Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
phospho-p-S218,T222-MAP2K3 [nucleoplasm]
Stable Identifier
R-RNO-450229
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
nucleoplasm
Synonyms
M0R7E7
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Cellular Senescence (Rattus norvegicus)
Oxidative Stress Induced Senescence (Rattus norvegicus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Rattus norvegicus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Rattus norvegicus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Rattus norvegicus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Rattus norvegicus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Rattus norvegicus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Rattus norvegicus)
Phosphorylated MKK3/MKK6 migrates to nucleus (Rattus norvegicus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Rattus norvegicus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-17 signaling (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Rattus norvegicus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Rattus norvegicus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Rattus norvegicus)
Phosphorylated MKK3/MKK6 migrates to nucleus (Rattus norvegicus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Rattus norvegicus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
Toll-like Receptor Cascades (Rattus norvegicus)
Toll Like Receptor 10 (TLR10) Cascade (Rattus norvegicus)
MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Rattus norvegicus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Rattus norvegicus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Rattus norvegicus)
Phosphorylated MKK3/MKK6 migrates to nucleus (Rattus norvegicus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Rattus norvegicus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Rattus norvegicus)
Toll Like Receptor 2 (TLR2) Cascade (Rattus norvegicus)
Toll Like Receptor TLR1:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Rattus norvegicus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Rattus norvegicus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Rattus norvegicus)
Phosphorylated MKK3/MKK6 migrates to nucleus (Rattus norvegicus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Rattus norvegicus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Rattus norvegicus)
Toll Like Receptor TLR6:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Rattus norvegicus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Rattus norvegicus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Rattus norvegicus)
Phosphorylated MKK3/MKK6 migrates to nucleus (Rattus norvegicus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Rattus norvegicus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Rattus norvegicus)
Toll Like Receptor 3 (TLR3) Cascade (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Rattus norvegicus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Rattus norvegicus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Rattus norvegicus)
Phosphorylated MKK3/MKK6 migrates to nucleus (Rattus norvegicus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Rattus norvegicus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Rattus norvegicus)
Toll Like Receptor 4 (TLR4) Cascade (Rattus norvegicus)
MyD88-independent TLR4 cascade (Rattus norvegicus)
TRIF (TICAM1)-mediated TLR4 signaling (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Rattus norvegicus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Rattus norvegicus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Rattus norvegicus)
Phosphorylated MKK3/MKK6 migrates to nucleus (Rattus norvegicus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Rattus norvegicus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Rattus norvegicus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Rattus norvegicus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Rattus norvegicus)
Phosphorylated MKK3/MKK6 migrates to nucleus (Rattus norvegicus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Rattus norvegicus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Rattus norvegicus)
Toll Like Receptor 5 (TLR5) Cascade (Rattus norvegicus)
MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Rattus norvegicus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Rattus norvegicus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Rattus norvegicus)
Phosphorylated MKK3/MKK6 migrates to nucleus (Rattus norvegicus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Rattus norvegicus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Rattus norvegicus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Rattus norvegicus)
MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Rattus norvegicus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Rattus norvegicus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Rattus norvegicus)
Phosphorylated MKK3/MKK6 migrates to nucleus (Rattus norvegicus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Rattus norvegicus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Rattus norvegicus)
Toll Like Receptor 9 (TLR9) Cascade (Rattus norvegicus)
MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Rattus norvegicus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Rattus norvegicus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Rattus norvegicus)
Phosphorylated MKK3/MKK6 migrates to nucleus (Rattus norvegicus)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Rattus norvegicus)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:M0R7E7
Reference Genes
ENSEMBL:ENSRNOG00000006612
ENSEMBL:ENSRNOG00000049132
ENSEMBL:ENSRNOG00000065992
ENSEMBL:ENSRNOG00000065992.1
Reference Transcript
RefSeq:XM_017597642.1
Other Identifiers
10734198
1388858_at
17646559
303200
5675259
5744291
5849738
5868012
6045848
6055860
6062690
6089713
6141510
6213819
6313111
6486301
6596246
6678937
6742051
A_43_P10006
GE1181133
GO:0000165
GO:0001817
GO:0003012
GO:0003013
GO:0003824
GO:0004672
GO:0004708
GO:0005524
GO:0006351
GO:0006355
GO:0006468
GO:0006954
GO:0016740
GO:0019901
GO:0023052
GO:0031098
GO:0035331
GO:0035924
GO:0036211
GO:0038066
GO:0043410
GO:0043536
GO:0045893
GO:0048870
GO:0060048
GO:0140096
ILMN_1373506
PH_rn_0014424
rc_AI104897_at
rc_AI171374_at
Participates
as a member of
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Rattus norvegicus)
Other forms of this molecule
MAP2K3 [cytosol]
phospho-p-S218,T222-MAP2K3 [cytosol]
Inferred From
p-S218,T222-MAP2K3 [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 218 (in Homo sapiens)
Coordinate
218
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 222 (in Homo sapiens)
Coordinate
222
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
XP_017453131.1
Ensembl
ENSRNOT00000073792
,
ENSRNOP00000065373
,
ENSRNOG00000065992
RGD
1306620
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text