Nephrin binds Cask

Stable Identifier
R-RNO-451396
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Nephrin binds Cask
CASK is a scaffolding protein that participates in maintenance of polarized epithelial cell architecture by linking membrane proteins and signaling molecules to the actin cytoskeleton. CASK is identified as one of the binding partners of nephrin and this interaction likely plays an important role in establishing the structural integrity and functional properties of the glomerular slit diaphragm.
Literature References
PubMed ID Title Journal Year
15331416 Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin

Holthofer, H, Kudlicka, K, Lehtonen, S, Farquhar, MG, Lehtonen, E

Am J Pathol 2004
15994232 Cell junction-associated proteins IQGAP1, MAGI-2, CASK, spectrins, and alpha-actinin are components of the nephrin multiprotein complex

Kudlicka, K, Zhou, H, Lehtonen, S, Farquhar, MG, Iino, N, Ryan, JJ

Proc Natl Acad Sci U S A 2005
Participants
Input
Output
Orthologous Events
Nephrin binds CASK (Homo sapiens)
Authored
Garapati, P V  (2008-02-26)
de Bono, B  (2008-02-26)
Reviewed
Grahammer, Florian  (2010-05-20)
Huber, TB  (2010-05-20)
Created
Garapati, P V  (2010-01-05)
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