Reactome | GRM1 [plasma membrane]

GRM1 [plasma membrane]

Stable Identifier

R-RNO-420521

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

P23385

Locations in the PathwayBrowser

Expand all

Signal Transduction (Rattus norvegicus)

- Signaling by GPCR (Rattus norvegicus)
  - GPCR downstream signalling (Rattus norvegicus)
    - G alpha (q) signalling events (Rattus norvegicus)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Rattus norvegicus)
        
        Group I Metabotropic glutamate receptors:Glu [plasma membrane] (Rattus norvegicus)
        
        GRM1,GRM5 [plasma membrane] (Rattus norvegicus)
        
        GRM1 [plasma membrane] (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Rattus norvegicus)
        
        Group I Metabotropic glutamate receptors:Glu [plasma membrane] (Rattus norvegicus)
        
        GRM1,GRM5 [plasma membrane] (Rattus norvegicus)
        
        GRM1 [plasma membrane] (Rattus norvegicus)
  - GPCR ligand binding (Rattus norvegicus)
    - Class C/3 (Metabotropic glutamate/pheromone receptors) (Rattus norvegicus)
      - Metabotropic glutamate receptors bind glutamate (Rattus norvegicus)
        
        GRM1-8 [plasma membrane] (Rattus norvegicus)
        
        GRM1,GRM5 [plasma membrane] (Rattus norvegicus)
        
        GRM1 [plasma membrane] (Rattus norvegicus)
        
        GRM1-8:L-Glu [plasma membrane] (Rattus norvegicus)
        
        GRM1-8 [plasma membrane] (Rattus norvegicus)
        
        GRM1,GRM5 [plasma membrane] (Rattus norvegicus)
        
        GRM1 [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P23385 Grm1

Gene Names

Grm1, Gprc1a, Mglur1

Chain

signal peptide:1-18, chain:19-1199

Reference Genes

BioGPS Gene:24414 Grm1

ENSEMBL:ENSRNOG00000014290.8 Grm1

ENSEMBL:ENSRNOG00055001767 Grm1

ENSEMBL:ENSRNOG00060006069 Grm1

ENSEMBL:ENSRNOG00065025066 Grm1

KEGG Gene (Rattus norvegicus):24414 Grm1

Monarch:24414 Grm1

NCBI Gene:24414 Grm1

UCSC:P23385 Grm1

Reference Transcript

Other Identifiers

10716789

1371180_a_at

1371181_x_at

1387286_at

17627225

24414

5643425

5666379

5779648

5783957

5831839

5833146

5909022

5927134

5937032

5991944

6006645

6023930

6078780

6141592

6152461

6157016

6203066

6284281

6357821

6420000

6488430

6503224

6516930

6540718

6602538

6610306

6686233

A_43_P15263

A_44_P435767

A_64_P102191

GE20271

GO:0001639

GO:0001640

GO:0004930

GO:0005515

GO:0005634

GO:0005886

GO:0007165

GO:0007186

GO:0007196

GO:0007200

GO:0007206

GO:0007216

GO:0007268

GO:0007626

GO:0008066

GO:0014048

GO:0014069

GO:0016020

GO:0019233

GO:0019722

GO:0023052

GO:0030331

GO:0030424

GO:0030425

GO:0038037

GO:0038038

GO:0042734

GO:0043005

GO:0043197

GO:0043226

GO:0043410

GO:0045211

GO:0050877

GO:0051899

GO:0051930

GO:0051932

GO:0051966

GO:0055065

GO:0055085

GO:0060078

GO:0060089

GO:0071257

GO:0098685

GO:0098712

GO:0098839

GO:0098872

GO:0098978

GO:0099530

GO:0099565

GO:0099566

GO:0099583

GO:0110165

M61099_at

PH_rn_0012293

Participates

as a member of

GRM1,GRM5 [plasma membrane] (Rattus norvegicus)

Other forms of this molecule

Grm1(410-1199) [plasma membrane]

Inferred From

GRM1 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_058707.1, NP_001107802.1

ZINC - World Drugs

GRM1_RAT

ZINC - FDA approved

GRM1_RAT

ZINC - Substances

GRM1_RAT

ZINC target

P23385

ZINC - Biogenic

GRM1_RAT

PRO

P23385

RGD

2742

PDB

1EWT, 1ISS, 1EWK, 1ISR, 1EWV

ZINC - Investigational

GRM1_RAT

ZINC - Metabolites

GRM1_RAT

Ensembl

ENSRNOP00000047790, ENSRNOG00000014290, ENSRNOT00000044325

ZINC - Predictions - Purchasable

GRM1_RAT

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63088 Ppp1cc	2	Serine/threonine protein phosphatase PP1-gamma catalytic subunit [cytosol] (R-RNO-163463) PPP1CC [cytosol] (R-RNO-163443)	0.581	15
UniProt:Q8CGU4 Agap2	1	PIKE-L_RAT [cytosol] (R-RNO-622356)	0.463	2

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