Reactome | GRIN2B [plasma membrane]

GRIN2B [plasma membrane]

Stable Identifier

R-RNO-419558

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

Q00960

Locations in the PathwayBrowser

Expand all

Neuronal System (Rattus norvegicus)

- Protein-protein interactions at synapses (Rattus norvegicus)
  - Synaptic adhesion-like molecules (Rattus norvegicus)
    - PSD-95 binds NMDA receptor (Rattus norvegicus)
      - NMDA receptor complex [plasma membrane] (Rattus norvegicus)
        
        NMDA receptor [plasma membrane] (Rattus norvegicus)
        
        NR2 subunits [plasma membrane] (Rattus norvegicus)
        
        GRIN2B [plasma membrane] (Rattus norvegicus)
      - NMDAR:PSD-95 [plasma membrane] (Rattus norvegicus)
        
        NMDA receptor complex [plasma membrane] (Rattus norvegicus)
        
        NMDA receptor [plasma membrane] (Rattus norvegicus)
        
        NR2 subunits [plasma membrane] (Rattus norvegicus)
        
        GRIN2B [plasma membrane] (Rattus norvegicus)
    - SALM1 binds NMDA receptor (Rattus norvegicus)
      - NMDAR:PSD-95 [plasma membrane] (Rattus norvegicus)
        
        NMDA receptor complex [plasma membrane] (Rattus norvegicus)
        
        NMDA receptor [plasma membrane] (Rattus norvegicus)
        
        NR2 subunits [plasma membrane] (Rattus norvegicus)
        
        GRIN2B [plasma membrane] (Rattus norvegicus)
      - SALM1:NMDAR:PSD-95 [plasma membrane] (Rattus norvegicus)
        
        NMDAR:PSD-95 [plasma membrane] (Rattus norvegicus)
        
        NMDA receptor complex [plasma membrane] (Rattus norvegicus)
        
        NMDA receptor [plasma membrane] (Rattus norvegicus)
        
        NR2 subunits [plasma membrane] (Rattus norvegicus)
        
        GRIN2B [plasma membrane] (Rattus norvegicus)
    - SALM2 associate with AMPA and NMDA receptors (Rattus norvegicus)
      - AMPA, NMDA receptors [plasma membrane] (Rattus norvegicus)
        
        NMDA receptor complex [plasma membrane] (Rattus norvegicus)
        
        NMDA receptor [plasma membrane] (Rattus norvegicus)
        
        NR2 subunits [plasma membrane] (Rattus norvegicus)
        
        GRIN2B [plasma membrane] (Rattus norvegicus)
      - SALM2:AMPA, NMDA receptors [plasma membrane] (Rattus norvegicus)
        
        AMPA, NMDA receptors [plasma membrane] (Rattus norvegicus)
        
        NMDA receptor complex [plasma membrane] (Rattus norvegicus)
        
        NMDA receptor [plasma membrane] (Rattus norvegicus)
        
        NR2 subunits [plasma membrane] (Rattus norvegicus)
        
        GRIN2B [plasma membrane] (Rattus norvegicus)
- Transmission across Chemical Synapses (Rattus norvegicus)
  - Neurotransmitter receptors and postsynaptic signal transmission (Rattus norvegicus)
    - Activation of NMDA receptors and postsynaptic events (Rattus norvegicus)
      - Assembly and cell surface presentation of NMDA receptors (Rattus norvegicus)
        
        GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Rattus norvegicus)
        
        GRIN1:GRIN2A,C,D di-heteromers,GRIN1:GRIN2 tri-heteromers [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B:GRIN2D tri-heterotetramer [plasma membrane] (Rattus norvegicus)
        
        GRIN2B [plasma membrane] (Rattus norvegicus)
      - Unblocking of NMDA receptors, glutamate binding and activation (Rattus norvegicus)
        
        Ca2+ influx into the post-synaptic cell (Rattus norvegicus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2 NMDA receptors [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2A,C,D di-heteromers,GRIN1:GRIN2 tri-heteromers [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B:GRIN2D tri-heterotetramer [plasma membrane] (Rattus norvegicus)
        
        GRIN2B [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B di-heterotetramer [plasma membrane] (Rattus norvegicus)
        
        GRIN2B [plasma membrane] (Rattus norvegicus)
        
        Membrane depolarization upon activation of Ca impermeable AMPA receptors (Rattus norvegicus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Rattus norvegicus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B NMDA receptors [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B di-heterotetramer [plasma membrane] (Rattus norvegicus)
        
        GRIN2B [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B:GRIN2D tri-heterotetramer [plasma membrane] (Rattus norvegicus)
        
        GRIN2B [plasma membrane] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- MAPK family signaling cascades (Rattus norvegicus)
  - MAPK1/MAPK3 signaling (Rattus norvegicus)
    - RAF/MAP kinase cascade (Rattus norvegicus)
      - RAS GEFs promote RAS nucleotide exchange (Rattus norvegicus)
        
        RAS GEFs [plasma membrane] (Rattus norvegicus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Rattus norvegicus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B NMDA receptors [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B di-heterotetramer [plasma membrane] (Rattus norvegicus)
        
        GRIN2B [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B:GRIN2D tri-heterotetramer [plasma membrane] (Rattus norvegicus)
        
        GRIN2B [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q00960 Grin2b

Gene Names

Grin2b

Chain

signal peptide:1-26, chain:27-1482

Reference Genes

BioGPS Gene:24410 Grin2b

KEGG Gene (Rattus norvegicus):24410 Grin2b

Monarch:24410 Grin2b

NCBI Gene:24410 Grin2b

UCSC:Q00960 Grin2b

Reference Transcript

RefSeq:NM_012574.1 Grin2b

Participates

as a member of

NR2 subunits [plasma membrane] (Rattus norvegicus)

as a component of

Other forms of this molecule

phospho-p-Y1252,Y1336,Y1474-GRIN2B [plasma membrane]

p-Y1472-Grin2b [plasma membrane]

p-Y-Grin2b [plasma membrane]

Grin2b [endoplasmic reticulum membrane]

GRIN2B [endoplasmic reticulum membrane]

Grin2b [plasma membrane]

Inferred From

GRIN2B [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_036706.1

ZINC - Investigational

NMDE2_RAT

ZINC - World Drugs

NMDE2_RAT

ZINC - Substances

NMDE2_RAT

ZINC target

Q00960

ZINC - Biogenic

NMDE2_RAT

PRO

Q00960

ZINC - Predictions - Purchasable

NMDE2_RAT

RGD

2738

PDB

5FXJ, 5FXI, 6E7R, 6WHV, 6WHW, 7TES, 7TER, 7TEQ, 6E7S, 7TET, 5FXK, 6WHX, 6E7T, 6WI0, 7TE6, 6WHY, 7TE9, 6WHS, 6E7U, 3QEM, 6WHR, 6WI1, 3QEL, 6E7V, 6CNA, 5FXG, 3JPW, 6E7X, 5B3J, 5FXH, 5TPZ, 6E7W, 6WHT, 7TEE, 4PE5, 6WHU, 7TEB, 3JPY

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31016 Dlg4	3	Dlg4 [endocytic vesicle membrane] (R-RNO-416847) Dlg4 [cytosol] (R-RNO-6794248) Dlg4 [plasma membrane] (R-RNO-9612601)	0.915	11
UniProt:P35439 Grin1	2	Grin1 [endoplasmic reticulum membrane] (R-RNO-9609841) Grin1 [plasma membrane] (R-RNO-9610826)	0.829	12
UniProt:A0A1L8F5J9-8 GRIN1			0.74	6
UniProt:Q62936	2	Dlg3 [cytosol] (R-RNO-6794232) Dlg3 [plasma membrane] (R-RNO-443609)	0.704	6
UniProt:P11798 Camk2a	6	phospho-p-T286-CAMK2A [plasma membrane] (R-MMU-432796) p-T286-Camk2a [nucleoplasm] (R-MMU-9608160) phospho-p-T286-CAMK2A [endocytic vesicle membrane] (R-MMU-416999) phospho-p-T286,T305,T306-CAMK2A [cytosol] (R-MMU-4332334) CAMK2A [cytosol] (R-MMU-4332329) phospho-p-T286-CAMK2A [cytosol] (R-MMU-445368)	0.704	4
UniProt:P11275 Camk2a	6	phospho-p-T286-CAMK2A [plasma membrane] (R-RNO-432796) phospho-p-T286-CAMK2A [nucleoplasm] (R-RNO-444797) phospho-p-T286-CAMK2A [endocytic vesicle membrane] (R-RNO-416999) phospho-p-T286,T305,T306-CAMK2A [cytosol] (R-RNO-4332334) Camk2a [cytosol] (R-RNO-9611390) p-T286-Camk2a [cytosol] (R-RNO-9618632)	0.589	2
UniProt:Q9Z252 Lin7b	1	Lin7b [plasma membrane] (R-RNO-6794272)	0.576	5
UniProt:Q63ZW7 INADL			0.508	4

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