MeSeH is methylated to Me2Se by MeSeH methyltransferase

Stable Identifier
R-RNO-2408501
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MeSeH is methylated to Me2Se by MeSeH methyltransferase
In the rat cytosol, a yet to be identified enzyme with methylselenol methyltransferase (Mesehmt) activity is involved in the methylation of methylselenol aka methaneselenol (MeSeH) into dimethyl selenide (Me2Se) in tandem with S-adenosylmethionine (AdoMet) transforming into S-adenosylhomocysteine (AdoHcy) (Ohta and Suzuki 2008, Hsieh and Ganther 1977).
Literature References
PubMed ID Title Journal Year
17988700 Methylation and demethylation of intermediates selenide and methylselenol in the metabolism of selenium

Ohta, Y, Suzuki, KT

Toxicol. Appl. Pharmacol. 2008
14705 Biosynthesis of dimethyl selenide from sodium selenite in rat liver and kidney cell-free systems

Hsieh, HS, Ganther, HE

Biochim. Biophys. Acta 1977
Participants
Input
Output
Catalyst Activity

methaneselenol methyltransferase activity of Mesehmt [cytosol]

Physical Entity
Mesehmt [cytosol] (Rattus norvegicus)
Activity
methaneselenol methyltransferase activity (GO:0098613)
Orthologous Events
MeSeH is methylated to Me2Se by MeSeH methyltransferase (Homo sapiens)
Authored
Williams, MG  (2014-05-06)
Reviewed
Rush, MG  (2015-08-30)
Created
Williams, MG  (2012-07-17)
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