Reactome | Cdc7 [nucleoplasm]

Cdc7 [nucleoplasm]

Stable Identifier

R-RNO-51781

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

nucleoplasm

Synonyms

CDC7, D4A8S5

Locations in the PathwayBrowser

Expand all

Cell Cycle (Rattus norvegicus)

- Cell Cycle Checkpoints (Rattus norvegicus)
  - G2/M Checkpoints (Rattus norvegicus)
    - Activation of ATR in response to replication stress (Rattus norvegicus)
      - Activation of claspin (Rattus norvegicus)
        
        Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Rattus norvegicus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Rattus norvegicus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
        
        DDK [nucleoplasm] (Rattus norvegicus)
        
        Cdc7 [nucleoplasm] (Rattus norvegicus)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Rattus norvegicus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Rattus norvegicus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
        
        DDK [nucleoplasm] (Rattus norvegicus)
        
        Cdc7 [nucleoplasm] (Rattus norvegicus)
      - Loading of claspin onto DNA during replication origin firing (Rattus norvegicus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Rattus norvegicus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
        
        DDK [nucleoplasm] (Rattus norvegicus)
        
        Cdc7 [nucleoplasm] (Rattus norvegicus)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Rattus norvegicus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Rattus norvegicus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
        
        DDK [nucleoplasm] (Rattus norvegicus)
        
        Cdc7 [nucleoplasm] (Rattus norvegicus)
- Cell Cycle, Mitotic (Rattus norvegicus)
  - Mitotic G1 phase and G1/S transition (Rattus norvegicus)
    - G1/S Transition (Rattus norvegicus)
      - Activation of the pre-replicative complex (Rattus norvegicus)
        
        CDK and DDK associate with the Mcm10:pre-replicative complex (Rattus norvegicus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
        
        DDK [nucleoplasm] (Rattus norvegicus)
        
        Cdc7 [nucleoplasm] (Rattus norvegicus)
        
        DDK [nucleoplasm] (Rattus norvegicus)
        
        Cdc7 [nucleoplasm] (Rattus norvegicus)
        
        DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Rattus norvegicus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Rattus norvegicus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
        
        DDK [nucleoplasm] (Rattus norvegicus)
        
        Cdc7 [nucleoplasm] (Rattus norvegicus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Rattus norvegicus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Rattus norvegicus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
        
        DDK [nucleoplasm] (Rattus norvegicus)
        
        Cdc7 [nucleoplasm] (Rattus norvegicus)
        
        DNA polymerase alpha:primase binds at the origin (Rattus norvegicus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Rattus norvegicus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Rattus norvegicus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
        
        DDK [nucleoplasm] (Rattus norvegicus)
        
        Cdc7 [nucleoplasm] (Rattus norvegicus)
        
        DNA polymerase epsilon binds at the origin (Rattus norvegicus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Rattus norvegicus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Rattus norvegicus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
        
        DDK [nucleoplasm] (Rattus norvegicus)
        
        Cdc7 [nucleoplasm] (Rattus norvegicus)
        
        Mcm2-7 is phosphorylated by DDK (Rattus norvegicus)
        
        DDK [nucleoplasm] (Rattus norvegicus)
        
        Cdc7 [nucleoplasm] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:D4A8S5

Gene Names

Cdc7

Reference Genes

BioGPS Gene:360908 Cdc7

ENSEMBL:ENSRNOG00000002105

ENSEMBL:ENSRNOG00000002105.7 Cdc7

KEGG Gene (Rattus norvegicus):360908 Cdc7

Monarch:360908 Cdc7

NCBI Gene:360908 Cdc7

Reference Transcript

Other Identifiers

10775231

17692682

360908

5645856

5648225

5737189

5775132

6000033

6061915

6107497

6271813

6339486

6369916

6508221

6546579

6589238

6683930

6723482

6735495

A_43_P21295

E12365cds_at

GO:0000278

GO:0003824

GO:0004672

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005856

GO:0006260

GO:0006468

GO:0008284

GO:0010571

GO:0010971

GO:0016301

GO:0016740

GO:0036211

GO:0043226

GO:0044770

GO:0045171

GO:0072686

GO:0140096

ILMN_1358194

PH_rn_0007965

Participates

as a component of

DDK [nucleoplasm] (Rattus norvegicus)

Inferred From

CDC7 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_017454768.1, NP_001101822.1

Ensembl

ENSRNOP00000059094, ENSRNOT00000068520, ENSRNOG00000002105

RGD

1308351

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