Interaction of nephrin with adherens junction-associated proteins

Stable Identifier
R-RNO-451384
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
General
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Interaction of nephrin with adherens junction-associated proteins

The nephrin-slit diaphragm protein complex contains a group of scaffolding proteins that function to connect junctional membrane proteins to the actin cytoskeleton and signaling cascades. By mass spectrometry four of the proteins identified, alphaII spectrin, betaII spectrin, alpha-actinin, and IQGAP1, represent adherens junction-associated proteins, and two, MAGI-2/S-SCAM and CASK, represent MAGUK family scaffolding proteins that associate with Ig superfamily proteins. The presence of these proteins in slit diaphragms and their association with nephrin suggests that they may form a scaffolding protein complex in the podocyte slit diaphragm and thus contribute to the regulation of ultrafiltration by binding slit membrane proteins and establishing their cytosolic connections.

Literature References
PubMed ID Title Journal Year
15994232 Cell junction-associated proteins IQGAP1, MAGI-2, CASK, spectrins, and alpha-actinin are components of the nephrin multiprotein complex

Kudlicka, K, Zhou, H, Lehtonen, S, Farquhar, MG, Iino, N, Ryan, JJ

Proc Natl Acad Sci U S A 2005
15331416 Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin

Holthofer, H, Kudlicka, K, Lehtonen, S, Farquhar, MG, Lehtonen, E

Am J Pathol 2004
19478094 Slit diaphragms contain tight junction proteins

Kudlicka, K, Fukasawa, H, Farquhar, MG, Bornheimer, S

J Am Soc Nephrol 2009
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Orthologous Events
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