Prdm4 inhibits cyclin E transcription

Stable Identifier
R-RNO-205010
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Prdm4 inhibits cyclin E transcription
Within the nucleus, PRDM4 is found in a complex with HDACs (histone deacetylases) 1, 2, and 3. It interacts with the regulatory regions of the cyclin E gene, strongly inhibiting transcription. It was also shown to weakly affect cyclib B transcription. PRDM4 is believed to interact with regulatory regions of other genes, which are unknown.
Literature References
PubMed ID Title Journal Year
15051733 The p75NTR-interacting protein SC1 inhibits cell cycle progression by transcriptional repression of cyclin E

Arevalo, JC, Perez, P, Chittka, A, Sendtner, M, Rodriguez-Guzman, M, Chao, MV

J Cell Biol 2004
Participants
Input
Output
Orthologous Events
PRDM4 inhibits cyclin E transcription (Homo sapiens)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Friedman, WJ  (2008-05-20)
Chao, MV  (2008-05-28)
Created
Jassal, B  (2007-12-06)
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