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Traf6 [endosome membrane]
Stable Identifier
R-RNO-450227
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
endosome membrane
Synonyms
K63polyUb-TRAF6, B5DF45
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
Toll-like Receptor Cascades (Rattus norvegicus)
Toll Like Receptor 10 (TLR10) Cascade (Rattus norvegicus)
MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
IRAK2 mediated activation of TAK1 complex (Rattus norvegicus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Rattus norvegicus)
Traf6 [endosome membrane] (Rattus norvegicus)
Toll Like Receptor 2 (TLR2) Cascade (Rattus norvegicus)
Toll Like Receptor TLR1:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
IRAK2 mediated activation of TAK1 complex (Rattus norvegicus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Rattus norvegicus)
Traf6 [endosome membrane] (Rattus norvegicus)
Toll Like Receptor TLR6:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
IRAK2 mediated activation of TAK1 complex (Rattus norvegicus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Rattus norvegicus)
Traf6 [endosome membrane] (Rattus norvegicus)
Toll Like Receptor 4 (TLR4) Cascade (Rattus norvegicus)
MyD88-independent TLR4 cascade (Rattus norvegicus)
TRIF(TICAM1)-mediated TLR4 signaling (Rattus norvegicus)
TRAF6-mediated induction of TAK1 complex within TLR4 complex (Rattus norvegicus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Rattus norvegicus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Rattus norvegicus)
Traf6 [endosome membrane] (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
IRAK2 mediated activation of TAK1 complex (Rattus norvegicus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Rattus norvegicus)
Traf6 [endosome membrane] (Rattus norvegicus)
Toll Like Receptor 5 (TLR5) Cascade (Rattus norvegicus)
MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
IRAK2 mediated activation of TAK1 complex (Rattus norvegicus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Rattus norvegicus)
Traf6 [endosome membrane] (Rattus norvegicus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Rattus norvegicus)
MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Rattus norvegicus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Rattus norvegicus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Rattus norvegicus)
Traf6 [endosome membrane] (Rattus norvegicus)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Rattus norvegicus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Rattus norvegicus)
Traf6 [endosome membrane] (Rattus norvegicus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Rattus norvegicus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Rattus norvegicus)
Traf6 [endosome membrane] (Rattus norvegicus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation (Rattus norvegicus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Rattus norvegicus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Rattus norvegicus)
Traf6 [endosome membrane] (Rattus norvegicus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [endosome membrane] (Rattus norvegicus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Rattus norvegicus)
Traf6 [endosome membrane] (Rattus norvegicus)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Rattus norvegicus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Rattus norvegicus)
Traf6 [endosome membrane] (Rattus norvegicus)
Toll Like Receptor 9 (TLR9) Cascade (Rattus norvegicus)
MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Rattus norvegicus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Rattus norvegicus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Rattus norvegicus)
Traf6 [endosome membrane] (Rattus norvegicus)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Rattus norvegicus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Rattus norvegicus)
Traf6 [endosome membrane] (Rattus norvegicus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Rattus norvegicus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Rattus norvegicus)
Traf6 [endosome membrane] (Rattus norvegicus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation (Rattus norvegicus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Rattus norvegicus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Rattus norvegicus)
Traf6 [endosome membrane] (Rattus norvegicus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [endosome membrane] (Rattus norvegicus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Rattus norvegicus)
Traf6 [endosome membrane] (Rattus norvegicus)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Rattus norvegicus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Rattus norvegicus)
Traf6 [endosome membrane] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:B5DF45
Gene Names
Traf6
Reference Genes
BioGPS Gene:311245 Traf6
ENSEMBL:ENSRNOG00000004639
KEGG Gene (Rattus norvegicus):311245 Traf6
Monarch:311245 Traf6
NCBI Gene:311245 Traf6
UCSC:B5DF45 Traf6
Reference Transcript
RefSeq:NM_001107754.2 Traf6
Other Identifiers
10838100
1393809_at
17764266
311245
5636876
5654984
5858435
5949460
6004198
6058945
6181227
6446648
6486063
6486089
6514411
6546797
6569317
A_44_P433773
GE1157937
GO:0000122
GO:0000209
GO:0001503
GO:0001701
GO:0001843
GO:0002376
GO:0002637
GO:0002726
GO:0002931
GO:0004842
GO:0005164
GO:0005515
GO:0005622
GO:0005634
GO:0005737
GO:0005811
GO:0005829
GO:0005886
GO:0005938
GO:0006351
GO:0006355
GO:0006955
GO:0006974
GO:0007155
GO:0007165
GO:0007249
GO:0007250
GO:0007254
GO:0008270
GO:0009887
GO:0009898
GO:0012501
GO:0016567
GO:0016740
GO:0019221
GO:0019886
GO:0019901
GO:0023052
GO:0030154
GO:0030316
GO:0031435
GO:0031624
GO:0031625
GO:0031666
GO:0031996
GO:0032147
GO:0032735
GO:0032743
GO:0032755
GO:0032813
GO:0032991
GO:0033209
GO:0035556
GO:0035631
GO:0036211
GO:0042088
GO:0042102
GO:0042475
GO:0042802
GO:0042826
GO:0042981
GO:0043011
GO:0043122
GO:0043123
GO:0043226
GO:0043422
GO:0043507
GO:0045453
GO:0045672
GO:0045892
GO:0045944
GO:0046330
GO:0046849
GO:0046872
GO:0047485
GO:0048468
GO:0048471
GO:0048661
GO:0048856
GO:0050852
GO:0051091
GO:0051092
GO:0051865
GO:0061630
GO:0070498
GO:0070534
GO:0070555
GO:0071222
GO:0071345
GO:0097400
GO:0140096
GO:1901224
GO:1904996
GO:2000679
ILMN_1353721
PH_rn_0015605
Participates
as a component of
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Rattus norvegicus)
Other forms of this molecule
Traf6 [cytosol]
Traf6 [cytosol]
Traf6 [endosome membrane]
Traf6 [plasma membrane]
Traf6 [plasma membrane]
Traf6 [cytosol]
Traf6 [cytosol]
Inferred From
K63polyUb-TRAF6 [endosome membrane]
(Homo sapiens)
Modified Residues
Name
ubiquitinylated lysine (K63polyUb [endosome membrane]) at 124 (in Homo sapiens)
Coordinate
124
Modification
K63polyUb [endosome membrane]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_001101224.1
Ensembl
ENSRNOP00000006148
,
ENSRNOG00000004639
,
ENSRNOT00000006148
PRO
B5DF45
RGD
1306853
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