Reactome | Klrd1 [plasma membrane]

Klrd1 [plasma membrane]

Stable Identifier

R-RNO-2326854

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

KLRD1, O35778

Locations in the PathwayBrowser

Expand all

Immune System (Rattus norvegicus)

- Innate Immune System (Rattus norvegicus)
  - DAP12 interactions (Rattus norvegicus)
    - DAP12 interacts with NKG2C (Rattus norvegicus)
      - CD94:NKG2C:HLA-E [plasma membrane] (Rattus norvegicus)
        
        CD94:NKG2C [plasma membrane] (Rattus norvegicus)
        
        Klrd1 [plasma membrane] (Rattus norvegicus)
      - HLA-E:CD94:NKG2C:DAP12 [plasma membrane] (Rattus norvegicus)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Rattus norvegicus)
        
        CD94:NKG2C [plasma membrane] (Rattus norvegicus)
        
        Klrd1 [plasma membrane] (Rattus norvegicus)
    - DAP12 signaling (Rattus norvegicus)
      - PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Rattus norvegicus)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Rattus norvegicus)
        
        DAP12 receptors [plasma membrane] (Rattus norvegicus)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Rattus norvegicus)
        
        CD94:NKG2C [plasma membrane] (Rattus norvegicus)
        
        Klrd1 [plasma membrane] (Rattus norvegicus)
      - Phosphorylation and activation of VAV2/VAV3 by SYK (Rattus norvegicus)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Rattus norvegicus)
        
        DAP12 receptors [plasma membrane] (Rattus norvegicus)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Rattus norvegicus)
        
        CD94:NKG2C [plasma membrane] (Rattus norvegicus)
        
        Klrd1 [plasma membrane] (Rattus norvegicus)
      - Phosphorylation of BTK by p-SYK (Rattus norvegicus)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Rattus norvegicus)
        
        DAP12 receptors [plasma membrane] (Rattus norvegicus)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Rattus norvegicus)
        
        CD94:NKG2C [plasma membrane] (Rattus norvegicus)
        
        Klrd1 [plasma membrane] (Rattus norvegicus)
      - Phosphorylation of LAT by p-SYK (Rattus norvegicus)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Rattus norvegicus)
        
        DAP12 receptors [plasma membrane] (Rattus norvegicus)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Rattus norvegicus)
        
        CD94:NKG2C [plasma membrane] (Rattus norvegicus)
        
        Klrd1 [plasma membrane] (Rattus norvegicus)
      - Phosphorylation of PLC-gamma by p-BTK/p-SYK (Rattus norvegicus)
        
        p-SYK/p-BTK [plasma membrane] (Rattus norvegicus)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Rattus norvegicus)
        
        DAP12 receptors [plasma membrane] (Rattus norvegicus)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Rattus norvegicus)
        
        CD94:NKG2C [plasma membrane] (Rattus norvegicus)
        
        Klrd1 [plasma membrane] (Rattus norvegicus)
      - Phosphorylation of SLP-76 by p-SYK (Rattus norvegicus)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Rattus norvegicus)
        
        DAP12 receptors [plasma membrane] (Rattus norvegicus)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Rattus norvegicus)
        
        CD94:NKG2C [plasma membrane] (Rattus norvegicus)
        
        Klrd1 [plasma membrane] (Rattus norvegicus)
      - Phosphorylation of SYK (Rattus norvegicus)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Rattus norvegicus)
        
        DAP12 receptors [plasma membrane] (Rattus norvegicus)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Rattus norvegicus)
        
        CD94:NKG2C [plasma membrane] (Rattus norvegicus)
        
        Klrd1 [plasma membrane] (Rattus norvegicus)
        
        DAP12 receptors:p-DAP12:SYK [plasma membrane] (Rattus norvegicus)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Rattus norvegicus)
        
        DAP12 receptors [plasma membrane] (Rattus norvegicus)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Rattus norvegicus)
        
        CD94:NKG2C [plasma membrane] (Rattus norvegicus)
        
        Klrd1 [plasma membrane] (Rattus norvegicus)
      - Recruitment of SYK to p-DAP12 (Rattus norvegicus)
        
        DAP12 receptors:p-DAP12:SYK [plasma membrane] (Rattus norvegicus)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Rattus norvegicus)
        
        DAP12 receptors [plasma membrane] (Rattus norvegicus)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Rattus norvegicus)
        
        CD94:NKG2C [plasma membrane] (Rattus norvegicus)
        
        Klrd1 [plasma membrane] (Rattus norvegicus)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Rattus norvegicus)
        
        DAP12 receptors [plasma membrane] (Rattus norvegicus)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Rattus norvegicus)
        
        CD94:NKG2C [plasma membrane] (Rattus norvegicus)
        
        Klrd1 [plasma membrane] (Rattus norvegicus)
      - p85 regulatory unit of PI3K binds p-6Y-SYK (Rattus norvegicus)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Rattus norvegicus)
        
        DAP12 receptors [plasma membrane] (Rattus norvegicus)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Rattus norvegicus)
        
        CD94:NKG2C [plasma membrane] (Rattus norvegicus)
        
        Klrd1 [plasma membrane] (Rattus norvegicus)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Rattus norvegicus)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Rattus norvegicus)
        
        DAP12 receptors [plasma membrane] (Rattus norvegicus)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Rattus norvegicus)
        
        CD94:NKG2C [plasma membrane] (Rattus norvegicus)
        
        Klrd1 [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:O35778

Gene Names

Klrd1

Reference Genes

BioGPS Gene:25110 Klrd1

ENSEMBL:ENSRNOG00000060246

ENSEMBL:ENSRNOG00000060246.2 Klrd1

ENSEMBL:ENSRNOG00055024701

ENSEMBL:ENSRNOG00060016054

ENSEMBL:ENSRNOG00065033801

KEGG Gene (Rattus norvegicus):25110 Klrd1

Monarch:25110 Klrd1

NCBI Gene:25110 Klrd1

UCSC:O35778 Klrd1

Reference Transcript

RefSeq:NM_012745.2 Klrd1

Other Identifiers

10859164

1369306_at

17787604

25110

5703412

5737935

5836931

5905295

6189435

6355095

6372003

6500777

6568978

AF009133_at

A_43_P11543

A_64_P161388

GE19937

GE21301

ILMN_1357215

PH_rn_0005073

Participates

as a component of

CD94:NKG2C [plasma membrane] (Rattus norvegicus)

Inferred From

KLRD1 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_036877.1

Ensembl

ENSRNOP00000074715, ENSRNOT00000082064, ENSRNOG00000060246

PRO

O35778

RGD

2978

Cite Us!