Activation of G(s) by the Glucagon-like peptide-1 receptor (Glp1r, rat)

Stable Identifier
R-RNO-446954
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Activation of G(s) by the Glucagon-like peptide-1 receptor (Glp1r, rat)
Binding of Glucagon-like peptide-1 to the Glucagon-like peptide-1 receptor causes the associated G(s) G-protein alpha subunit to exchange GDP for GTP, thereby activating G(s).
Literature References
PubMed ID Title Journal Year
12609761 Different role of intracellular loops of glucagon-like peptide-1 receptor in G-protein coupling

Bavec, A, Hällbrink, M, Zorko, M, Langel, U

Regul Pept 2003
11257510 Different domains in the third intracellular loop of the GLP-1 receptor are responsible for Galpha(s) and Galpha(i)/Galpha(o) activation

Hällbrink, M, Holmqvist, T, Ostenson, CG, Olsson, M, Efendic, S, Langel, U

Biochim Biophys Acta 2001
10067836 Pancreatic glucagon-like peptide-1 receptor couples to multiple G proteins and activates mitogen-activated protein kinase pathways in Chinese hamster ovary cells

Levine, MA, Rodgers, BD, Schwindinger, W, Yang, H, Kole, S, Bernier, M, Montrose-Rafizadeh, C, Garant, MJ, Avdonin, P

Endocrinology 1999
Participants
Input
Output
Orthologous Events
GLP1R:GLP1 activates G(s) (Homo sapiens)
Authored
May, B  (2009-11-19)
Reviewed
May, B  (2009-11-19)
Created
May, B  (2009-11-19)
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