Reactome | Fbxw10 [cytosol]

Fbxw10 [cytosol]

Stable Identifier

R-RNO-391307

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

FBXW10, D4A8I5

Locations in the PathwayBrowser

Expand all

Immune System (Rattus norvegicus)

- Adaptive Immune System (Rattus norvegicus)
  - Class I MHC mediated antigen processing & presentation (Rattus norvegicus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Rattus norvegicus)
      - Interaction of E3 with substrate and E2-Ub complex (Rattus norvegicus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxw10 [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxw10 [cytosol] (Rattus norvegicus)
      - Polyubiquitination of substrate (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxw10 [cytosol] (Rattus norvegicus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxw10 [cytosol] (Rattus norvegicus)
        
        E3:Ub:substrate [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxw10 [cytosol] (Rattus norvegicus)
      - Release of E3 from polyubiquitinated substrate (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxw10 [cytosol] (Rattus norvegicus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxw10 [cytosol] (Rattus norvegicus)
      - Transfer of Ub from E2 to substrate and release of E2 (Rattus norvegicus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxw10 [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxw10 [cytosol] (Rattus norvegicus)
        
        E3:Ub:substrate [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxw10 [cytosol] (Rattus norvegicus)

Metabolism of proteins (Rattus norvegicus)

- Post-translational protein modification (Rattus norvegicus)
  - Neddylation (Rattus norvegicus)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxw10 [cytosol] (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxw10 [cytosol] (Rattus norvegicus)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxw10 [cytosol] (Rattus norvegicus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
        
        CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxw10 [cytosol] (Rattus norvegicus)
      - CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxw10 [cytosol] (Rattus norvegicus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
        
        CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxw10 [cytosol] (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxw10 [cytosol] (Rattus norvegicus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxw10 [cytosol] (Rattus norvegicus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxw10 [cytosol] (Rattus norvegicus)
    - MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxw10 [cytosol] (Rattus norvegicus)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxw10 [cytosol] (Rattus norvegicus)
    - NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxw10 [cytosol] (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxw10 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:D4A8I5

Gene Names

Fbxw10

Reference Genes

ENSEMBL:ENSRNOG00000003287

ENSEMBL:ENSRNOG00000003287.7 Fbxw10

Other Identifiers

10734356

17646737

303214

303215

5657263

5721496

5789829

5840256

5919638

6166878

6222255

6412295

6421864

6492430

6503580

6589035

6597499

6745377

A_44_P187814

GO:0005515

ILMN_1365587

PH_rn_0022131

PH_rn_0024093

Participates

as a member of

F-box protein [cytosol] (Rattus norvegicus)

Inferred From

FBXW10 [cytosol] (Homo sapiens)

Cross References

Ensembl

ENSRNOT00000004390, ENSRNOP00000004390, ENSRNOG00000003287

RGD

1563889

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