Reactome | phospho-Wasl [cytosol]

phospho-Wasl [cytosol]

Stable Identifier

R-RNO-2197672

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

p-Y256-WASL, O08816

Locations in the PathwayBrowser

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Immune System (Rattus norvegicus)

- Innate Immune System (Rattus norvegicus)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Rattus norvegicus)
    - Regulation of actin dynamics for phagocytic cup formation (Rattus norvegicus)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Rattus norvegicus)
        
        Mother filament:branching complex [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
        
        p-Y291-WASP/p-Y256-N-WASP [cytosol] (Rattus norvegicus)
        
        phospho-Wasl [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
        
        p-Y291-WASP/p-Y256-N-WASP [cytosol] (Rattus norvegicus)
        
        phospho-Wasl [cytosol] (Rattus norvegicus)
      - Detachment of WASP/WAVE (Rattus norvegicus)
        
        Mother filament:branching complex [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
        
        p-Y291-WASP/p-Y256-N-WASP [cytosol] (Rattus norvegicus)
        
        phospho-Wasl [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
        
        p-Y291-WASP/p-Y256-N-WASP [cytosol] (Rattus norvegicus)
        
        phospho-Wasl [cytosol] (Rattus norvegicus)
      - Src phosphorylate WASP,N-WASP (Rattus norvegicus)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
        
        p-Y291-WASP/p-Y256-N-WASP [cytosol] (Rattus norvegicus)
        
        phospho-Wasl [cytosol] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Rattus norvegicus)
  - Signaling by Rho GTPases (Rattus norvegicus)
    - RHO GTPase Effectors (Rattus norvegicus)
      - RHO GTPases Activate WASPs and WAVEs (Rattus norvegicus)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Rattus norvegicus)
        
        Mother filament:branching complex [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
        
        p-Y291-WASP/p-Y256-N-WASP [cytosol] (Rattus norvegicus)
        
        phospho-Wasl [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
        
        p-Y291-WASP/p-Y256-N-WASP [cytosol] (Rattus norvegicus)
        
        phospho-Wasl [cytosol] (Rattus norvegicus)
        
        Detachment of WASP/WAVE (Rattus norvegicus)
        
        Mother filament:branching complex [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
        
        p-Y291-WASP/p-Y256-N-WASP [cytosol] (Rattus norvegicus)
        
        phospho-Wasl [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
        
        p-Y291-WASP/p-Y256-N-WASP [cytosol] (Rattus norvegicus)
        
        phospho-Wasl [cytosol] (Rattus norvegicus)
        
        Src phosphorylate WASP,N-WASP (Rattus norvegicus)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
        
        p-Y291-WASP/p-Y256-N-WASP [cytosol] (Rattus norvegicus)
        
        phospho-Wasl [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:O08816 Wasl

Gene Names

Wasl

Chain

initiator methionine:1, chain:2-501

Reference Genes

UCSC:O08816 Wasl

Participates

as a member of

p-Y291-WASP/p-Y256-N-WASP [cytosol] (Rattus norvegicus)

Other forms of this molecule

Wasl [endocytic vesicle membrane]

Wasl [plasma membrane]

N-Wasp [cytosol]

Wasl [cytosol]

Inferred From

p-Y256-WASL [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 256 (in Homo sapiens)

Coordinate

256

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

PRO

O08816

RGD

735144

PDB

2IFS, 1MKE

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8X482 ESPFU			0.756	5
UniProt:O08816 Wasl	5	Wasl [plasma membrane] (R-RNO-203010) Wasl [endocytic vesicle membrane] (R-RNO-535012) N-Wasp [cytosol] (R-RNO-442543) phospho-Wasl [cytosol] (R-RNO-2197672) Wasl [cytosol] (R-RNO-201873)	0.73	3
UniProt:P07737 PFN1	2	PFN1 [cytosol] (R-HSA-203081) PFN1 [extracellular region] (R-HSA-350755)	0.639	4
UniProt:P0DJ89 ESFU2			0.618	4
UniProt:P35080 PFN2	1	PFN2 [cytosol] (R-HSA-3009037)	0.602	3
UniProt:Q60598 Cttn	3	Cttn [cytosol] (R-MMU-442836) p-S113-Cttn [cytosol] (R-MMU-442839) Cttn [cytosol] (R-MMU-201894)	0.573	2
UniProt:O43516 WIPF1	1	WIPF1 [cytosol] (R-HSA-201874)	0.558	2
UniProt:Q8IVI9 NOSTRIN	2	NOSTRIN [plasma membrane] (R-HSA-202134) NOSTRIN [endocytic vesicle membrane] (R-HSA-535014)	0.524	3
UniProt:P60953 CDC42	3	CDC42 [cytosol] (R-HSA-442630) CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086) CDC42 [plasma membrane] (R-HSA-449545)	0.524	2

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