Reactome | Mbd3 [nucleoplasm]

Mbd3 [nucleoplasm]

Stable Identifier

R-RNO-4657010

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

nucleoplasm

Synonyms

MBD3, F7EY92

Locations in the PathwayBrowser

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Chromatin organization (Rattus norvegicus)

- Chromatin modifying enzymes (Rattus norvegicus)
  - HDACs deacetylate histones (Rattus norvegicus)
    - HDAC1:2-containing complex binds HDAC2 Inhibitors (Rattus norvegicus)
      - HDAC1:2-containing complex [nucleoplasm] (Rattus norvegicus)
        
        NuRD complex [nucleoplasm] (Rattus norvegicus)
        
        Mbd3 [nucleoplasm] (Rattus norvegicus)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Rattus norvegicus)
        
        HDAC1:2-containing complex [nucleoplasm] (Rattus norvegicus)
        
        NuRD complex [nucleoplasm] (Rattus norvegicus)
        
        Mbd3 [nucleoplasm] (Rattus norvegicus)

Gene expression (Transcription) (Rattus norvegicus)

- RNA Polymerase I Transcription (Rattus norvegicus)
  - RNA Polymerase I Promoter Clearance (Rattus norvegicus)
    - RNA Polymerase I Transcription Initiation (Rattus norvegicus)
      - Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Rattus norvegicus)
        
        TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Rattus norvegicus)
        
        NuRD complex [nucleoplasm] (Rattus norvegicus)
        
        Mbd3 [nucleoplasm] (Rattus norvegicus)
- RNA Polymerase II Transcription (Rattus norvegicus)
  - Generic Transcription Pathway (Rattus norvegicus)
    - Transcriptional Regulation by TP53 (Rattus norvegicus)
      - Regulation of TP53 Activity (Rattus norvegicus)
        
        Regulation of TP53 Activity through Acetylation (Rattus norvegicus)
        
        MTA2-NuRD complex deacetylates TP53 (Rattus norvegicus)
        
        MTA2-NuRD complex [nucleoplasm] (Rattus norvegicus)
        
        Mbd3 [nucleoplasm] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- Intracellular signaling by second messengers (Rattus norvegicus)
  - PIP3 activates AKT signaling (Rattus norvegicus)
    - PTEN Regulation (Rattus norvegicus)
      - Regulation of PTEN gene transcription (Rattus norvegicus)
        
        SALL4 recruits NuRD to PTEN gene (Rattus norvegicus)
        
        NuRD complex [nucleoplasm] (Rattus norvegicus)
        
        Mbd3 [nucleoplasm] (Rattus norvegicus)
        
        SALL4:NuRD:PTEN gene [nucleoplasm] (Rattus norvegicus)
        
        SALL4:NuRD [nucleoplasm] (Rattus norvegicus)
        
        NuRD complex [nucleoplasm] (Rattus norvegicus)
        
        Mbd3 [nucleoplasm] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:F7EY92

Gene Names

Mbd3

Reference Genes

BioGPS Gene:362834 Mbd3

ENSEMBL:ENSRNOG00000028956

ENSEMBL:ENSRNOG00000028956.6 Mbd3

Monarch:362834 Mbd3

NCBI Gene:362834 Mbd3

Reference Transcript

RefSeq:XM_008765120.1 Mbd3

Other Identifiers

10893852

1371345_at

17826393

362834

5694732

5861885

5894054

5964615

6108631

6386004

6423223

6496830

6551153

6574095

6619248

A_44_P272324

A_64_P030554

GE13617

GO:0000122

GO:0000785

GO:0000792

GO:0001701

GO:0003677

GO:0003682

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006325

GO:0006338

GO:0006346

GO:0006351

GO:0006355

GO:0008327

GO:0009888

GO:0016581

GO:0032991

GO:0043226

GO:0048856

ILMN_1359297

PH_rn_0008140

rc_AI008699_at

Participates

as a component of

Inferred From

MBD3 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_008763342.1

Ensembl

ENSRNOG00000028956, ENSRNOP00000041242, ENSRNOT00000049170

RGD

1307389