Reactome | Faap24 [nucleoplasm]

Faap24 [nucleoplasm]

Stable Identifier

R-RNO-419533

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

nucleoplasm

Synonyms

FAAP24, D3ZE71

Locations in the PathwayBrowser

Expand all

DNA Repair (Rattus norvegicus)

- Fanconi Anemia Pathway (Rattus norvegicus)
  - ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Rattus norvegicus)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Rattus norvegicus)
      - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        FANCM:FAAP24 [nucleoplasm] (Rattus norvegicus)
        
        Faap24 [nucleoplasm] (Rattus norvegicus)
    - p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        p-S1045-FANCM:FAAP24 [nucleoplasm] (Rattus norvegicus)
        
        Faap24 [nucleoplasm] (Rattus norvegicus)
  - DNA nucleases bind monoubiquitinated ID2 complex (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        p-S1045-FANCM:FAAP24 [nucleoplasm] (Rattus norvegicus)
        
        Faap24 [nucleoplasm] (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Rattus norvegicus)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        p-S1045-FANCM:FAAP24 [nucleoplasm] (Rattus norvegicus)
        
        Faap24 [nucleoplasm] (Rattus norvegicus)
  - DNA nucleases unhook the interstrand crosslink (ICL) (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Rattus norvegicus)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        p-S1045-FANCM:FAAP24 [nucleoplasm] (Rattus norvegicus)
        
        Faap24 [nucleoplasm] (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - FA core complex [nucleoplasm] (Rattus norvegicus)
        
        Faap24 [nucleoplasm] (Rattus norvegicus)
  - FANCD2 deubiquitination by USP1:WDR48 (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        p-S1045-FANCM:FAAP24 [nucleoplasm] (Rattus norvegicus)
        
        Faap24 [nucleoplasm] (Rattus norvegicus)
    - p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        p-S1045-FANCM:FAAP24 [nucleoplasm] (Rattus norvegicus)
        
        Faap24 [nucleoplasm] (Rattus norvegicus)
  - FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Rattus norvegicus)
    - FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        FANCM:FAAP24 [nucleoplasm] (Rattus norvegicus)
        
        Faap24 [nucleoplasm] (Rattus norvegicus)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        FANCM:FAAP24 [nucleoplasm] (Rattus norvegicus)
        
        Faap24 [nucleoplasm] (Rattus norvegicus)
  - FANCM binds FAAP24 (Rattus norvegicus)
    - FANCM:FAAP24 [nucleoplasm] (Rattus norvegicus)
      - Faap24 [nucleoplasm] (Rattus norvegicus)
    - Faap24 [nucleoplasm] (Rattus norvegicus)
  - Monoubiquitination of FANCD2:FANCI (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        p-S1045-FANCM:FAAP24 [nucleoplasm] (Rattus norvegicus)
        
        Faap24 [nucleoplasm] (Rattus norvegicus)
    - p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        p-S1045-FANCM:FAAP24 [nucleoplasm] (Rattus norvegicus)
        
        Faap24 [nucleoplasm] (Rattus norvegicus)
  - POLN binds ICL-DNA (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - FA core complex [nucleoplasm] (Rattus norvegicus)
        
        Faap24 [nucleoplasm] (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Rattus norvegicus)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA core complex [nucleoplasm] (Rattus norvegicus)
        
        Faap24 [nucleoplasm] (Rattus norvegicus)
  - The complex of ATR and ATRIP is recruited to ICL-DNA (Rattus norvegicus)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        FANCM:FAAP24 [nucleoplasm] (Rattus norvegicus)
        
        Faap24 [nucleoplasm] (Rattus norvegicus)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Rattus norvegicus)
      - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        FANCM:FAAP24 [nucleoplasm] (Rattus norvegicus)
        
        Faap24 [nucleoplasm] (Rattus norvegicus)
  - Translesion synthesis across unhooked ICL by POLN (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Rattus norvegicus)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA core complex [nucleoplasm] (Rattus norvegicus)
        
        Faap24 [nucleoplasm] (Rattus norvegicus)
    - p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
      - p-S1045-FANCM:FAAP24 [nucleoplasm] (Rattus norvegicus)
        
        Faap24 [nucleoplasm] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:D3ZE71

Gene Names

Faap24

Reference Genes

BioGPS Gene:502320 Faap24

ENSEMBL:ENSRNOG00000022393

ENSEMBL:ENSRNOG00000022393.4 Faap24

KEGG Gene (Rattus norvegicus):502320 Faap24

Monarch:502320 Faap24

NCBI Gene:502320 Faap24

UCSC:D3ZE71 Faap24

Reference Transcript

Other Identifiers

10721094

1379319_at

17632056

502320

5849980

6033402

6060282

6078892

6147062

6273675

6466588

6681322

A_44_P576764

A_64_P030122

GE13792

GO:0000785

GO:0003682

GO:0005634

GO:0005654

GO:0005694

GO:0006281

GO:0036297

GO:0043226

GO:0043231

GO:0043240

GO:0071821

PH_rn_0009936

rc_AA901179_at

rc_AI044740_at

Participates

as a component of

as an input of

FANCM binds FAAP24 (Rattus norvegicus)

Other forms of this molecule

Faap24 [cytosol]

Inferred From

FAAP24 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001102805.1, XP_006228958.1

Ensembl

ENSRNOP00000031862, ENSRNOT00000033396, ENSRNOG00000022393

RGD

1564719

Cite Us!