvegicus)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Rattus norvegicus)
    - Regulation of actin dynamics for phagocytic cup formation (Rattus norvegicus)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Rattus norvegicus)
        
        Mother filament:branching complex [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
        
        WIP family proteins [cytosol] (Rattus norvegicus)
        
        Wipf1 [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
        
        WIP family proteins [cytosol] (Rattus norvegicus)
        
        Wipf1 [cytosol] (Rattus norvegicus)
      - Detachment of WASP/WAVE (Rattus norvegicus)
        
        Mother filament:branching complex [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
        
        WIP family proteins [cytosol] (Rattus norvegicus)
        
        Wipf1 [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
        
        WIP family proteins [cytosol] (Rattus norvegicus)
        
        Wipf1 [cytosol] (Rattus norvegicus)
      - Src phosphorylate WASP,N-WASP (Rattus norvegicus)
        
        CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
        
        WIP family proteins [cytosol] (Rattus norvegicus)
        
        Wipf1 [cytosol] (Rattus norvegicus)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
        
        WIP family proteins [cytosol] (Rattus norvegicus)
        
        Wipf1 [cytosol] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Rattus norvegicus)
  - Signaling by Rho GTPases (Rattus norvegicus)
    - RHO GTPase Effectors (Rattus norvegicus)
      - RHO GTPases Activate WASPs and WAVEs (Rattus norvegicus)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Rattus norvegicus)
        
        Mother filament:branching complex [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
        
        WIP family proteins [cytosol] (Rattus norvegicus)
        
        Wipf1 [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
        
        WIP family proteins [cytosol] (Rattus norvegicus)
        
        Wipf1 [cytosol] (Rattus norvegicus)
        
        Detachment of WASP/WAVE (Rattus norvegicus)
        
        Mother filament:branching complex [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
        
        WIP family proteins [cytosol] (Rattus norvegicus)
        
        Wipf1 [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
        
        WIP family proteins [cytosol] (Rattus norvegicus)
        
        Wipf1 [cytosol] (Rattus norvegicus)
        
        Src phosphorylate WASP,N-WASP (Rattus norvegicus)
        
        CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
        
        WIP family proteins [cytosol] (Rattus norvegicus)
        
        Wipf1 [cytosol] (Rattus norvegicus)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
        
        WIP family proteins [cytosol] (Rattus norvegicus)
        
        Wipf1 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q6IN36

Gene Names

Wipf1

Reference Genes

BioGPS Gene:117538 Wipf1

ENSEMBL:ENSRNOG00000018406

ENSEMBL:ENSRNOG00055023131

ENSEMBL:ENSRNOG00060015184

ENSEMBL:ENSRNOG00065017440

KEGG Gene (Rattus norvegicus):117538 Wipf1

Monarch:117538 Wipf1

NCBI Gene:117538 Wipf1

UCSC:Q6IN36 Wipf1

Reference Transcript

RefSeq:NM_057192.2 Wipf1

Participates

as a member of

WIP family proteins [cytosol] (Rattus norvegicus)

Inferred From

WIPF1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_476540.2

PRO

Q6IN36

RGD

620887

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31016 Dlg4	3	Dlg4 [cytosol] (R-RNO-6794248) Dlg4 [endocytic vesicle membrane] (R-RNO-416847) Dlg4 [plasma membrane] (R-RNO-9612601)	0.556	5
UniProt:P60711 Actb	5	Beta actin_Rat [cytosol] (R-RNO-443585) Actb [nucleoplasm] (R-RNO-3321990) Actb [cytosol] (R-RNO-201861) Actb [lysosomal membrane] (R-RNO-196160) Actb [plasma membrane] (R-RNO-196016)	0.463	2

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