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Cul2 [cytosol]
Stable Identifier
R-RNO-416982
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
CUL2, A0A8I6G8I6
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Cellular response to hypoxia (Rattus norvegicus)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Rattus norvegicus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Rattus norvegicus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
Cul2 [cytosol] (Rattus norvegicus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Rattus norvegicus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
Cul2 [cytosol] (Rattus norvegicus)
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Rattus norvegicus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Rattus norvegicus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
Cul2 [cytosol] (Rattus norvegicus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Rattus norvegicus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
Cul2 [cytosol] (Rattus norvegicus)
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Rattus norvegicus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
Cul2 [cytosol] (Rattus norvegicus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Rattus norvegicus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
Cul2 [cytosol] (Rattus norvegicus)
Proteasome proteolyzes ub-HIF-alpha (Rattus norvegicus)
VBC complex (with or without LIMD1) [cytosol] (Rattus norvegicus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
Cul2 [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
Cul2 [cytosol] (Rattus norvegicus)
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Rattus norvegicus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
Cul2 [cytosol] (Rattus norvegicus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Rattus norvegicus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
Cul2 [cytosol] (Rattus norvegicus)
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Rattus norvegicus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
Cul2 [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Class I MHC mediated antigen processing & presentation (Rattus norvegicus)
Antigen processing: Ubiquitination & Proteasome degradation (Rattus norvegicus)
Interaction of E3 with substrate and E2-Ub complex (Rattus norvegicus)
Ag-substrate:E3:E2:Ub [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
Cul2 [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
Cul2 [cytosol] (Rattus norvegicus)
Polyubiquitination of substrate (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
Cul2 [cytosol] (Rattus norvegicus)
E3:K48-polyubiquitinated substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
Cul2 [cytosol] (Rattus norvegicus)
E3:Ub:substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
Cul2 [cytosol] (Rattus norvegicus)
Release of E3 from polyubiquitinated substrate (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
Cul2 [cytosol] (Rattus norvegicus)
E3:K48-polyubiquitinated substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
Cul2 [cytosol] (Rattus norvegicus)
Transfer of Ub from E2 to substrate and release of E2 (Rattus norvegicus)
Ag-substrate:E3:E2:Ub [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
Cul2 [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
Cul2 [cytosol] (Rattus norvegicus)
E3:Ub:substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
Cul2 [cytosol] (Rattus norvegicus)
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
Neddylation (Rattus norvegicus)
AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Rattus norvegicus)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
Cul2 [cytosol] (Rattus norvegicus)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Rattus norvegicus)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
Cul2 [cytosol] (Rattus norvegicus)
CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
Cul2 [cytosol] (Rattus norvegicus)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
Cul2 [cytosol] (Rattus norvegicus)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
Cul2 [cytosol] (Rattus norvegicus)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
Cul2 [cytosol] (Rattus norvegicus)
NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Rattus norvegicus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
Cul2 [cytosol] (Rattus norvegicus)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
Cul2 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:A0A8I6G8I6
Gene Names
Cul2
Reference Genes
BioGPS Gene:361258 Cul2
ENSEMBL:ENSRNOG00000015292
ENSEMBL:ENSRNOG00000015292.8 Cul2
Monarch:361258 Cul2
NCBI Gene:361258 Cul2
Reference Transcript
RefSeq:XM_006254072.3 Cul2
RefSeq:XM_006254073.3 Cul2
RefSeq:XM_017600628.1 Cul2
Other Identifiers
10798856
1383106_at
17719945
361258
5670700
5676510
5727981
5792588
5877301
5892084
5898424
5953700
5985546
6016246
6054889
6069077
6108918
6206266
6363465
6382356
6446140
6462512
6487128
6516622
6600282
6660047
GE1223815
GO:0005634
GO:0005654
GO:0005730
GO:0006511
GO:0030163
GO:0031461
GO:0031462
GO:0031625
GO:0043226
GO:0140627
GO:0160072
rc_AA875598_at
Participates
as a component of
CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
Other forms of this molecule
Cul2 [cytosol]
Cul2 [nucleoplasm]
Inferred From
CUL2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_006254135.1
,
XP_006254134.1
,
XP_017456117.1
Ensembl
ENSRNOP00000081844
,
ENSRNOG00000015292
,
ENSRNOT00000108140
RGD
1310644
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