Production of ceramide which can activate JNK and other targets

Stable Identifier
R-RNO-209562
Type
Reaction
Species
Rattus norvegicus
Compartment
General
SVG |   | PPTX  | SBGN
Production of ceramide which can activate JNK and other targets

Sphingomyielinase promotes the conversion of sphingomyelin to ceramide. Ceramide can activate JNK and other targets. The molecular details of the p75NTR-activated ceramide signalling cascade are only partially understood.

Literature References
PubMed ID Title Journal Year
8079174 Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor

Dobrowsky, RT, Hannun, YA, Castellino, AM, Werner, MH, Chao, MV

Science 1994
Participants
Catalyst Activity

sphingomyelin phosphodiesterase activity of Activated N-SMase (Mg cofactor) [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
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