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Mdk [extracellular region]
Stable Identifier
R-RNO-2160953
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
extracellular region
Synonyms
MDK, Q9R1S9
Locations in the PathwayBrowser
Expand all
Signal Transduction (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by ALK (Rattus norvegicus)
ALK autophosphorylation (Rattus norvegicus)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Rattus norvegicus)
ligand-bound ALK dimer [plasma membrane] (Rattus norvegicus)
MDK:ALK dimer [plasma membrane] (Rattus norvegicus)
Mdk [extracellular region] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
MDK:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Mdk [extracellular region] (Rattus norvegicus)
ligand-bound ALK dimer [plasma membrane] (Rattus norvegicus)
MDK:ALK dimer [plasma membrane] (Rattus norvegicus)
Mdk [extracellular region] (Rattus norvegicus)
Active ALK binds JAK3 (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
MDK:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Mdk [extracellular region] (Rattus norvegicus)
Active ALK:JAK3 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
MDK:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Mdk [extracellular region] (Rattus norvegicus)
Active ALK binds PLCG1 (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
MDK:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Mdk [extracellular region] (Rattus norvegicus)
Active ALK:PLCG1 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
MDK:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Mdk [extracellular region] (Rattus norvegicus)
Active ALK binds SHC1 (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
MDK:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Mdk [extracellular region] (Rattus norvegicus)
Active ALK:SHC1 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
MDK:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Mdk [extracellular region] (Rattus norvegicus)
Active ALK dimer binds IRS1 (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
MDK:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Mdk [extracellular region] (Rattus norvegicus)
Active ALK:IRS1 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
MDK:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Mdk [extracellular region] (Rattus norvegicus)
Active ALK phosphorylates IRS1 (Rattus norvegicus)
Active ALK:IRS1 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
MDK:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Mdk [extracellular region] (Rattus norvegicus)
Active ALK:pY-IRS1 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
MDK:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Mdk [extracellular region] (Rattus norvegicus)
Active ALK phosphorylates JAK3 (Rattus norvegicus)
Active ALK:JAK3 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
MDK:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Mdk [extracellular region] (Rattus norvegicus)
Active ALK:p-Y980 JAK3 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
MDK:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Mdk [extracellular region] (Rattus norvegicus)
Active ALK phosphorylates PLCG1 (Rattus norvegicus)
Active ALK:PLCG1 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
MDK:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Mdk [extracellular region] (Rattus norvegicus)
Active ALK:p-4Y PLCG1 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
MDK:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Mdk [extracellular region] (Rattus norvegicus)
Active ALK phosphorylates SHC1 (Rattus norvegicus)
Active ALK:SHC1 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
MDK:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Mdk [extracellular region] (Rattus norvegicus)
Active ALK:p-3Y SHC1 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
MDK:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Mdk [extracellular region] (Rattus norvegicus)
Active ALK recruits PI3K (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
MDK:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Mdk [extracellular region] (Rattus norvegicus)
Active ALK:PI3K [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
MDK:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Mdk [extracellular region] (Rattus norvegicus)
Liganded-ALK dimer binds type I ALK-binding TKIs (Rattus norvegicus)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Rattus norvegicus)
ligand-bound ALK dimer [plasma membrane] (Rattus norvegicus)
MDK:ALK dimer [plasma membrane] (Rattus norvegicus)
Mdk [extracellular region] (Rattus norvegicus)
ligand-bound ALK dimer [plasma membrane] (Rattus norvegicus)
MDK:ALK dimer [plasma membrane] (Rattus norvegicus)
Mdk [extracellular region] (Rattus norvegicus)
MDK and PTN in ALK signaling (Rattus norvegicus)
(PTN,MDK):PTPRZ oligomerizes (Rattus norvegicus)
(PTN,MDK):PTPRZ [plasma membrane] (Rattus norvegicus)
PTN,MDK [extracellular region] (Rattus norvegicus)
Mdk [extracellular region] (Rattus norvegicus)
(PTN,MDK):PTPRZ oligomers [plasma membrane] (Rattus norvegicus)
(PTN,MDK):PTPRZ [plasma membrane] (Rattus norvegicus)
PTN,MDK [extracellular region] (Rattus norvegicus)
Mdk [extracellular region] (Rattus norvegicus)
ALK binds ligand midkine (MDK) (Rattus norvegicus)
MDK:ALK [plasma membrane] (Rattus norvegicus)
Mdk [extracellular region] (Rattus norvegicus)
Mdk [extracellular region] (Rattus norvegicus)
PTN and MDK bind to PTPRZ (Rattus norvegicus)
(PTN,MDK):PTPRZ [plasma membrane] (Rattus norvegicus)
PTN,MDK [extracellular region] (Rattus norvegicus)
Mdk [extracellular region] (Rattus norvegicus)
PTN,MDK [extracellular region] (Rattus norvegicus)
Mdk [extracellular region] (Rattus norvegicus)
PTPRZ dephosphorylates ligand-bound ALK dimers (Rattus norvegicus)
(PTN,MDK):ALK dimer [plasma membrane] (Rattus norvegicus)
MDK:ALK dimer [plasma membrane] (Rattus norvegicus)
Mdk [extracellular region] (Rattus norvegicus)
(PTN,MDK):PTPRZ oligomers [plasma membrane] (Rattus norvegicus)
(PTN,MDK):PTPRZ [plasma membrane] (Rattus norvegicus)
PTN,MDK [extracellular region] (Rattus norvegicus)
Mdk [extracellular region] (Rattus norvegicus)
(PTN,MDK):p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
MDK:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Mdk [extracellular region] (Rattus norvegicus)
PI3K synthesizes PIP3 downstream of ALK (Rattus norvegicus)
Active ALK:PI3K [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
MDK:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Mdk [extracellular region] (Rattus norvegicus)
PTPN6 dephosphorylates JAK3 (Rattus norvegicus)
Active ALK:JAK3 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
MDK:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Mdk [extracellular region] (Rattus norvegicus)
Active ALK:p-Y980 JAK3 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
MDK:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Mdk [extracellular region] (Rattus norvegicus)
STAT3 is phosphorylated downstream of active ALK (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
MDK:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
Mdk [extracellular region] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q9R1S9
Gene Names
Mdk
Reference Genes
BioGPS Gene:81517 Mdk
ENSEMBL:ENSRNOG00000017560
KEGG:rno:81517 Mdk
Monarch:81517 Mdk
NCBI Gene:81517 Mdk
UCSC:Q9R1S9 Mdk
Reference Transcript
RefSeq:XM_006234592.2 Mdk
RefSeq:XM_006234593.5 Mdk
RefSeq:NM_030859.3 Mdk
RefSeq:NM_001413214.1 Mdk
Other Identifiers
10847432
1367682_at
17774581
5970267
6023045
6328065
6476767
6563285
81517
A_43_P15307
A_64_P045671
GE13583
GO:0001662
GO:0002232
GO:0002286
GO:0002376
GO:0002690
GO:0005576
GO:0006355
GO:0007010
GO:0007162
GO:0007614
GO:0008083
GO:0008201
GO:0009611
GO:0010667
GO:0010718
GO:0010759
GO:0010838
GO:0010976
GO:0010996
GO:0021542
GO:0021681
GO:0021766
GO:0021987
GO:0022414
GO:0022600
GO:0030279
GO:0030335
GO:0030421
GO:0032330
GO:0032735
GO:0035374
GO:0035556
GO:0042246
GO:0043524
GO:0044849
GO:0045582
GO:0045590
GO:0045785
GO:0045893
GO:0046850
GO:0048018
GO:0048477
GO:0048714
GO:0048856
GO:0048870
GO:0050729
GO:0050795
GO:0050877
GO:0051781
GO:0061036
GO:0071673
GO:0090023
GO:0090090
GO:0098772
GO:0106015
GO:0106016
GO:0106091
GO:1900026
GO:1903039
GO:1904036
GO:1904399
GO:1904996
GO:1905555
GO:1905564
GO:1905653
GO:2000179
GO:2000347
GO:2000391
GO:2001224
ILMN_1356875
PH_rn_0015970
rc_AI030108_at
Participates
as a member of
PTN,MDK [extracellular region] (Rattus norvegicus)
as a component of
MDK:p-7Y ALK dimer [plasma membrane] (Rattus norvegicus)
MDK:ALK [plasma membrane] (Rattus norvegicus)
MDK:ALK dimer [plasma membrane] (Rattus norvegicus)
MDK [extracellular region] (Rattus norvegicus)
as an input of
ALK binds ligand midkine (MDK) (Rattus norvegicus)
Inferred From
MDK [extracellular region]
(Homo sapiens)
Cross References
RefSeq
XP_006234655.1
,
NP_110486.1
,
XP_006234654.1
,
NP_001400143.1
ENSEMBL
ENSRNOT00000033978
,
ENSRNOP00000036207
,
ENSRNOG00000017560
PRO
Q9R1S9
RGD
69073
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