Reactome | Casp2 [cytosol]

Casp2 [cytosol]

Stable Identifier

R-RNO-2976746

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

CASP2(170-325), P55215

Locations in the PathwayBrowser

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Gene expression (Transcription) (Rattus norvegicus)

- RNA Polymerase II Transcription (Rattus norvegicus)
  - Generic Transcription Pathway (Rattus norvegicus)
    - Transcriptional Regulation by TP53 (Rattus norvegicus)
      - TP53 Regulates Transcription of Cell Death Genes (Rattus norvegicus)
        
        TP53 Regulates Transcription of Caspase Activators and Caspases (Rattus norvegicus)
        
        The PIDDosome activates CASP2 (Rattus norvegicus)
        
        Casp2 [cytosol] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- Death Receptor Signaling (Rattus norvegicus)
  - p75 NTR receptor-mediated signalling (Rattus norvegicus)
    - Cell death signalling via NRAGE, NRIF and NADE (Rattus norvegicus)
      - NADE modulates death signalling (Rattus norvegicus)
        
        p75NTR:NADE promotes caspase2/3 activation (Rattus norvegicus)
        
        Active Caspases 2, 3 [cytosol] (Rattus norvegicus)
        
        Active Caspase-2 heterotetramer [cytosol] (Rattus norvegicus)
        
        Caspase-2 [cytosol] (Rattus norvegicus)
        
        Casp2 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P55215

Gene Names

Casp2

Reference Genes

BioGPS Gene:64314 Casp2

ENSEMBL:ENSRNOG00000016707

ENSEMBL:ENSRNOG00000016707.8 Casp2

ENSEMBL:ENSRNOG00055028158

ENSEMBL:ENSRNOG00060008547

ENSEMBL:ENSRNOG00065016049

KEGG Gene (Rattus norvegicus):64314 Casp2

Monarch:64314 Casp2

NCBI Gene:64314 Casp2

UCSC:P55215 Casp2

Reference Transcript

RefSeq:NM_022522.2 Casp2

Other Identifiers

10855020

1367890_at

1367891_a_at

17782997

5641353

5783850

5806975

5961463

5994470

6023268

6112088

6173447

6173960

6180131

6192554

6327532

6405511

64314

6473223

6639029

6743996

AF025671_s_at

A_44_P1019923

A_64_P158644

A_64_P164041

GE22053

GO:0000278

GO:0003824

GO:0004197

GO:0005634

GO:0005737

GO:0006508

GO:0006977

GO:0008234

GO:0012501

GO:0016485

GO:0016787

GO:0019904

GO:0022414

GO:0023052

GO:0030154

GO:0035234

GO:0042802

GO:0042981

GO:0043065

GO:0043226

GO:0048856

GO:0051604

GO:0071260

GO:0097153

GO:0097190

GO:0097192

GO:0097200

GO:0140096

GO:1905369

GO:2001235

ILMN_1349906

PH_rn_0011241

PH_rn_0019864

U34684_s_at

U77933_at

Participates

as an output of

The PIDDosome activates CASP2 (Rattus norvegicus)

as a component of

Caspase-2 [cytosol] (Rattus norvegicus)

Other forms of this molecule

Casp2 [cytosol]

Inferred From

CASP2(170-325) [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_071967.2

IntEnz

3.4.22.55

Ensembl

ENSRNOG00000016707, ENSRNOP00000022672, ENSRNOT00000022672

PRO

P55215

RGD

69274

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