Nrage activates Jnk1

Stable Identifier
R-RNO-205027
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
General
SVG |   | PPTX  | SBGN
Nrage activates Jnk1

The NGF:p75:NRAGE complex promotes threonine and tyrosine phosphorylation, and activation of JNK, by an unknown mechanism.

Literature References
PubMed ID Title Journal Year
12376548 NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway

Salehi, AH, Xanthoudakis, S, Barker, PA

J Biol Chem 2002
Participants
Catalyst Activity

JUN kinase activity of NGF:p75NTR:Nrage [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
Cite Us!