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phospho-Nfkb1 [cytosol]
Stable Identifier
R-RNO-451619
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
3xUb-p-S927,S932-NFKB1(1-968), Q63369
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-1 family signaling (Rattus norvegicus)
Interleukin-1 signaling (Rattus norvegicus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Rattus norvegicus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
Interleukin-17 signaling (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Rattus norvegicus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
Toll-like Receptor Cascades (Rattus norvegicus)
Toll Like Receptor 10 (TLR10) Cascade (Rattus norvegicus)
MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Rattus norvegicus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
Toll Like Receptor 2 (TLR2) Cascade (Rattus norvegicus)
Toll Like Receptor TLR1:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Rattus norvegicus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
Toll Like Receptor TLR6:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Rattus norvegicus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
Toll Like Receptor 3 (TLR3) Cascade (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Rattus norvegicus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
Toll Like Receptor 4 (TLR4) Cascade (Rattus norvegicus)
MyD88-independent TLR4 cascade (Rattus norvegicus)
TRIF (TICAM1)-mediated TLR4 signaling (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Rattus norvegicus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Rattus norvegicus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
Toll Like Receptor 5 (TLR5) Cascade (Rattus norvegicus)
MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Rattus norvegicus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Rattus norvegicus)
MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Rattus norvegicus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
Toll Like Receptor 9 (TLR9) Cascade (Rattus norvegicus)
MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Rattus norvegicus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Rattus norvegicus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
phospho-Nfkb1 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q63369
Gene Names
Nfkb1
Reference Genes
BioGPS Gene:81736 Nfkb1
ENSEMBL:ENSRNOG00000023258
Monarch:81736 Nfkb1
NCBI Gene:81736 Nfkb1
UCSC:Q63369 Nfkb1
Reference Transcript
RefSeq:NM_001415012.1 Nfkb1
RefSeq:XM_006233358.3 Nfkb1
Participates
as a component of
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Rattus norvegicus)
This entity regulates
Negatively
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex
(Rattus norvegicus)
Other forms of this molecule
Nfkb1 [secretory granule lumen]
Nfkb1 [extracellular region]
Nfkb1 [specific granule lumen]
Nfkb1 [cytosol]
Nfkb1 [nucleoplasm]
Nfkb1 [cytosol]
phospho-Nfkb1 [cytosol]
Inferred From
3xUb-p-S927,S932-NFKB1(1-968) [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 927 (in Homo sapiens)
Coordinate
927
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 932 (in Homo sapiens)
Coordinate
932
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position
Modification
K48polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position
Modification
K48polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position
Modification
K48polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_001401941.1
,
XP_006233420.1
RGD
70498
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P47196 Akt1
11
phospho-Akt1 [cytosol]
(R-RNO-9841264)
phospho-Akt1 [cytosol]
(R-RNO-8848757)
phospho-Akt1 [plasma membrane]
(R-RNO-199430)
phospho-Akt1 [cytosol]
(R-RNO-198634)
Phospho-Akt1 [nucleoplasm]
(R-RNO-198325)
Phospho-Akt1 [cytosol]
(R-RNO-198376)
Akt1 [cytosol]
(R-RNO-437274)
Akt1 [plasma membrane]
(R-RNO-199416)
phospho-Akt1 [plasma membrane]
(R-RNO-377265)
phospho-Akt1 [cytosol]
(R-RNO-198356)
phospho-Akt1 [nucleoplasm]
(R-RNO-198357)
0.61
9
UniProt:Q99N34
2
Dffb [cytosol]
(R-RNO-211211)
Dffb [nucleoplasm]
(R-RNO-211195)
0.544
2
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