Reactome | Ywhag [cytosol]

Ywhag [cytosol]

Stable Identifier

R-RNO-380312

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

YWHAG, P61983

Locations in the PathwayBrowser

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Organelle biogenesis and maintenance (Rattus norvegicus)

- Cilium Assembly (Rattus norvegicus)
  - Anchoring of the basal body to the plasma membrane (Rattus norvegicus)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Rattus norvegicus)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Rattus norvegicus)
        
        mother centriole:C2CD3 [cytosol] (Rattus norvegicus)
        
        mother centriole [cytosol] (Rattus norvegicus)
        
        Ywhag [cytosol] (Rattus norvegicus)
      - mother centriole:C2CD3 [cytosol] (Rattus norvegicus)
        
        mother centriole [cytosol] (Rattus norvegicus)
        
        Ywhag [cytosol] (Rattus norvegicus)
    - C2CD3 binds the mother centriole (Rattus norvegicus)
      - mother centriole [cytosol] (Rattus norvegicus)
        
        Ywhag [cytosol] (Rattus norvegicus)
      - mother centriole:C2CD3 [cytosol] (Rattus norvegicus)
        
        mother centriole [cytosol] (Rattus norvegicus)
        
        Ywhag [cytosol] (Rattus norvegicus)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Rattus norvegicus)
      - basal body:transition zone proteins [cytosol] (Rattus norvegicus)
        
        basal body [cytosol] (Rattus norvegicus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Rattus norvegicus)
        
        Ywhag [cytosol] (Rattus norvegicus)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Rattus norvegicus)
        
        basal body:transition zone proteins [cytosol] (Rattus norvegicus)
        
        basal body [cytosol] (Rattus norvegicus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Rattus norvegicus)
        
        Ywhag [cytosol] (Rattus norvegicus)
    - CP110 and CEP97 dissociate from the centriole (Rattus norvegicus)
      - basal body [cytosol] (Rattus norvegicus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Rattus norvegicus)
        
        Ywhag [cytosol] (Rattus norvegicus)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Rattus norvegicus)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Rattus norvegicus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Rattus norvegicus)
        
        mother centriole:C2CD3 [cytosol] (Rattus norvegicus)
        
        mother centriole [cytosol] (Rattus norvegicus)
        
        Ywhag [cytosol] (Rattus norvegicus)
    - MARK4 binds ODF2 in the centriole (Rattus norvegicus)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Rattus norvegicus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Rattus norvegicus)
        
        mother centriole:C2CD3 [cytosol] (Rattus norvegicus)
        
        mother centriole [cytosol] (Rattus norvegicus)
        
        Ywhag [cytosol] (Rattus norvegicus)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Rattus norvegicus)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Rattus norvegicus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Rattus norvegicus)
        
        mother centriole:C2CD3 [cytosol] (Rattus norvegicus)
        
        mother centriole [cytosol] (Rattus norvegicus)
        
        Ywhag [cytosol] (Rattus norvegicus)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Rattus norvegicus)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Rattus norvegicus)
        
        basal body:transition zone proteins [cytosol] (Rattus norvegicus)
        
        basal body [cytosol] (Rattus norvegicus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Rattus norvegicus)
        
        Ywhag [cytosol] (Rattus norvegicus)
    - Recruitment of transition zone proteins (Rattus norvegicus)
      - basal body [cytosol] (Rattus norvegicus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Rattus norvegicus)
        
        Ywhag [cytosol] (Rattus norvegicus)
      - basal body:transition zone proteins [cytosol] (Rattus norvegicus)
        
        basal body [cytosol] (Rattus norvegicus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Rattus norvegicus)
        
        Ywhag [cytosol] (Rattus norvegicus)
    - The distal appendage proteins recruit TTBK2 (Rattus norvegicus)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Rattus norvegicus)
        
        mother centriole:C2CD3 [cytosol] (Rattus norvegicus)
        
        mother centriole [cytosol] (Rattus norvegicus)
        
        Ywhag [cytosol] (Rattus norvegicus)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Rattus norvegicus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Rattus norvegicus)
        
        mother centriole:C2CD3 [cytosol] (Rattus norvegicus)
        
        mother centriole [cytosol] (Rattus norvegicus)
        
        Ywhag [cytosol] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Rattus norvegicus)
  - Signaling by Rho GTPases (Rattus norvegicus)
    - RHO GTPase Effectors (Rattus norvegicus)
      - RHO GTPases activate PKNs (Rattus norvegicus)
        
        Association of p-S216-CDC25C with 14-3-3 proteins (Rattus norvegicus)
        
        14-3-3 dimer [cytosol] (Rattus norvegicus)
        
        YWHAG dimer [cytosol] (Rattus norvegicus)
        
        Ywhag [cytosol] (Rattus norvegicus)
        
        p-S216-CDC25C:14-3-3 protein complex [cytosol] (Rattus norvegicus)
        
        14-3-3 dimer [cytosol] (Rattus norvegicus)
        
        YWHAG dimer [cytosol] (Rattus norvegicus)
        
        Ywhag [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P61983

Gene Names

Ywhag

Reference Genes

BioGPS Gene:56010 Ywhag

ENSEMBL:ENSRNOG00000001436

ENSEMBL:ENSRNOG00000001436.6 Ywhag

ENSEMBL:ENSRNOG00055000321

ENSEMBL:ENSRNOG00060010383

ENSEMBL:ENSRNOG00065001781

KEGG Gene (Rattus norvegicus):56010 Ywhag

Monarch:56010 Ywhag

NCBI Gene:56010 Ywhag

UCSC:P61983 Ywhag

Reference Transcript

Other Identifiers

10757599

1386866_at

17672892

17672897

56010

6004539

6345392

6364731

6467990

6643213

A_44_P325791

GE20694

GE21579

GO:0005080

GO:0005159

GO:0006605

GO:0006886

GO:0019904

GO:0023052

GO:0030154

GO:0042149

GO:0042802

GO:0045664

GO:0048167

GO:0048856

GO:0050815

GO:0140311

GO:0140313

GO:1904262

PH_rn_0003378

S55305_s_at

Participates

as a component of

Inferred From

YWHAG [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_062249.1, XP_006249246.2

Ensembl

ENSRNOT00000001954, ENSRNOG00000001436, ENSRNOP00000001954

PRO

P61983

RGD

62002

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.65	6

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