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PLCG1 [cytosol]
Stable Identifier
R-RNO-202320
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
P10686
Locations in the PathwayBrowser for interactor UniProt:Q9ES52
Expand all
Developmental Biology (Rattus norvegicus)
Nervous system development (Rattus norvegicus)
Axon guidance (Rattus norvegicus)
RET signaling (Rattus norvegicus)
2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Rattus norvegicus)
PLCG1 [cytosol] (Rattus norvegicus)
Hemostasis (Rattus norvegicus)
Cell surface interactions at the vascular wall (Rattus norvegicus)
PECAM1 interactions (Rattus norvegicus)
Interaction of PECAM-1 and PLC gamma1 (Rattus norvegicus)
PLCG1 [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
TCR signaling (Rattus norvegicus)
Generation of second messenger molecules (Rattus norvegicus)
Recruitment of PLC-gamma1 to LAT (Rattus norvegicus)
PLCG1 [cytosol] (Rattus norvegicus)
Recruitment of PLC-gamma1 to SLP-76 (Rattus norvegicus)
PLCG1 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by EGFR (Rattus norvegicus)
EGFR interacts with phospholipase C-gamma (Rattus norvegicus)
Phospholipase C-gamma1 binds to the activated EGF receptor (Rattus norvegicus)
PLCG1 [cytosol] (Rattus norvegicus)
Signaling by VEGF (Rattus norvegicus)
VEGFA-VEGFR2 Pathway (Rattus norvegicus)
VEGFR2 mediated cell proliferation (Rattus norvegicus)
p-6Y-VEGFR2 binds PLCG1 (Rattus norvegicus)
PLCG1 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P10686 Plcg1
Gene Names
Plcg1
Chain
initiator methionine:, chain:2-1290
Reference Genes
BioGPS Gene:25738 Plcg1
KEGG Gene (Rattus norvegicus):25738 Plcg1
Monarch:25738 Plcg1
NCBI Gene:25738 Plcg1
UCSC:P10686 Plcg1
Reference Transcript
RefSeq:NM_013187.1 Plcg1
Participates
as an input of
2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Rattus norvegicus)
Interaction of PECAM-1 and PLC gamma1 (Rattus norvegicus)
Recruitment of PLC-gamma1 to SLP-76 (Rattus norvegicus)
Recruitment of PLC-gamma1 to LAT (Rattus norvegicus)
Phospholipase C-gamma1 binds to the activated EGF receptor (Rattus norvegicus)
p-6Y-VEGFR2 binds PLCG1 (Rattus norvegicus)
as a component of
2x p-5Y-RET:GDNF:GFRA complexes:PLCG1 [plasma membrane] (Rattus norvegicus)
PECAM-1:PLC gamma1 complex [plasma membrane] (Rattus norvegicus)
PLCG1:p-3Y-SLP-76:Gads:LAT [plasma membrane] (Rattus norvegicus)
PLCG1:p-5Y-LAT [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PLCG1 [plasma membrane] (Rattus norvegicus)
as a member of
ISG15 targets [cytosol] (Rattus norvegicus)
PLC gamma1,2 [cytosol] (Rattus norvegicus)
Other forms of this molecule
p-4Y-Plcg1 [plasma membrane]
phospho-p-Y771,Y783-PLCG1 [plasma membrane]
phospho-p-Y771,Y783,Y1254-PLCG1 [cytosol]
p-Plcg1 [plasma membrane]
Plcg1 [plasma membrane]
PLCG1 [plasma membrane]
phospho-p-4Y-PLCG1 [plasma membrane]
Inferred From
PLCG1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_037319.1
ZINC target
P10686
PRO
P10686
RGD
3347
PDB
6PBC
,
3GQI
,
1YWO
,
2FJL
,
1YWP
,
4K44
,
4K45
,
1Y0M
,
5EG3
,
7Z3J
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P11362 FGFR1
9
FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853241)
FGFR1 K656E [plasma membrane]
(R-HSA-1614373)
FGFR1 N546K [plasma membrane]
(R-HSA-1614377)
FGFR1 R576W [plasma membrane]
(R-HSA-2011844)
p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853142)
p-8Y-FGFR1 K656E [plasma membrane]
(R-HSA-2023356)
p-8Y-FGFR1 N546K [plasma membrane]
(R-HSA-2023358)
p-8Y- FGFR1 R576W [plasma membrane]
(R-HSA-2023361)
FGFR1 [plasma membrane]
(R-HSA-9756433)
0.611
4
UniProt:Q63537
1
Syn2 [clathrin-sculpted monoamine transport vesicle membrane]
(R-RNO-380579)
0.602
5
UniProt:Q8CGU4 Agap2
1
PIKE-L_RAT [cytosol]
(R-RNO-622356)
0.602
4
UniProt:Q08881 ITK
3
p-Y180,Y512-ITK [cytosol]
(R-HSA-2685616)
p-Y512-ITK [cytosol]
(R-HSA-422519)
ITK [cytosol]
(R-HSA-202319)
0.59
2
UniProt:P18031 PTPN1
2
PTPN1 [cytosol]
(R-HSA-210625)
PTPN1 [endosome membrane]
(R-HSA-9815895)
0.556
4
UniProt:Q9ES52 Inpp5d
3
p-Y-Inpp5d [cytosol]
(R-MMU-9680732)
Inpp5d [cytosol]
(R-MMU-9680650)
Inpp5d [cytosol]
(R-MMU-197940)
0.524
3
UniProt:Q13507 TRPC3
1
TRPC3(1-848) [plasma membrane]
(R-HSA-426172)
0.508
2
UniProt:Q62120 Jak2
11
phospho-p-Y1007,Y1008-JAK2 [cytosol]
(R-MMU-9005327)
p-Jak2 [cytosol]
(R-MMU-8950633)
phospho-p-JAK2 [cytosol]
(R-MMU-210621)
phospho-p-Y813-JAK2 [cytosol]
(R-MMU-997248)
JAK2 [endosome lumen]
(R-MMU-2002372)
JAK2 [cytosol]
(R-MMU-210620)
phospho-p-Y1007-JAK2 [cytosol]
(R-MMU-873799)
Jak2 [cytosol]
(R-MMU-205743)
phospho-p-12Y-JAK2 [cytosol]
(R-MMU-2586516)
p-Y1007-Jak2 [cytosol]
(R-MMU-997296)
p-12Y-Jak2 [cytosol]
(R-MMU-2586515)
0.463
3
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