Reactome | Zwint [cytosol]

Zwint [cytosol]

Stable Identifier

R-RNO-376254

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

ZWINT, Q8VIL3

Locations in the PathwayBrowser

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Cell Cycle (Rattus norvegicus)

- Cell Cycle Checkpoints (Rattus norvegicus)
  - Mitotic Spindle Checkpoint (Rattus norvegicus)
    - Amplification of signal from the kinetochores (Rattus norvegicus)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Rattus norvegicus)
        
        MAD2 associates with the Mad1 kinetochore complex (Rattus norvegicus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        KNL1:ZWINT [cytosol] (Rattus norvegicus)
        
        Zwint [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        KNL1:ZWINT [cytosol] (Rattus norvegicus)
        
        Zwint [cytosol] (Rattus norvegicus)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Rattus norvegicus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        KNL1:ZWINT [cytosol] (Rattus norvegicus)
        
        Zwint [cytosol] (Rattus norvegicus)
        
        Mad1 binds kinetochore (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        KNL1:ZWINT [cytosol] (Rattus norvegicus)
        
        Zwint [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        KNL1:ZWINT [cytosol] (Rattus norvegicus)
        
        Zwint [cytosol] (Rattus norvegicus)
        
        Release of activated MAD2 from kinetochores (Rattus norvegicus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        KNL1:ZWINT [cytosol] (Rattus norvegicus)
        
        Zwint [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        KNL1:ZWINT [cytosol] (Rattus norvegicus)
        
        Zwint [cytosol] (Rattus norvegicus)
- Cell Cycle, Mitotic (Rattus norvegicus)
  - M Phase (Rattus norvegicus)
    - Mitotic Metaphase and Anaphase (Rattus norvegicus)
      - Mitotic Anaphase (Rattus norvegicus)
        
        Separation of Sister Chromatids (Rattus norvegicus)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Rattus norvegicus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        KNL1:ZWINT [cytosol] (Rattus norvegicus)
        
        Zwint [cytosol] (Rattus norvegicus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        KNL1:ZWINT [cytosol] (Rattus norvegicus)
        
        Zwint [cytosol] (Rattus norvegicus)
        
        Separation of sister chromatids (Rattus norvegicus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        KNL1:ZWINT [cytosol] (Rattus norvegicus)
        
        Zwint [cytosol] (Rattus norvegicus)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        KNL1:ZWINT [cytosol] (Rattus norvegicus)
        
        Zwint [cytosol] (Rattus norvegicus)
    - Mitotic Prometaphase (Rattus norvegicus)
      - EML4 and NUDC in mitotic spindle formation (Rattus norvegicus)
        
        EML4 recruits NUDC to mitotic spindle (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        KNL1:ZWINT [cytosol] (Rattus norvegicus)
        
        Zwint [cytosol] (Rattus norvegicus)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        KNL1:ZWINT [cytosol] (Rattus norvegicus)
        
        Zwint [cytosol] (Rattus norvegicus)
      - Kinetochore capture of astral microtubules (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        KNL1:ZWINT [cytosol] (Rattus norvegicus)
        
        Zwint [cytosol] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        KNL1:ZWINT [cytosol] (Rattus norvegicus)
        
        Zwint [cytosol] (Rattus norvegicus)
      - Resolution of Sister Chromatid Cohesion (Rattus norvegicus)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        KNL1:ZWINT [cytosol] (Rattus norvegicus)
        
        Zwint [cytosol] (Rattus norvegicus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        KNL1:ZWINT [cytosol] (Rattus norvegicus)
        
        Zwint [cytosol] (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        KNL1:ZWINT [cytosol] (Rattus norvegicus)
        
        Zwint [cytosol] (Rattus norvegicus)
        
        Kinetochore assembly (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        KNL1:ZWINT [cytosol] (Rattus norvegicus)
        
        Zwint [cytosol] (Rattus norvegicus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        KNL1:ZWINT [cytosol] (Rattus norvegicus)
        
        Zwint [cytosol] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        KNL1:ZWINT [cytosol] (Rattus norvegicus)
        
        Zwint [cytosol] (Rattus norvegicus)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Rattus norvegicus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        KNL1:ZWINT [cytosol] (Rattus norvegicus)
        
        Zwint [cytosol] (Rattus norvegicus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        KNL1:ZWINT [cytosol] (Rattus norvegicus)
        
        Zwint [cytosol] (Rattus norvegicus)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        KNL1:ZWINT [cytosol] (Rattus norvegicus)
        
        Zwint [cytosol] (Rattus norvegicus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        KNL1:ZWINT [cytosol] (Rattus norvegicus)
        
        Zwint [cytosol] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Rattus norvegicus)
  - Signaling by Rho GTPases (Rattus norvegicus)
    - RHO GTPase Effectors (Rattus norvegicus)
      - RHO GTPases Activate Formins (Rattus norvegicus)
        
        AURKB phosphorylates DIAPH2-2 at kinetochores (Rattus norvegicus)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        KNL1:ZWINT [cytosol] (Rattus norvegicus)
        
        Zwint [cytosol] (Rattus norvegicus)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        KNL1:ZWINT [cytosol] (Rattus norvegicus)
        
        Zwint [cytosol] (Rattus norvegicus)
        
        CDC42:GTP recruits DIAPH2-2 to kinetochores (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        KNL1:ZWINT [cytosol] (Rattus norvegicus)
        
        Zwint [cytosol] (Rattus norvegicus)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        KNL1:ZWINT [cytosol] (Rattus norvegicus)
        
        Zwint [cytosol] (Rattus norvegicus)
        
        Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        KNL1:ZWINT [cytosol] (Rattus norvegicus)
        
        Zwint [cytosol] (Rattus norvegicus)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        KNL1:ZWINT [cytosol] (Rattus norvegicus)
        
        Zwint [cytosol] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        KNL1:ZWINT [cytosol] (Rattus norvegicus)
        
        Zwint [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q8VIL3

Gene Names

Zwint

Reference Genes

BioGPS Gene:257644 Zwint

ENSEMBL:ENSRNOG00000048682

ENSEMBL:ENSRNOG00055022622

ENSEMBL:ENSRNOG00060028638

ENSEMBL:ENSRNOG00065023618

KEGG:rno:257644 Zwint

Monarch:257644 Zwint

NCBI Gene:257644 Zwint

UCSC:Q8VIL3 Zwint

Reference Transcript

Other Identifiers

10940592

1370803_at

17882625

17882626

257644

5973847

5997900

6212258

6213412

A_42_P668042

GE14765

GO:0000776

GO:0007093

GO:0031619

GO:0043226

GO:1905325

PH_rn_0015455

rc_AA819709_at

Participates

as a component of

KNL1:ZWINT [cytosol] (Rattus norvegicus)

Inferred From

ZWINT [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_038954393.1, XP_063135057.1, NP_671479.1

ENSEMBL

ENSRNOP00000067414, ENSRNOT00000074404, ENSRNOG00000048682

PRO

Q8VIL3

RGD

628671

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