cAMP Induces dissociation of active protein kinase A subunits from the PKA:Akap150:Iqgap1 complex

Stable Identifier
R-RNO-446974
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
General
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PNG
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cAMP Induces dissociation of active protein kinase A subunits from the PKA:Akap150:Iqgap1 complex
The regulatory subunits of protein kinase A bind cAMP which causes the catalytic subunits of protein kinase A to dissociate and become active. The regulatory subunits remain tethered at the plasma membrane by interaction with Akap5/Akap150 and Iqgap1.
Literature References
PubMed ID Title Journal Year
11181538 Targeted protein kinase A and PP-2B regulate insulin secretion through reversible phosphorylation

Lester, LB, Scott, JD, Nauert, JB, Faux, MC

Endocrinology 2001
12938160 Identification of an IQGAP1/AKAP79 complex in beta-cells

Lester, LB, Rigas, JD, Nauert, JB

J Cell Biochem 2003
19073898 Cell-permeable peptide-based disruption of endogenous PKA-AKAP complexes: a tool for studying the molecular roles of AKAP-mediated PKA subcellular anchoring

Faruque, OM, Hani, el-H, Vives, E, Le-Nguyen, D, Lajoix, AD, Petit, P, Bataille, D

Am J Physiol Cell Physiol 2009
9405718 Anchoring of protein kinase A facilitates hormone-mediated insulin secretion

Lester, LB, Scott, JD, Langeberg, LK

Proc Natl Acad Sci U S A 1997
Participants
Input
Output
Orthologous Events
PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP (Homo sapiens)
Authored
May, B  (2009-11-19)
Reviewed
May, B  (2009-11-19)
Created
May, B  (2009-11-19)
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