Reactome | CDC42 [plasma membrane]

CDC42 [plasma membrane]

Stable Identifier

R-RNO-449545

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

Q8CFN2

Locations in the PathwayBrowser

Expand all

Developmental Biology (Rattus norvegicus)

- Myogenesis (Rattus norvegicus)
  - Nuclear translocation of p38 MAPK (Rattus norvegicus)
    - ABL1:JLP:CDO complex [plasma membrane] (Rattus norvegicus)
      - Cadherin-catenin:JLP:CDO:BOC:Bnip2-Cdc42 [plasma membrane] (Rattus norvegicus)
        
        Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP [plasma membrane] (Rattus norvegicus)
        
        CDC42 [plasma membrane] (Rattus norvegicus)
    - pp38 alpha/beta/gamma:ABL1:JLP:CDO complex [plasma membrane] (Rattus norvegicus)
      - ABL1:JLP:CDO complex [plasma membrane] (Rattus norvegicus)
        
        Cadherin-catenin:JLP:CDO:BOC:Bnip2-Cdc42 [plasma membrane] (Rattus norvegicus)
        
        Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP [plasma membrane] (Rattus norvegicus)
        
        CDC42 [plasma membrane] (Rattus norvegicus)
- Nervous system development (Rattus norvegicus)
  - Axon guidance (Rattus norvegicus)
    - EPH-Ephrin signaling (Rattus norvegicus)
      - EPHB-mediated forward signaling (Rattus norvegicus)
        
        CDC42 and PIP2 bind WASL, activating it (Rattus norvegicus)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP [plasma membrane] (Rattus norvegicus)
        
        CDC42 [plasma membrane] (Rattus norvegicus)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Rattus norvegicus)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP [plasma membrane] (Rattus norvegicus)
        
        CDC42 [plasma membrane] (Rattus norvegicus)
        
        N-WASP binds ARP2/3 and G-actin (Rattus norvegicus)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Rattus norvegicus)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP [plasma membrane] (Rattus norvegicus)
        
        CDC42 [plasma membrane] (Rattus norvegicus)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Rattus norvegicus)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Rattus norvegicus)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP [plasma membrane] (Rattus norvegicus)
        
        CDC42 [plasma membrane] (Rattus norvegicus)
    - Netrin-1 signaling (Rattus norvegicus)
      - DCC mediated attractive signaling (Rattus norvegicus)
        
        Activation of Cdc42 (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP [plasma membrane] (Rattus norvegicus)
        
        CDC42 [plasma membrane] (Rattus norvegicus)

Immune System (Rattus norvegicus)

- Adaptive Immune System (Rattus norvegicus)
  - Regulation of T cell activation by CD28 family (Rattus norvegicus)
    - Co-stimulation by CD28 (Rattus norvegicus)
      - CD28 dependent Vav1 pathway (Rattus norvegicus)
        
        Activation of Cdc42 by pVav1 (Rattus norvegicus)
        
        CDC42:GTP [plasma membrane] (Rattus norvegicus)
        
        CDC42 [plasma membrane] (Rattus norvegicus)
        
        Activation of PAKs by RAC1 and CDC42 (Rattus norvegicus)
        
        CDC42:GTP, RAC1:GTP [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP [plasma membrane] (Rattus norvegicus)
        
        CDC42 [plasma membrane] (Rattus norvegicus)
        
        PAK1,2,3:CDC42:GTP, RAC1:GTP [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP, RAC1:GTP [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP [plasma membrane] (Rattus norvegicus)
        
        CDC42 [plasma membrane] (Rattus norvegicus)
- Innate Immune System (Rattus norvegicus)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Rattus norvegicus)
    - Regulation of actin dynamics for phagocytic cup formation (Rattus norvegicus)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Rattus norvegicus)
        
        Mother filament:branching complex [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP [plasma membrane] (Rattus norvegicus)
        
        CDC42 [plasma membrane] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP [plasma membrane] (Rattus norvegicus)
        
        CDC42 [plasma membrane] (Rattus norvegicus)
      - Autophosphorylation of PAK1 (Rattus norvegicus)
        
        CDC42:GTP, RAC1:GTP [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP [plasma membrane] (Rattus norvegicus)
        
        CDC42 [plasma membrane] (Rattus norvegicus)
        
        RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP, RAC1:GTP [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP [plasma membrane] (Rattus norvegicus)
        
        CDC42 [plasma membrane] (Rattus norvegicus)
      - Detachment of WASP/WAVE (Rattus norvegicus)
        
        Mother filament:branching complex [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP [plasma membrane] (Rattus norvegicus)
        
        CDC42 [plasma membrane] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP [plasma membrane] (Rattus norvegicus)
        
        CDC42 [plasma membrane] (Rattus norvegicus)
      - RAC1 and CDC42 activate PAK1 (Rattus norvegicus)
        
        CDC42:GTP, RAC1:GTP [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP [plasma membrane] (Rattus norvegicus)
        
        CDC42 [plasma membrane] (Rattus norvegicus)
        
        RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP, RAC1:GTP [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP [plasma membrane] (Rattus norvegicus)
        
        CDC42 [plasma membrane] (Rattus norvegicus)
      - Src phosphorylate WASP,N-WASP (Rattus norvegicus)
        
        CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP [plasma membrane] (Rattus norvegicus)
        
        CDC42 [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
        
        CDC42:GTP [plasma membrane] (Rattus norvegicus)
        
        CDC42 [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q8CFN2 Cdc42

Gene Names

Cdc42

Chain

chain:1-188, propeptide:189-191

Reference Genes

BioGPS Gene:64465 Cdc42

KEGG:rno:64465 Cdc42

Monarch:64465 Cdc42

NCBI Entrez Gene:64465 Cdc42

UCSC:Q8CFN2 Cdc42

Reference Transcript

Other Identifiers

10880777

1370825_a_at

1391127_at

17602723

17602725

17602727

17602729

17602731

17602733

17811684

5636612

5771705

5845270

5869656

5964236

5985195

6197050

6266801

6356578

6404212

64465

6508422

6564007

A_44_P555019

A_44_P555021

A_44_P593020

A_64_P133202

A_64_P154982

GE21484

GO:0003924

GO:0005525

GO:0007264

GO:0016787

ILMN_1371930

PH_rn_0011606

rc_AA925473_at

rc_AA925473_g_at

rc_AI227676_at

rc_AI227887_at

rc_AI227887_g_at

Participates

as a candidate of

as a component of

as an input of

CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Rattus norvegicus)

Other forms of this molecule

CDC42 [endoplasmic reticulum membrane]

Cdc42 [cytosol]

Inferred From

CDC42 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_038966637.1, XP_063144424.1, XP_008762508.1, XP_008762509.1, NP_741991.3

ENSEMBL

ENSRNOG00000013536, ENSRNOT00000029025, ENSRNOP00000030928

PRO

Q8CFN2

RGD

71043

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.527	2

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