Ankyrins link voltage-gated sodium and pottasium channels to spectrin and L1

Stable Identifier
Reaction [binding]
Rattus norvegicus
SVG |   | PPTX  | SBGN
Ankyrins link voltage-gated sodium and pottasium channels to spectrin and L1

Ankyrins link both L1 and ion channel proteins, coupling them to the spectrin actin cytoskeleton. In the nervous system ankyrins interact with voltage gated channels and cluster them in axon initial segments to generate action potentials. At these points the actin spectrin network is linked via ankyrins to voltage gated sodium channels, L1, and the voltage gated potassium ion channel subunits, KCNQ2 and KCNQ3.

Literature References
PubMed ID Title Journal Year
9278538 Morphogenesis of the node of Ranvier: co-clusters of ankyrin and ankyrin-binding integral proteins define early developmental intermediates

Lambert, S, Davis, JQ, Bennett, V

J Neurosci 1997
11427698 Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues

Bennett, V, Baines, AJ

Physiol Rev 2001
16525039 A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon

Pan, Z, Kao, T, Horvath, Z, Lemos, J, Sul, JY, Cranstoun, SD, Bennett, V, Scherer, SS, Cooper, EC

J Neurosci 2006
11724816 Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments

Jenkins, SM, Bennett, V

J Cell Biol 2001
11470829 Sodium channel beta1 and beta3 subunits associate with neurofascin through their extracellular immunoglobulin-like domain

Ratcliffe, CF, Westenbroek, RE, Curtis, R, Catterall, WA

J Cell Biol 2001
19112491 Ion channel clustering at the axon initial segment and node of Ranvier evolved sequentially in early chordates

Hill, AS, Nishino, A, Nakajo, K, Zhang, G, Fineman, JR, Selzer, ME, Okamura, Y, Cooper, EC

PLoS Genet 2008
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