L1 binds ERM family members

Stable Identifier
R-RNO-443768
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
L1 binds ERM family members
Ezrin Radixin Moesin (ERM) are the members of the FERM domain (F for Band 4.1 protein, E for ezrin, R for radixin and M for moesin) containing proteins involved in localizing proteins to the plasma membrane. L1 is coupled to the tread milling actin cytoskeleton through interaction with ERM proteins. The motif KxxKYxV in the juxtamembrane region and the YRSLE sequence in L1CD are important for the ERM binding. This interaction provides a link between L1 and the actin cytoskeleton and plays a critical role in the traction force generation and regulation of neurite branching.
Literature References
PubMed ID Title Journal Year
12070130 Functional binding interaction identified between the axonal CAM L1 and members of the ERM family

Salton, SR, Mintz, CD, Dickson, TC, Benson, DL

J Cell Biol 2002
12900915 ERMs colocalize transiently with L1 during neocortical axon outgrowth

Salton, SR, Gripp, ML, Mintz, CD, Dickson, TC, Benson, DL

J Comp Neurol 2003
18478542 Interactions between the L1 cell adhesion molecule and ezrin support traction-force generation and can be regulated by tyrosine phosphorylation

Salton, SR, Gil, OD, Gazdoiu, M, Sakurai, T, Benson, DL, Joseph, T, Felsenfeld, DP, Whittard, JD, Waksman, A, Wu, J

J Neurosci Res 2008
Participants
Orthologous Events
Authored
Reviewed
Created
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