Reactome | Hdac1 [nucleoplasm]

Hdac1 [nucleoplasm]

Stable Identifier

R-RNO-205009

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

nucleoplasm

Synonyms

Histone deacetylase 1, HDAC1_RAT

Locations in the PathwayBrowser

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Cell-Cell communication (Rattus norvegicus)

- Cell junction organization (Rattus norvegicus)
  - Cell-cell junction organization (Rattus norvegicus)
    - Adherens junctions interactions (Rattus norvegicus)
      - Regulation of Homotypic Cell-Cell Adhesion (Rattus norvegicus)
        
        Regulation of Expression and Function of Type I Classical Cadherins (Rattus norvegicus)
        
        Regulation of CDH1 Expression and Function (Rattus norvegicus)
        
        Regulation of CDH1 Gene Transcription (Rattus norvegicus)
        
        Negative Regulation of CDH1 Gene Transcription (Rattus norvegicus)
        
        ZEB1 recruits TLE1 and HDAC1/2 to CDH1 gene promoter (Rattus norvegicus)
        
        HDAC1,(HDAC2) dimers [nucleoplasm] (Rattus norvegicus)
        
        HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
        
        Hdac1 [nucleoplasm] (Rattus norvegicus)
        
        Hdac1 homodimer [nucleoplasm] (Rattus norvegicus)
        
        Hdac1 [nucleoplasm] (Rattus norvegicus)
        
        HDAC1,(HDAC2):TLE1:ZEB1:CDH1 gene [nucleoplasm] (Rattus norvegicus)
        
        HDAC1,(HDAC2) dimers [nucleoplasm] (Rattus norvegicus)
        
        HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
        
        Hdac1 [nucleoplasm] (Rattus norvegicus)
        
        Hdac1 homodimer [nucleoplasm] (Rattus norvegicus)
        
        Hdac1 [nucleoplasm] (Rattus norvegicus)

Chromatin organization (Rattus norvegicus)

- Chromatin modifying enzymes (Rattus norvegicus)
  - HDACs deacetylate histones (Rattus norvegicus)
    - HDAC1:2-containing complex binds HDAC2 Inhibitors (Rattus norvegicus)
      - HDAC1:2-containing complex [nucleoplasm] (Rattus norvegicus)
        
        BHC complex [nucleoplasm] (Rattus norvegicus)
        
        HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
        
        Hdac1 [nucleoplasm] (Rattus norvegicus)
        
        CoREST complex [nucleoplasm] (Rattus norvegicus)
        
        HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
        
        Hdac1 [nucleoplasm] (Rattus norvegicus)
        
        NuRD complex [nucleoplasm] (Rattus norvegicus)
        
        HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
        
        Hdac1 [nucleoplasm] (Rattus norvegicus)
        
        Sin3A complex [nucleoplasm] (Rattus norvegicus)
        
        Sin3a core complex [nucleoplasm] (Rattus norvegicus)
        
        HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
        
        Hdac1 [nucleoplasm] (Rattus norvegicus)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Rattus norvegicus)
        
        HDAC1:2-containing complex [nucleoplasm] (Rattus norvegicus)
        
        BHC complex [nucleoplasm] (Rattus norvegicus)
        
        HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
        
        Hdac1 [nucleoplasm] (Rattus norvegicus)
        
        CoREST complex [nucleoplasm] (Rattus norvegicus)
        
        HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
        
        Hdac1 [nucleoplasm] (Rattus norvegicus)
        
        NuRD complex [nucleoplasm] (Rattus norvegicus)
        
        HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
        
        Hdac1 [nucleoplasm] (Rattus norvegicus)
        
        Sin3A complex [nucleoplasm] (Rattus norvegicus)
        
        Sin3a core complex [nucleoplasm] (Rattus norvegicus)
        
        HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
        
        Hdac1 [nucleoplasm] (Rattus norvegicus)
    - HDAC1:2-containing complex deacetylate histones (Rattus norvegicus)
      - HDAC1:2-containing complex [nucleoplasm] (Rattus norvegicus)
        
        BHC complex [nucleoplasm] (Rattus norvegicus)
        
        HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
        
        Hdac1 [nucleoplasm] (Rattus norvegicus)
        
        CoREST complex [nucleoplasm] (Rattus norvegicus)
        
        HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
        
        Hdac1 [nucleoplasm] (Rattus norvegicus)
        
        NuRD complex [nucleoplasm] (Rattus norvegicus)
        
        HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
        
        Hdac1 [nucleoplasm] (Rattus norvegicus)
        
        Sin3A complex [nucleoplasm] (Rattus norvegicus)
        
        Sin3a core complex [nucleoplasm] (Rattus norvegicus)
        
        HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
        
        Hdac1 [nucleoplasm] (Rattus norvegicus)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Rattus norvegicus)
        
        HDAC1:2-containing complex [nucleoplasm] (Rattus norvegicus)
        
        BHC complex [nucleoplasm] (Rattus norvegicus)
        
        HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
        
        Hdac1 [nucleoplasm] (Rattus norvegicus)
        
        CoREST complex [nucleoplasm] (Rattus norvegicus)
        
        HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
        
        Hdac1 [nucleoplasm] (Rattus norvegicus)
        
        NuRD complex [nucleoplasm] (Rattus norvegicus)
        
        HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
        
        Hdac1 [nucleoplasm] (Rattus norvegicus)
        
        Sin3A complex [nucleoplasm] (Rattus norvegicus)
        
        Sin3a core complex [nucleoplasm] (Rattus norvegicus)
        
        HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
        
        Hdac1 [nucleoplasm] (Rattus norvegicus)

Hemostasis (Rattus norvegicus)

- Factors involved in megakaryocyte development and platelet production (Rattus norvegicus)
  - REST recruits the BHC complex (Rattus norvegicus)
    - BHC complex [nucleoplasm] (Rattus norvegicus)
      - HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
        
        Hdac1 [nucleoplasm] (Rattus norvegicus)
    - BHC complex:REST:REST DNA binding sites [nucleoplasm] (Rattus norvegicus)
      - BHC complex [nucleoplasm] (Rattus norvegicus)
        
        HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
        
        Hdac1 [nucleoplasm] (Rattus norvegicus)

Metabolism of proteins (Rattus norvegicus)

- Post-translational protein modification (Rattus norvegicus)
  - SUMOylation (Rattus norvegicus)
    - SUMO E3 ligases SUMOylate target proteins (Rattus norvegicus)
      - SUMOylation of chromatin organization proteins (Rattus norvegicus)
        
        SUMOylation of HDAC1 with SUMO1 (Rattus norvegicus)
        
        Hdac1 [nucleoplasm] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q4QQW4 Hdac1

Gene Names

Hdac1

Chain

chain:1-482

Reference Genes

BioGPS Gene:297893 Hdac1

KEGG:rno:297893 Hdac1

Monarch:297893 Hdac1

NCBI Gene:297893 Hdac1

UCSC:Q4QQW4 Hdac1

Reference Transcript

RefSeq:NM_001025409.1 Hdac1

Other Identifiers

10880012

10929261

1388761_at

1396820_at

17810818

297893

5622685

5631536

5731857

5818804

5831681

5899058

5916883

5947251

5960570

5998451

6015995

6049603

6142089

6190798

6244524

6286039

6301005

6327035

6348371

6349177

6503058

A_64_P118296

A_64_P122452

GE17746

GO:0000785

GO:0003682

GO:0003824

GO:0004407

GO:0005634

GO:0005737

GO:0006325

GO:0008284

GO:0010648

GO:0016787

GO:0019213

GO:0023057

GO:0032991

GO:0043066

GO:0046872

GO:0048511

GO:0048714

GO:0140096

GO:0140297

PH_rn_0015141

rc_AA818418_at

Participates

as an input of

as a component of

as a member of

as an output of

Other forms of this molecule

Hdac1 [nucleoplasm]

Inferred From

HDAC1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001020580.1

ENSEMBL

ENSRNOP00000012854, ENSRNOG00000009568, ENSRNOT00000012854

ZINC - Substances

HDAC1_RAT

ZINC target

Q4QQW4

PRO

Q4QQW4

RGD

1309799

ZINC - Predictions - Purchasable

HDAC1_RAT

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