Reactome | Chd4 [nucleoplasm]

Chd4 [nucleoplasm]

Stable Identifier

R-RNO-3702078

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

nucleoplasm

Synonyms

CHD4, E9PU01

Locations in the PathwayBrowser

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Chromatin organization (Rattus norvegicus)

- Chromatin modifying enzymes (Rattus norvegicus)
  - HDACs deacetylate histones (Rattus norvegicus)
    - HDAC1:2-containing complex binds HDAC2 Inhibitors (Rattus norvegicus)
      - HDAC1:2-containing complex [nucleoplasm] (Rattus norvegicus)
        
        NuRD complex [nucleoplasm] (Rattus norvegicus)
        
        Mi-2 [nucleoplasm] (Rattus norvegicus)
        
        Chd4 [nucleoplasm] (Rattus norvegicus)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Rattus norvegicus)
        
        HDAC1:2-containing complex [nucleoplasm] (Rattus norvegicus)
        
        NuRD complex [nucleoplasm] (Rattus norvegicus)
        
        Mi-2 [nucleoplasm] (Rattus norvegicus)
        
        Chd4 [nucleoplasm] (Rattus norvegicus)

Gene expression (Transcription) (Rattus norvegicus)

- RNA Polymerase I Transcription (Rattus norvegicus)
  - RNA Polymerase I Promoter Clearance (Rattus norvegicus)
    - RNA Polymerase I Transcription Initiation (Rattus norvegicus)
      - Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Rattus norvegicus)
        
        TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Rattus norvegicus)
        
        NuRD complex [nucleoplasm] (Rattus norvegicus)
        
        Mi-2 [nucleoplasm] (Rattus norvegicus)
        
        Chd4 [nucleoplasm] (Rattus norvegicus)
- RNA Polymerase II Transcription (Rattus norvegicus)
  - Generic Transcription Pathway (Rattus norvegicus)
    - Transcriptional Regulation by TP53 (Rattus norvegicus)
      - Regulation of TP53 Activity (Rattus norvegicus)
        
        Regulation of TP53 Activity through Acetylation (Rattus norvegicus)
        
        MTA2-NuRD complex deacetylates TP53 (Rattus norvegicus)
        
        MTA2-NuRD complex [nucleoplasm] (Rattus norvegicus)
        
        Mi-2 [nucleoplasm] (Rattus norvegicus)
        
        Chd4 [nucleoplasm] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- Intracellular signaling by second messengers (Rattus norvegicus)
  - PIP3 activates AKT signaling (Rattus norvegicus)
    - PTEN Regulation (Rattus norvegicus)
      - Regulation of PTEN gene transcription (Rattus norvegicus)
        
        SALL4 recruits NuRD to PTEN gene (Rattus norvegicus)
        
        NuRD complex [nucleoplasm] (Rattus norvegicus)
        
        Mi-2 [nucleoplasm] (Rattus norvegicus)
        
        Chd4 [nucleoplasm] (Rattus norvegicus)
        
        SALL4:NuRD:PTEN gene [nucleoplasm] (Rattus norvegicus)
        
        SALL4:NuRD [nucleoplasm] (Rattus norvegicus)
        
        NuRD complex [nucleoplasm] (Rattus norvegicus)
        
        Mi-2 [nucleoplasm] (Rattus norvegicus)
        
        Chd4 [nucleoplasm] (Rattus norvegicus)
- Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
  - Signaling by NTRKs (Rattus norvegicus)
    - Signaling by NTRK1 (TRKA) (Rattus norvegicus)
      - Nuclear Events (kinase and transcription factor activation) (Rattus norvegicus)
        
        NGF-stimulated transcription (Rattus norvegicus)
        
        NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Rattus norvegicus)
        
        Chd4 [nucleoplasm] (Rattus norvegicus)
        
        RRAD gene:EGR2:NAB2:CHD4 [nucleoplasm] (Rattus norvegicus)
        
        Chd4 [nucleoplasm] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:E9PU01

Gene Names

Chd4

Reference Genes

BioGPS Gene:117535 Chd4

ENSEMBL:ENSRNOG00000018309

ENSEMBL:ENSRNOG00000018309.8 Chd4

Monarch:117535 Chd4

NCBI Gene:117535 Chd4

Reference Transcript

RefSeq:XM_006237401.3 Chd4

Other Identifiers

10858784

117535

1372441_at

1385779_at

1397200_at

17787205

5677255

5684827

5713135

5735034

5748766

5750288

5825924

5883870

5889179

6007130

6032243

6032245

6038862

6090930

6103252

6105814

6123172

6134220

6144053

6160842

6160897

6231768

6237322

6247972

6254666

6261368

6270301

6304596

6348782

6355588

6360403

6386113

6399224

6436478

6436810

6439091

6443884

6473640

6495613

6506168

6509298

6520862

6573076

6575745

6728130

6734556

A_43_P11241

A_44_P159292

A_44_P454372

A_64_P002086

A_64_P152587

GE17380

GO:0000724

GO:0000781

GO:0001221

GO:0003677

GO:0003714

GO:0003824

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005813

GO:0005815

GO:0005856

GO:0006281

GO:0006310

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0010629

GO:0016581

GO:0016787

GO:0016887

GO:0042826

GO:0043226

GO:0061629

GO:0090575

GO:0090734

GO:0140097

GO:0140110

GO:0140657

GO:0140658

ILMN_1359896

PH_rn_0001644

rc_AA956746_at

Participates

as an input of

NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Rattus norvegicus)

as a component of

RRAD gene:EGR2:NAB2:CHD4 [nucleoplasm] (Rattus norvegicus)

as a member of

Mi-2 [nucleoplasm] (Rattus norvegicus)

Inferred From

CHD4 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_006237463.1

Ensembl

ENSRNOT00000055970, ENSRNOG00000018309, ENSRNOP00000052823

RGD

620064

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