Reactome | phospho-Dcc [plasma membrane]

phospho-Dcc [plasma membrane]

Stable Identifier

R-RNO-374552

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

p-Y1420-DCC, Q63155

Locations in the PathwayBrowser

Expand all

Developmental Biology (Rattus norvegicus)

- Nervous system development (Rattus norvegicus)
  - Axon guidance (Rattus norvegicus)
    - Netrin-1 signaling (Rattus norvegicus)
      - DCC mediated attractive signaling (Rattus norvegicus)
        
        Activation of Cdc42 (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer [plasma membrane] (Rattus norvegicus)
        
        phospho-Dcc [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer [plasma membrane] (Rattus norvegicus)
        
        phospho-Dcc [plasma membrane] (Rattus norvegicus)
        
        Activation of Rac1 (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer [plasma membrane] (Rattus norvegicus)
        
        phospho-Dcc [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:RAC1:GTP [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer [plasma membrane] (Rattus norvegicus)
        
        phospho-Dcc [plasma membrane] (Rattus norvegicus)
        
        DCC interacting NCK-1 (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer [plasma membrane] (Rattus norvegicus)
        
        phospho-Dcc [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer [plasma membrane] (Rattus norvegicus)
        
        phospho-Dcc [plasma membrane] (Rattus norvegicus)
        
        Phosphorylation of DCC by Fyn (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer [plasma membrane] (Rattus norvegicus)
        
        phospho-Dcc [plasma membrane] (Rattus norvegicus)
        
        RhoGTPase GEF's recruited to DCC (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer [plasma membrane] (Rattus norvegicus)
        
        phospho-Dcc [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer [plasma membrane] (Rattus norvegicus)
        
        phospho-Dcc [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q63155 Dcc

Gene Names

Dcc

Chain

signal peptide:1-25, chain:26-1445

Reference Genes

BioGPS Gene:25311 Dcc

KEGG Gene (Rattus norvegicus):25311 Dcc

Monarch:25311 Dcc

NCBI Gene:25311 Dcc

Reference Transcript

RefSeq:NM_012841.1 Dcc

Participates

as a component of

NTN1:p-Y1420-DCC oligomer [plasma membrane] (Rattus norvegicus)

Other forms of this molecule

DCC [plasma membrane]

Dcc [cytosol]

Dcc [plasma membrane]

Inferred From

p-Y1420-DCC [plasma membrane] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 1420 (in Homo sapiens)

Coordinate

1420

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_036973.1

PRO

Q63155

RGD

2492

PDB

3O71, 3LAF, 5Z5K, 6BZ3

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63086 Mapk1	10	MAPK1 [azurophil granule lumen] (R-RNO-6799225) MAPK1 [extracellular region] (R-RNO-6806250) MAPK1 [ficolin-1-rich granule lumen] (R-RNO-6800964) Erk2 [cytosol] (R-RNO-206232) phospho-p-T185-MAPK1 [cytosol] (R-RNO-9635773) p-T183,Y185-Mapk1 [nucleoplasm] (R-RNO-205803) MAPK1 [nucleoplasm] (R-RNO-199960) MAPK1 [cytosol] (R-RNO-59282) phospho-p-T185,Y187-MAPK1 [cytosol] (R-RNO-109853) phospho-p-T185,Y187-MAPK1 [nucleoplasm] (R-RNO-112354)	0.706	10
UniProt:P46777 RPL5	1	RPL5 [cytosol] (R-HSA-72482)	0.619	4
UniProt:Q9HD67 MYO10	1	MYO10 [cytosol] (R-HSA-593679)	0.544	3
UniProt:O55005 Robo1	1	ROBO1_RAT [plasma membrane] (R-RNO-428460)	0.524	2
UniProt:P15311 EZR	3	p-Y146,Y354-EZR [cytosol] (R-HSA-374572) p-T567-EZR [cytosol] (R-HSA-374559) EZR [cytosol] (R-HSA-9020826)	0.524	3
UniProt:Q8CGU4 Agap2	1	PIKE-L_RAT [cytosol] (R-RNO-622356)	0.524	2
UniProt:P31977 Ezr	4	Ezr [cytosol] (R-RNO-9020826) phospho-Ezr [cytosol] (R-RNO-374559) EZRI_RAT [cytosol] (R-RNO-443600) phospho-Ezr [cytosol] (R-RNO-374572)	0.499	2
UniProt:Q9ERC8 Dscam	2	Dscam [plasma membrane] (R-MMU-451372) Dscam [plasma membrane] (R-MMU-197881)	0.499	4

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