Reactome | Spc24 [cytosol]

Spc24 [cytosol]

Stable Identifier

R-RNO-375297

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

SPC24, D4A1C5

Locations in the PathwayBrowser

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Cell Cycle (Rattus norvegicus)

- Cell Cycle Checkpoints (Rattus norvegicus)
  - Mitotic Spindle Checkpoint (Rattus norvegicus)
    - Amplification of signal from the kinetochores (Rattus norvegicus)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Rattus norvegicus)
        
        MAD2 associates with the Mad1 kinetochore complex (Rattus norvegicus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        NDC80 complex [cytosol] (Rattus norvegicus)
        
        Spc24 [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        NDC80 complex [cytosol] (Rattus norvegicus)
        
        Spc24 [cytosol] (Rattus norvegicus)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Rattus norvegicus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        NDC80 complex [cytosol] (Rattus norvegicus)
        
        Spc24 [cytosol] (Rattus norvegicus)
        
        Mad1 binds kinetochore (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        NDC80 complex [cytosol] (Rattus norvegicus)
        
        Spc24 [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        NDC80 complex [cytosol] (Rattus norvegicus)
        
        Spc24 [cytosol] (Rattus norvegicus)
        
        Release of activated MAD2 from kinetochores (Rattus norvegicus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        NDC80 complex [cytosol] (Rattus norvegicus)
        
        Spc24 [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        NDC80 complex [cytosol] (Rattus norvegicus)
        
        Spc24 [cytosol] (Rattus norvegicus)
- Cell Cycle, Mitotic (Rattus norvegicus)
  - M Phase (Rattus norvegicus)
    - Mitotic Metaphase and Anaphase (Rattus norvegicus)
      - Mitotic Anaphase (Rattus norvegicus)
        
        Separation of Sister Chromatids (Rattus norvegicus)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Rattus norvegicus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        NDC80 complex [cytosol] (Rattus norvegicus)
        
        Spc24 [cytosol] (Rattus norvegicus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        NDC80 complex [cytosol] (Rattus norvegicus)
        
        Spc24 [cytosol] (Rattus norvegicus)
        
        Separation of sister chromatids (Rattus norvegicus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        NDC80 complex [cytosol] (Rattus norvegicus)
        
        Spc24 [cytosol] (Rattus norvegicus)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        NDC80 complex [cytosol] (Rattus norvegicus)
        
        Spc24 [cytosol] (Rattus norvegicus)
    - Mitotic Prometaphase (Rattus norvegicus)
      - EML4 and NUDC in mitotic spindle formation (Rattus norvegicus)
        
        EML4 recruits NUDC to mitotic spindle (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        NDC80 complex [cytosol] (Rattus norvegicus)
        
        Spc24 [cytosol] (Rattus norvegicus)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        NDC80 complex [cytosol] (Rattus norvegicus)
        
        Spc24 [cytosol] (Rattus norvegicus)
      - Kinetochore capture of astral microtubules (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        NDC80 complex [cytosol] (Rattus norvegicus)
        
        Spc24 [cytosol] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        NDC80 complex [cytosol] (Rattus norvegicus)
        
        Spc24 [cytosol] (Rattus norvegicus)
      - Resolution of Sister Chromatid Cohesion (Rattus norvegicus)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        NDC80 complex [cytosol] (Rattus norvegicus)
        
        Spc24 [cytosol] (Rattus norvegicus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        NDC80 complex [cytosol] (Rattus norvegicus)
        
        Spc24 [cytosol] (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        NDC80 complex [cytosol] (Rattus norvegicus)
        
        Spc24 [cytosol] (Rattus norvegicus)
        
        Kinetochore assembly (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        NDC80 complex [cytosol] (Rattus norvegicus)
        
        Spc24 [cytosol] (Rattus norvegicus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        NDC80 complex [cytosol] (Rattus norvegicus)
        
        Spc24 [cytosol] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        NDC80 complex [cytosol] (Rattus norvegicus)
        
        Spc24 [cytosol] (Rattus norvegicus)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Rattus norvegicus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        NDC80 complex [cytosol] (Rattus norvegicus)
        
        Spc24 [cytosol] (Rattus norvegicus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        NDC80 complex [cytosol] (Rattus norvegicus)
        
        Spc24 [cytosol] (Rattus norvegicus)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        NDC80 complex [cytosol] (Rattus norvegicus)
        
        Spc24 [cytosol] (Rattus norvegicus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        NDC80 complex [cytosol] (Rattus norvegicus)
        
        Spc24 [cytosol] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Rattus norvegicus)
  - Signaling by Rho GTPases (Rattus norvegicus)
    - RHO GTPase Effectors (Rattus norvegicus)
      - RHO GTPases Activate Formins (Rattus norvegicus)
        
        AURKB phosphorylates DIAPH2-2 at kinetochores (Rattus norvegicus)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        NDC80 complex [cytosol] (Rattus norvegicus)
        
        Spc24 [cytosol] (Rattus norvegicus)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        NDC80 complex [cytosol] (Rattus norvegicus)
        
        Spc24 [cytosol] (Rattus norvegicus)
        
        CDC42:GTP recruits DIAPH2-2 to kinetochores (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        NDC80 complex [cytosol] (Rattus norvegicus)
        
        Spc24 [cytosol] (Rattus norvegicus)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        NDC80 complex [cytosol] (Rattus norvegicus)
        
        Spc24 [cytosol] (Rattus norvegicus)
        
        Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        NDC80 complex [cytosol] (Rattus norvegicus)
        
        Spc24 [cytosol] (Rattus norvegicus)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        NDC80 complex [cytosol] (Rattus norvegicus)
        
        Spc24 [cytosol] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        NDC80 complex [cytosol] (Rattus norvegicus)
        
        Spc24 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:D4A1C5

Gene Names

Spc24

Reference Genes

ENSEMBL:ENSRNOG00000029862

ENSEMBL:ENSRNOG00000029862.6 Spc24

Other Identifiers

10915578

1373026_at

17850348

363028

5617787

5905357

6078560

6245580

6289213

6598836

A_44_P1059985

A_64_P129413

A_64_P268234

GE1170204

GE15996

GO:0000776

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0007059

GO:0008608

GO:0031262

GO:0043226

ILMN_1364291

PH_rn_0021546

rc_AI030023_at

Participates

as a component of

NDC80 complex [cytosol] (Rattus norvegicus)

Inferred From

SPC24 [cytosol] (Homo sapiens)

Cross References

Ensembl

ENSRNOG00000029862, ENSRNOP00000045819, ENSRNOT00000045384

RGD

1307631

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