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About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
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Developer's Zone
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FAQ
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Citing us
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CSK [cytosol]
Stable Identifier
R-RNO-203776
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
P32577
Locations in the PathwayBrowser
Expand all
Hemostasis (Rattus norvegicus)
Platelet activation, signaling and aggregation (Rattus norvegicus)
Platelet Aggregation (Plug Formation) (Rattus norvegicus)
Integrin signaling (Rattus norvegicus)
Activated integrin alphaIIb beta3 binds SHC1 (Rattus norvegicus)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
Clustering of Integrin alphaIIb beta3 complexes (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
Integrin alphaIIb beta3 activation (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
Interaction of integrin alphaIIb beta3 with Fibrinogen (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
Release of CSK from SRC (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Rattus norvegicus)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
SHC1 dissociates from integrin alphaIIb beta3 (Rattus norvegicus)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Costimulation by the CD28 family (Rattus norvegicus)
PD-1 signaling (Rattus norvegicus)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Rattus norvegicus)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Rattus norvegicus)
p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Rattus norvegicus)
LCK, CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
Interaction of SHP-1 or SHP-2 with phospho PD-1 (Rattus norvegicus)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Rattus norvegicus)
p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Rattus norvegicus)
LCK, CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Rattus norvegicus)
LCK, CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
Phosphorylation of PD-1 (Rattus norvegicus)
LCK, CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Rattus norvegicus)
LCK, CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
TCR signaling (Rattus norvegicus)
Phosphorylation of CD3 and TCR zeta chains (Rattus norvegicus)
Inactivation of Lck by Csk (Rattus norvegicus)
Csk:p-PAG [plasma membrane] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
Interaction of Csk with PAG (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
Csk:p-PAG [plasma membrane] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
PTPN22 dissociates from CSK (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
PTPN22:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Integrin signaling (Rattus norvegicus)
Activated integrin alphaIIb beta3 binds SHC1 (Rattus norvegicus)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
Clustering of Integrin alphaIIb beta3 complexes (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
Integrin alphaIIb beta3 activation (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
Interaction of integrin alphaIIb beta3 with Fibrinogen (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
Release of CSK from SRC (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Rattus norvegicus)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
SHC1 dissociates from integrin alphaIIb beta3 (Rattus norvegicus)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
MAPK family signaling cascades (Rattus norvegicus)
MAPK1/MAPK3 signaling (Rattus norvegicus)
RAF/MAP kinase cascade (Rattus norvegicus)
MAP2K and MAPK activation (Rattus norvegicus)
Dissociation of RAS:RAF complex (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
Dual mechanism MAPK inhibitors bind MAPKs (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
MAP2Ks and MAPKs bind to the activated RAF complex (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
MAP2Ks phosphorylate MAPKs (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
RAF phosphorylates MAP2K dimer (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Rattus norvegicus)
Signaling by Rho GTPases (Rattus norvegicus)
RHO GTPase cycle (Rattus norvegicus)
RHOH GTPase cycle (Rattus norvegicus)
RHOH binds effectors at the plasma membrane (Rattus norvegicus)
RHOH effectors [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
RHOH:GTP:RHOH effectors [plasma membrane] (Rattus norvegicus)
RHOH effectors [cytosol] (Rattus norvegicus)
CSK [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P32577
Reference Genes
BioGPS Gene:315707
ENSEMBL:ENSRNOG00000019374
ENSEMBL:ENSRNOG00000019374.7
ENSEMBL:ENSRNOG00055029546
ENSEMBL:ENSRNOG00060021015
ENSEMBL:ENSRNOG00065017300
KEGG Gene (Rattus norvegicus):315707
Monarch:315707
NCBI Gene:315707
UCSC:P32577
Reference Transcript
RefSeq:XM_006243164.3
RefSeq:NM_001030039.1
RefSeq:XM_006243163.1
Other Identifiers
10917795
1371592_at
17852970
315707
5619806
5682372
5895197
5962562
6078735
6089208
6241354
6321029
6366910
6593999
6601971
6606196
6737745
A_42_P540933
A_44_P308932
GO:0003824
GO:0004672
GO:0004713
GO:0005515
GO:0005524
GO:0005886
GO:0005911
GO:0006468
GO:0008285
GO:0016192
GO:0016740
GO:0034236
GO:0036211
GO:0042802
GO:0042997
GO:0072659
GO:0140096
ILMN_1370626
X58631cds_at
rc_AI177363_s_at
rc_AI178605_at
Participates
as a member of
RHOH effectors [cytosol] (Rattus norvegicus)
LCK, CSK [cytosol] (Rattus norvegicus)
as an output of
Release of CSK from SRC (Rattus norvegicus)
PTPN22 dissociates from CSK (Rattus norvegicus)
as a component of
PTPN22:CSK [cytosol] (Rattus norvegicus)
Csk:p-PAG [plasma membrane] (Rattus norvegicus)
p-Y530-SRC:CSK [cytosol] (Rattus norvegicus)
as an input of
Interaction of Csk with PAG (Rattus norvegicus)
Other forms of this molecule
CSK [plasma membrane]
Inferred From
CSK [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_006243225.1
,
NP_001025210.1
,
XP_006243226.1
ZINC target
P32577
Ensembl
ENSRNOP00000026358
,
ENSRNOT00000026358
,
ENSRNOG00000019374
PRO
P32577
ZINC - Predictions - Purchasable
CSK_RAT
RGD
1308800
PDB
1K9A
,
2RSY
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q61152
1
PTPN18 [cytosol]
(R-MMU-8864101)
0.593
5
UniProt:P06239 LCK
4
p-Y394-LCK [plasma membrane]
(R-HSA-8857940)
p-Y505-LCK [plasma membrane]
(R-HSA-202159)
p-Y394-LCK [cytosol]
(R-HSA-202308)
LCK [cytosol]
(R-HSA-167609)
0.482
2
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