Reactome | Irs1 [plasma membrane]

Irs1 [plasma membrane]

Stable Identifier

R-RNO-2425392

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

IRS1, P35570

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P35570 Irs1

Gene Names

Irs1, Irs-1

Chain

chain:1-1235

Reference Genes

BioGPS Gene:25467 Irs1

KEGG Gene (Rattus norvegicus):25467 Irs1

Monarch:25467 Irs1

NCBI Gene:25467 Irs1

UCSC:P35570 Irs1

Reference Transcript

RefSeq:NM_012969.1 Irs1

Participates

as an input of

IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Rattus norvegicus)

as a component of

IGF1,2:p-IGF1R:IRS1,4 [plasma membrane] (Rattus norvegicus)

as a member of

IRS1,2,4 [plasma membrane] (Rattus norvegicus)

Other forms of this molecule

Irs1 [cytosol]

phospho-Irs1 [plasma membrane]

p-Y-Irs1 [cytosol]

Irs1 [cytosol]

phospho-Irs1 [cytosol]

phospho-Irs1 [plasma membrane]

Inferred From

IRS1,4 [plasma membrane] (Homo sapiens)

IRS1 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_037101.1

PRO

P35570

RGD

2922

PDB

5WRK, 5WRL, 5WRM

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06213 INSR	6	p-6Y-INSR(763-1382) [endosome membrane] (R-HSA-141719) INSR(763-1382) [endosome membrane] (R-HSA-141722) INSR(28-758) [endosome membrane] (R-HSA-141718) INSR(763-1382) [plasma membrane] (R-HSA-74669) p-6Y-INSR(763-1382) [plasma membrane] (R-HSA-74670) INSR(28-758) [plasma membrane] (R-HSA-74668)	0.791	5
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.737	5
UniProt:Q06124 PTPN11	4	p-Y542-PTPN11 [cytosol] (R-HSA-1369081) PTPN11 [nucleoplasm] (R-HSA-8937745) PTPN11 [cytosol] (R-HSA-162563) p-Y542,Y580-PTPN11 [cytosol] (R-HSA-162573)	0.656	3
UniProt:Q63787 Pik3r1	4	Pik3r1 [cytosol] (R-RNO-3080572) Pi3k-p85 [cytosol] (R-RNO-912643) Pik3r1 [cytosol] (R-RNO-74789) Pik3r1 [plasma membrane] (R-RNO-198365)	0.589	2
UniProt:Q13625-2 TP53BP2			0.567	4
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.564	2
UniProt:P18031 PTPN1	2	PTPN1 [cytosol] (R-HSA-210625) PTPN1 [endosome membrane] (R-HSA-9815895)	0.525	3
UniProt:Q8VDD9	1	Phip [cytosol] (R-MMU-9715153)	0.508	2
UniProt:P39688 Fyn	6	Fyn [cytosol] (R-MMU-420333) phospho-MyrG-p-Y420-FYN-1 [plasma membrane] (R-MMU-9032530) pFyn (420) [cytosol] (R-MMU-420335) pFyn(Y531) [cytosol] (R-MMU-420350) phospho-p-S21,Y420-FYN [cytosol] (R-MMU-5218745) MyrG,p-Y420-Fyn [plasma membrane] (R-MMU-9037733)	0.462	4

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