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Lef1 [nucleoplasm]
Stable Identifier
R-RNO-3214972
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
nucleoplasm
Synonyms
LEF1, Q9QXN1
Locations in the PathwayBrowser
Expand all
Developmental Biology (Rattus norvegicus)
MITF-M-regulated melanocyte development (Rattus norvegicus)
MITF-M-dependent gene expression (Rattus norvegicus)
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation (Rattus norvegicus)
HINT1, HDAC1, and SIN3A bind CTNNB1 at the CCND1 promoter (Rattus norvegicus)
HINT1:HDAC1:SIN3A:TCF/LEF:CTNNB1:CCND1 gene [nucleoplasm] (Rattus norvegicus)
TCF/LEF:CTNNB1:CCND1 gene [nucleoplasm] (Rattus norvegicus)
TCF/LEF:CTNNB1 [nucleoplasm] (Rattus norvegicus)
TCF/LEF [nucleoplasm] (Rattus norvegicus)
Lef1 [nucleoplasm] (Rattus norvegicus)
TCF/LEF:CTNNB1:CCND1 gene [nucleoplasm] (Rattus norvegicus)
TCF/LEF:CTNNB1 [nucleoplasm] (Rattus norvegicus)
TCF/LEF [nucleoplasm] (Rattus norvegicus)
Lef1 [nucleoplasm] (Rattus norvegicus)
Gene expression (Transcription) (Rattus norvegicus)
RNA Polymerase II Transcription (Rattus norvegicus)
Generic Transcription Pathway (Rattus norvegicus)
Transcriptional regulation by RUNX3 (Rattus norvegicus)
RUNX3 regulates WNT signaling (Rattus norvegicus)
RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Rattus norvegicus)
CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Rattus norvegicus)
TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Rattus norvegicus)
Lef1 [nucleoplasm] (Rattus norvegicus)
RUNX3:CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Rattus norvegicus)
CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Rattus norvegicus)
TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Rattus norvegicus)
Lef1 [nucleoplasm] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Signaling by WNT (Rattus norvegicus)
Beta-catenin independent WNT signaling (Rattus norvegicus)
Ca2+ pathway (Rattus norvegicus)
NLK phosphorylates TCF/LEF (Rattus norvegicus)
TCF/LEF:CTNNB1 [nucleoplasm] (Rattus norvegicus)
TCF7L2,LEF1 [nucleoplasm] (Rattus norvegicus)
Lef1 [nucleoplasm] (Rattus norvegicus)
Degradation of beta-catenin by the destruction complex (Rattus norvegicus)
Repression of WNT target genes (Rattus norvegicus)
TLE tetramers bind TCF/LEF at WNT promoters (Rattus norvegicus)
'canonical' WNT target gene:TCF/LEF:TLE tetramer [nucleoplasm] (Rattus norvegicus)
'canonical' WNT target genes:TCF/LEF [nucleoplasm] (Rattus norvegicus)
TCF/LEF [nucleoplasm] (Rattus norvegicus)
Lef1 [nucleoplasm] (Rattus norvegicus)
'canonical' WNT target genes:TCF/LEF [nucleoplasm] (Rattus norvegicus)
TCF/LEF [nucleoplasm] (Rattus norvegicus)
Lef1 [nucleoplasm] (Rattus norvegicus)
TCF dependent signaling in response to WNT (Rattus norvegicus)
Deactivation of the beta-catenin transactivating complex (Rattus norvegicus)
TCF:Beta-catenin binds SOX proteins (Rattus norvegicus)
TCF/LEF:CTNNB1 [nucleoplasm] (Rattus norvegicus)
TCF/LEF [nucleoplasm] (Rattus norvegicus)
Lef1 [nucleoplasm] (Rattus norvegicus)
TCF/LEF:CTNNB1:SOX4,SOX13,SOX17 [nucleoplasm] (Rattus norvegicus)
TCF/LEF:CTNNB1 [nucleoplasm] (Rattus norvegicus)
TCF/LEF [nucleoplasm] (Rattus norvegicus)
Lef1 [nucleoplasm] (Rattus norvegicus)
beta-catenin is replaced by repression complexes at the promoter (Rattus norvegicus)
TCF/LEF:CTNNB1:APC:CTBP:BTRC [nucleoplasm] (Rattus norvegicus)
TCF/LEF [nucleoplasm] (Rattus norvegicus)
Lef1 [nucleoplasm] (Rattus norvegicus)
TCF/LEF:TLE:HDAC1 [nucleoplasm] (Rattus norvegicus)
TCF/LEF [nucleoplasm] (Rattus norvegicus)
Lef1 [nucleoplasm] (Rattus norvegicus)
Formation of the beta-catenin:TCF transactivating complex (Rattus norvegicus)
Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Rattus norvegicus)
TCF/LEF:CTNNB1 [nucleoplasm] (Rattus norvegicus)
TCF/LEF [nucleoplasm] (Rattus norvegicus)
Lef1 [nucleoplasm] (Rattus norvegicus)
TCF/LEF:TLE:HDAC1 [nucleoplasm] (Rattus norvegicus)
TCF/LEF [nucleoplasm] (Rattus norvegicus)
Lef1 [nucleoplasm] (Rattus norvegicus)
Beta-catenin recruits CBP/p300 (Rattus norvegicus)
TCF/LEF:CTNNB1 [nucleoplasm] (Rattus norvegicus)
TCF/LEF [nucleoplasm] (Rattus norvegicus)
Lef1 [nucleoplasm] (Rattus norvegicus)
TCF/LEF:CTNNB1:CBP/p300 [nucleoplasm] (Rattus norvegicus)
TCF/LEF:CTNNB1 [nucleoplasm] (Rattus norvegicus)
TCF/LEF [nucleoplasm] (Rattus norvegicus)
Lef1 [nucleoplasm] (Rattus norvegicus)
Beta-catenin recruits CDC73 and LEO1 (Rattus norvegicus)
TCF/LEF:CTNNB1 [nucleoplasm] (Rattus norvegicus)
TCF/LEF [nucleoplasm] (Rattus norvegicus)
Lef1 [nucleoplasm] (Rattus norvegicus)
TCF/LEF:CTNNB1:PAF1-like complex [nucleoplasm] (Rattus norvegicus)
TCF/LEF:CTNNB1 [nucleoplasm] (Rattus norvegicus)
TCF/LEF [nucleoplasm] (Rattus norvegicus)
Lef1 [nucleoplasm] (Rattus norvegicus)
Beta-catenin recruits SMARCA4 (Rattus norvegicus)
TCF/LEF:CTNNB1 [nucleoplasm] (Rattus norvegicus)
TCF/LEF [nucleoplasm] (Rattus norvegicus)
Lef1 [nucleoplasm] (Rattus norvegicus)
TCF/LEF:CTNNB1:SMARCA4:TERT [nucleoplasm] (Rattus norvegicus)
TCF/LEF:CTNNB1 [nucleoplasm] (Rattus norvegicus)
TCF/LEF [nucleoplasm] (Rattus norvegicus)
Lef1 [nucleoplasm] (Rattus norvegicus)
Beta-catenin recruits TRRAP/KAT5 HAT components (Rattus norvegicus)
TCF/LEF:CTNNB1 [nucleoplasm] (Rattus norvegicus)
TCF/LEF [nucleoplasm] (Rattus norvegicus)
Lef1 [nucleoplasm] (Rattus norvegicus)
TCF/LEF:CTNNB1:RUVBL1:TRRAP:KAT5 [nucleoplasm] (Rattus norvegicus)
TCF/LEF:CTNNB1 [nucleoplasm] (Rattus norvegicus)
TCF/LEF [nucleoplasm] (Rattus norvegicus)
Lef1 [nucleoplasm] (Rattus norvegicus)
Beta-catenin:TCF associates with BCL9 and PYGO (Rattus norvegicus)
TCF/LEF:CTNNB1 [nucleoplasm] (Rattus norvegicus)
TCF/LEF [nucleoplasm] (Rattus norvegicus)
Lef1 [nucleoplasm] (Rattus norvegicus)
TCF/LEF:CTNNB1:BCL9:PYGO [nucleoplasm] (Rattus norvegicus)
TCF/LEF [nucleoplasm] (Rattus norvegicus)
Lef1 [nucleoplasm] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q9QXN1 Lef1
Gene Names
Lef1
Chain
chain:1-397
Reference Genes
BioGPS Gene:161452 Lef1
KEGG Gene (Rattus norvegicus):161452 Lef1
Monarch:161452 Lef1
NCBI Gene:161452 Lef1
Reference Transcript
RefSeq:NM_130429.1 Lef1
Participates
as a member of
TCF/LEF [nucleoplasm] (Rattus norvegicus)
TCF/LEF [nucleoplasm] (Rattus norvegicus)
TCF7L2,LEF1 [nucleoplasm] (Rattus norvegicus)
as a candidate of
TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Rattus norvegicus)
TCF7L1/TCF7L2/LEF1 [nucleoplasm] (Rattus norvegicus)
Other forms of this molecule
phospho-Lef1 [nucleoplasm]
Lef1 [nucleoplasm]
Inferred From
LEF1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_569113.1
PRO
Q9QXN1
RGD
620241
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