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Nck2 [cytosol]
Stable Identifier
R-RNO-204885
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
NCK2, D4A3M8
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Rattus norvegicus)
Nephrin family interactions (Rattus norvegicus)
Nephrin binds NCK (Rattus norvegicus)
NCK1,NCK2 [cytosol] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
NEPH1:p-Nephrin:Fyn:NCK [plasma membrane] (Rattus norvegicus)
NCK1,NCK2 [cytosol] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
Developmental Biology (Rattus norvegicus)
Nervous system development (Rattus norvegicus)
Axon guidance (Rattus norvegicus)
EPH-Ephrin signaling (Rattus norvegicus)
Ephrin signaling (Rattus norvegicus)
EFNB:GRB4 binds GIT1 (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
GIT1 binds bPIX (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
PAK binds RAC and bPIX (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
PAKs autophosphorylate (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
PAKs phosphorylate MLC (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
bPIX exchanges GTP for GDP on RAC, activating it (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
p-EFNB binds GRB4 (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by PDGF (Rattus norvegicus)
Downstream signal transduction (Rattus norvegicus)
Nck binds to the active PDGF receptor (Rattus norvegicus)
NCK1,NCK2 [cytosol] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
PDGF:Phospho-PDGFR receptor dimer:Nck [plasma membrane] (Rattus norvegicus)
NCK1,NCK2 [cytosol] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
Signaling by VEGF (Rattus norvegicus)
VEGFA-VEGFR2 Pathway (Rattus norvegicus)
CDC42:GTP binds PAK2 (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Rattus norvegicus)
NCK1,NCK2 [cytosol] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Rattus norvegicus)
NCK1,NCK2 [cytosol] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
FYN autophosphorylates (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane] (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Rattus norvegicus)
NCK1,NCK2 [cytosol] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN [plasma membrane] (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Rattus norvegicus)
NCK1,NCK2 [cytosol] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
FYN phosphorylates PAK2 (Rattus norvegicus)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane] (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Rattus norvegicus)
NCK1,NCK2 [cytosol] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Rattus norvegicus)
NCK1,NCK2 [cytosol] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
PAK2 autophorylates (Rattus norvegicus)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Rattus norvegicus)
NCK1,NCK2 [cytosol] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane] (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Rattus norvegicus)
NCK1,NCK2 [cytosol] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
PAK2 binds NCK (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Rattus norvegicus)
NCK1,NCK2 [cytosol] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Rattus norvegicus)
NCK1,NCK2 [cytosol] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
p-6Y-VEGFR2 binds FYN (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Rattus norvegicus)
NCK1,NCK2 [cytosol] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane] (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Rattus norvegicus)
NCK1,NCK2 [cytosol] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
p-6Y-VEGFR2 binds NCK (Rattus norvegicus)
NCK1,NCK2 [cytosol] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Rattus norvegicus)
NCK1,NCK2 [cytosol] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
p-Y420-FYN is phosphorylated on S21 (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Rattus norvegicus)
NCK1,NCK2 [cytosol] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN [plasma membrane] (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Rattus norvegicus)
NCK1,NCK2 [cytosol] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
p38 MAPK activation by VEGFR (Rattus norvegicus)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Rattus norvegicus)
NCK1,NCK2 [cytosol] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Rattus norvegicus)
Signaling by Rho GTPases (Rattus norvegicus)
RHO GTPase cycle (Rattus norvegicus)
RHOU GTPase cycle (Rattus norvegicus)
RHOU binds effectors at the plasma membrane (Rattus norvegicus)
RHOU effectors [cytosol] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
RHOU:GTP:RHOU effectors [plasma membrane] (Rattus norvegicus)
RHOU effectors [cytosol] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
RHOV GTPase cycle (Rattus norvegicus)
RHOV binds effectors at the plasma membrane (Rattus norvegicus)
RHOV effectors [cytosol] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
RHOV:GTP:RHOV effectors [plasma membrane] (Rattus norvegicus)
RHOV effectors [cytosol] (Rattus norvegicus)
Nck2 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:D4A3M8
Gene Names
Nck2
Reference Genes
BioGPS Gene:316369 Nck2
ENSEMBL:ENSRNOG00000017155
KEGG Gene (Rattus norvegicus):316369 Nck2
Monarch:316369 Nck2
NCBI Gene:316369 Nck2
UCSC:D4A3M8 Nck2
Reference Transcript
RefSeq:XM_008767035.2 Nck2
RefSeq:NM_001108216.1 Nck2
RefSeq:XM_006244825.3 Nck2
Other Identifiers
10922956
1398441_at
17858841
316369
5682453
5695277
5865959
6087787
6404617
6434469
A_42_P698520
A_44_P207215
GE1149174
GO:0001771
GO:0001784
GO:0002376
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005783
GO:0005829
GO:0006412
GO:0006417
GO:0006464
GO:0006950
GO:0007010
GO:0007015
GO:0007155
GO:0007165
GO:0008150
GO:0008219
GO:0008283
GO:0009058
GO:0012506
GO:0014069
GO:0016301
GO:0016310
GO:0016477
GO:0019899
GO:0022607
GO:0030032
GO:0030154
GO:0030674
GO:0030838
GO:0030971
GO:0033137
GO:0034641
GO:0035591
GO:0036493
GO:0040011
GO:0042102
GO:0043226
GO:0044877
GO:0045202
GO:0045944
GO:0048013
GO:0048856
GO:0048870
GO:0060996
GO:0065003
GO:0097110
GO:1902237
GO:1903898
GO:1903912
GO:1990441
ILMN_1359798
PH_rn_0010944
rc_AA957410_at
Participates
as a candidate of
RHOV effectors [cytosol] (Rattus norvegicus)
as a member of
RHOU effectors [cytosol] (Rattus norvegicus)
NCK1,NCK2 [cytosol] (Rattus norvegicus)
as an input of
p-EFNB binds GRB4 (Rattus norvegicus)
as a component of
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Rattus norvegicus)
Inferred From
NCK2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_006244887.1
,
XP_008765257.1
,
NP_001101686.1
Ensembl
ENSRNOP00000023029
,
ENSRNOT00000023029
,
ENSRNOG00000017155
RGD
1305965
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