Reactome | Jak3 [cytosol]

Jak3 [cytosol]

Stable Identifier

R-RNO-451893

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

JAK3, Q63272

Locations in the PathwayBrowser

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Immune System (Rattus norvegicus)

- Cytokine Signaling in Immune system (Rattus norvegicus)
  - Signaling by Interleukins (Rattus norvegicus)
    - Interleukin-2 family signaling (Rattus norvegicus)
      - Interleukin receptor SHC signaling (Rattus norvegicus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Rattus norvegicus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        Phosphorylated SHC recruits GRB2:SOS1 (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Rattus norvegicus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        Phosphorylated SHC1 recruits SHIP (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Rattus norvegicus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        The SHC1:SHIP1 complex is stabilized by GRB2 (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
      - Interleukin-15 signaling (Rattus norvegicus)
        
        IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Rattus norvegicus)
        
        IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Rattus norvegicus)
        
        IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
      - Interleukin-2 signaling (Rattus norvegicus)
        
        JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        JAK3 binds JAK3 inhibitors (Rattus norvegicus)
        
        JAK3:JAK3 inhibitors [cytosol] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        PTK2B binds JAK3 (Rattus norvegicus)
        
        JAK3:PYK2 [cytosol] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        PTK2B is phosphorylated (Rattus norvegicus)
        
        JAK3:PYK2 [cytosol] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        JAK3:p-PYK2 [cytosol] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        Phosphorylated STAT5 is released (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,Y392, Y510) beta subunit:p-JAK1:JAK3:p-STAT5 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        Phosphorylation of IL2RB Y338 enables SHC recruitment (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        Recruited STAT5 is phosphorylated (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,Y392, Y510) beta subunit:p-JAK1:JAK3:p-STAT5 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        SHC1 bound to IL2 receptor is phosphorylated (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        SYK binds IL2RB (Rattus norvegicus)
        
        IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        SYK is a substrate for JAK1 (Rattus norvegicus)
        
        IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        IL2:IL2R trimer:p-JAK1:JAK3:p-SYK [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        Within the IL-2R complex JAK3 phosphorylates JAK1 (Rattus norvegicus)
        
        IL2:IL2R trimer:JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
      - Interleukin-21 signaling (Rattus norvegicus)
        
        IL21 receptor JAK phosphorylation (Rattus norvegicus)
        
        IL21:IL21R:JAK1:IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
      - Interleukin-9 signaling (Rattus norvegicus)
        
        IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Rattus norvegicus)
        
        IL9:IL9R:JAK1:IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        JAK3 binds JAK3 inhibitors (Rattus norvegicus)
        
        JAK3:JAK3 inhibitors [cytosol] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
    - Interleukin-20 family signaling (Rattus norvegicus)
      - IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Rattus norvegicus)
        
        IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 [plasma membrane] (Rattus norvegicus)
        
        JAK2, JAK3 [cytosol] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        JAK2, JAK3 [cytosol] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
      - IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Rattus norvegicus)
        
        IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 [plasma membrane] (Rattus norvegicus)
        
        JAK2, JAK3 [cytosol] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Rattus norvegicus)
      - Interleukin receptor SHC signaling (Rattus norvegicus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Rattus norvegicus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        Phosphorylated SHC recruits GRB2:SOS1 (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Rattus norvegicus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        Phosphorylated SHC1 recruits SHIP (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Rattus norvegicus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        The SHC1:SHIP1 complex is stabilized by GRB2 (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Rattus norvegicus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
    - Interleukin-4 and Interleukin-13 signaling (Rattus norvegicus)
      - IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Rattus norvegicus)
        
        IL4:IL4R:JAK2:IL2RG:JAK3:JAK1 [plasma membrane] (Rattus norvegicus)
        
        IL4:IL4R:JAK2:IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        p-Y-IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
      - JAK1 binds IL4R in IL4-bound IL4R1 (Rattus norvegicus)
        
        IL4:IL4R:JAK2:IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        IL4:IL4R:JAK2:IL2RG:JAK3:JAK1 [plasma membrane] (Rattus norvegicus)
        
        IL4:IL4R:JAK2:IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
      - JAK1 phosphorylates STAT3,STAT6 (Rattus norvegicus)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:STAT3,STAT6 [plasma membrane] (Rattus norvegicus)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        p-Y-IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:p-Y705-STAT3,p-Y641-STAT6 [plasma membrane] (Rattus norvegicus)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        p-Y-IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
      - JAK3 binds JAK3 inhibitors (Rattus norvegicus)
        
        JAK3:JAK3 inhibitors [cytosol] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
      - STAT3,STAT6 bind p-Y-IL4R (Rattus norvegicus)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        p-Y-IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:STAT3,STAT6 [plasma membrane] (Rattus norvegicus)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        p-Y-IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
      - p-Y705-STAT3,p-Y641-STAT6 dissociate (Rattus norvegicus)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        p-Y-IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:p-Y705-STAT3,p-Y641-STAT6 [plasma membrane] (Rattus norvegicus)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        p-Y-IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
    - Interleukin-7 signaling (Rattus norvegicus)
      - JAK3 binds JAK3 inhibitors (Rattus norvegicus)
        
        JAK3:JAK3 inhibitors [cytosol] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)
      - JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Rattus norvegicus)
        
        IL7:IL7R:JAK1:IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        IL2RG:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Jak3 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q63272

Gene Names

Jak3

Reference Genes

BioGPS Gene:25326 Jak3

ENSEMBL:ENSRNOG00000018669

KEGG:rno:25326 Jak3

Monarch:25326 Jak3

NCBI Gene:25326 Jak3

UCSC:Q63272 Jak3

Reference Transcript

Other Identifiers

10787364

10787391

1368251_at

1388241_at

17706947

17706975

25326

5651373

5682826

5701891

5720559

5772728

5797650

5799336

5827634

5928979

5947322

5956418

6003725

6050897

6080417

6125394

6126306

6126458

6155164

6165794

6200398

6212356

6222818

6226964

6277601

6291674

6427837

6486258

6535913

6582585

6592653

A_42_P492542

A_64_P086148

D28508_at

GE20012

GE21587

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0005524

GO:0005856

GO:0006468

GO:0016020

GO:0016740

GO:0035556

GO:0043226

GO:0140096

ILMN_1355371

ILMN_1362150

PH_rn_0012279

Participates

as a candidate of

JAK2, JAK3 [cytosol] (Rattus norvegicus)

as an input of

as a component of

Other forms of this molecule

phospho-Jak3 [cytosol]

phospho-Jak3 [plasma membrane]

Jak3 [endosome]

phospho-Jak3 [cytosol]

Inferred From

JAK3 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_036987.2, XP_063131138.1, XP_038950131.1, XP_008769286.1

ENSEMBL

ENSRNOT00000025312, ENSRNOP00000025312, ENSRNOG00000018669

PRO

Q63272

RGD

2940

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