Reactome | Vamp2 [plasma membrane]

Vamp2 [plasma membrane]

Stable Identifier

R-RNO-210516

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

VAMP2, P63045

Locations in the PathwayBrowser

Expand all

Immune System (Rattus norvegicus)

- Cytokine Signaling in Immune system (Rattus norvegicus)
  - Signaling by Interleukins (Rattus norvegicus)
    - Other interleukin signaling (Rattus norvegicus)
      - TXLNA (IL14) binds syntaxin1A (Rattus norvegicus)
        
        STXA1:SNAP25,STXBP2, VAMP2 [plasma membrane] (Rattus norvegicus)
        
        SNAP25,STXBP2, VAMP2 [plasma membrane] (Rattus norvegicus)
        
        Vamp2 [plasma membrane] (Rattus norvegicus)

Vesicle-mediated transport (Rattus norvegicus)

- Membrane Trafficking (Rattus norvegicus)
  - Clathrin-mediated endocytosis (Rattus norvegicus)
    - BAR domain proteins recruit dynamin (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Rattus norvegicus)
        
        VAMP2,3,8 [plasma membrane] (Rattus norvegicus)
        
        Vamp2 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Rattus norvegicus)
        
        VAMP2,3,8 [plasma membrane] (Rattus norvegicus)
        
        Vamp2 [plasma membrane] (Rattus norvegicus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Rattus norvegicus)
      - CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Rattus norvegicus)
        
        VAMP2,3,8 [plasma membrane] (Rattus norvegicus)
        
        Vamp2 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Rattus norvegicus)
        
        VAMP2,3,8 [plasma membrane] (Rattus norvegicus)
        
        Vamp2 [plasma membrane] (Rattus norvegicus)
    - Cargo recognition for clathrin-mediated endocytosis (Rattus norvegicus)
      - PICALM binds R-SNAREs (Rattus norvegicus)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Rattus norvegicus)
        
        VAMP2,3,8 [plasma membrane] (Rattus norvegicus)
        
        Vamp2 [plasma membrane] (Rattus norvegicus)
        
        VAMP2,3,8 [plasma membrane] (Rattus norvegicus)
        
        Vamp2 [plasma membrane] (Rattus norvegicus)
    - Clathrin recruits PIK3C2A (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Rattus norvegicus)
        
        VAMP2,3,8 [plasma membrane] (Rattus norvegicus)
        
        Vamp2 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Rattus norvegicus)
        
        VAMP2,3,8 [plasma membrane] (Rattus norvegicus)
        
        Vamp2 [plasma membrane] (Rattus norvegicus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Rattus norvegicus)
        
        VAMP2,3,8 [plasma membrane] (Rattus norvegicus)
        
        Vamp2 [plasma membrane] (Rattus norvegicus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Rattus norvegicus)
        
        VAMP2,3,8 [plasma membrane] (Rattus norvegicus)
        
        Vamp2 [plasma membrane] (Rattus norvegicus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Rattus norvegicus)
        
        VAMP2,3,8 [plasma membrane] (Rattus norvegicus)
        
        Vamp2 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Rattus norvegicus)
        
        VAMP2,3,8 [plasma membrane] (Rattus norvegicus)
        
        Vamp2 [plasma membrane] (Rattus norvegicus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Rattus norvegicus)
        
        VAMP2,3,8 [plasma membrane] (Rattus norvegicus)
        
        Vamp2 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Rattus norvegicus)
        
        VAMP2,3,8 [plasma membrane] (Rattus norvegicus)
        
        Vamp2 [plasma membrane] (Rattus norvegicus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Rattus norvegicus)
        
        VAMP2,3,8 [plasma membrane] (Rattus norvegicus)
        
        Vamp2 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Rattus norvegicus)
        
        VAMP2,3,8 [plasma membrane] (Rattus norvegicus)
        
        Vamp2 [plasma membrane] (Rattus norvegicus)
  - trans-Golgi Network Vesicle Budding (Rattus norvegicus)
    - Vamp2 associated secretory vesicle to plasma membrane transport (Rattus norvegicus)
      - Vamp2 [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P63045

Gene Names

Vamp2

Reference Genes

BioGPS Gene:24803 Vamp2

ENSEMBL:ENSRNOG00000006989

ENSEMBL:ENSRNOG00000006989.8 Vamp2

ENSEMBL:ENSRNOG00055032376

ENSEMBL:ENSRNOG00060030134

ENSEMBL:ENSRNOG00065025916

KEGG Gene (Rattus norvegicus):24803 Vamp2

Monarch:24803 Vamp2

NCBI Gene:24803 Vamp2

UCSC:P63045 Vamp2

Reference Transcript

RefSeq:NM_012663.2 Vamp2

Other Identifiers

10734875

1369974_at

17647366

24803

5803718

5939350

6052414

6219619

6350008

6367358

6503118

6533731

6665395

A_44_P447539

GE1167038

GO:0016020

GO:0016192

ILMN_1360798

M24105_at

PH_rn_0012044

rc_AA944789_f_at

rc_AA998361_f_at

rc_AI101103_s_at

Participates

as a member of

VAMP2,3,8 [plasma membrane] (Rattus norvegicus)

as an output of

Vamp2 associated secretory vesicle to plasma membrane transport (Rattus norvegicus)

as a candidate of

SNAP25,STXBP2, VAMP2 [plasma membrane] (Rattus norvegicus)

as a component of

SNARE complex [plasma membrane] (Rattus norvegicus)

Other forms of this molecule

Vamp2 [clathrin-coated endocytic vesicle membrane]

Vamp2 [Golgi membrane]

Vamp2 [lysosomal membrane]

Vamp2 [cytoplasmic vesicle membrane]

Vamp2 [clathrin-sculpted monoamine transport vesicle membrane]

Vamp2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]

Vamp2 [clathrin-sculpted glutamate transport vesicle membrane]

Vamp2 [secretory granule membrane]

Vamp2 [cytosol]

Inferred From

VAMP2 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_036795.1

Ensembl

ENSRNOG00000006989, ENSRNOP00000054114, ENSRNOT00000057295

PRO

P63045

RGD

3949

PDB

6MDM, 3IPD, 3J98, 6WVW, 6MTI, 5W5D, 6A30, 3J99, 7UDB, 2N1T, 1KIL, 5CCG, 6IP1, 5CCH, 1N7S, 3J97, 3J96, 5CCI, 2KOG, 5W5C, 1SFC, 3HD7, 6MDN

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P60881	3	Snap25 [specific granule membrane] (R-RNO-6806154) Snap25 [tertiary granule membrane] (R-RNO-6806142) Snap25 [plasma membrane] (R-RNO-2029017)	0.949	15
UniProt:P32851 Stx1a	2	Stx1a [cytosol] (R-RNO-9609866) Stx1a [plasma membrane] (R-RNO-6794247)	0.752	9
UniProt:Q08850	4	phospho-Stx4 [cytosol] (R-RNO-114681) Stx4 [cytosol] (R-RNO-114505) Stx4 [plasma membrane] (R-RNO-181519) Stx4 [phagocytic vesicle membrane] (R-RNO-2029044)	0.697	8
UniProt:P60881-2 SNAP25			0.667	4
UniProt:P21707	6	SYT1 [clathrin-sculpted monoamine transport vesicle membrane] (R-RNO-372508) SYT1 [plasma membrane] (R-RNO-168786) SYT1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-RNO-917741) SYT1 [clathrin-sculpted glutamate transport vesicle membrane] (R-RNO-372514) SYT1 [clathrin-sculpted acetylcholine transport vesicle membrane] (R-RNO-210536) SYT1 [clathrin-coated endocytic vesicle membrane] (R-RNO-8869113)	0.609	7
UniProt:P07825 SYPH			0.609	5
UniProt:P63041	1	Cplx1 [cytosol] (R-RNO-210385)	0.564	2
UniProt:O70377	4	Snap23 [specific granule membrane] (R-RNO-6806157) Snap23 [plasma membrane] (R-RNO-376345) Snap23 [tertiary granule membrane] (R-RNO-6806141) phospho-Snap23 [phagocytic vesicle membrane] (R-RNO-8863923)	0.564	4
UniProt:O35394 PRAF1			0.527	2
UniProt:P63045	10	Vamp2 [clathrin-coated endocytic vesicle membrane] (R-RNO-8869129) Vamp2 [Golgi membrane] (R-RNO-375425) Vamp2 [lysosomal membrane] (R-RNO-432703) Vamp2 [cytoplasmic vesicle membrane] (R-RNO-1449630) Vamp2 [clathrin-sculpted monoamine transport vesicle membrane] (R-RNO-379363) Vamp2 [plasma membrane] (R-RNO-210516) Vamp2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-RNO-917738) Vamp2 [clathrin-sculpted glutamate transport vesicle membrane] (R-RNO-210365) Vamp2 [secretory granule membrane] (R-RNO-376363) Vamp2 [cytosol] (R-RNO-9609882)	0.524	2
UniProt:P18708 NSF			0.488	2

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