Reactome | phospho-Mlkl [cytosol]

phospho-Mlkl [cytosol]

Stable Identifier

R-RNO-5218903

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

p-T357,S358-MLKL, D3ZKP6

Locations in the PathwayBrowser

Expand all

Programmed Cell Death (Rattus norvegicus)

- Regulated Necrosis (Rattus norvegicus)
  - RIPK1-mediated regulated necrosis (Rattus norvegicus)
    - MLKL binds PIPs (Rattus norvegicus)
      - RIP1:RIP3:MLKL oligomer:PIPs [plasma membrane] (Rattus norvegicus)
        
        p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
        
        p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
        
        phospho-Mlkl [cytosol] (Rattus norvegicus)
      - p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
        
        p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
        
        phospho-Mlkl [cytosol] (Rattus norvegicus)
      - p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:FLOT1:FLOT2 [plasma membrane] (Rattus norvegicus)
        
        p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
        
        p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
        
        phospho-Mlkl [cytosol] (Rattus norvegicus)
      - p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:PDCD6IP:SDCBP [cytosol] (Rattus norvegicus)
        
        p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
        
        p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
        
        phospho-Mlkl [cytosol] (Rattus norvegicus)
    - RIPK3 phosphorylates MLKL (Rattus norvegicus)
      - (p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Rattus norvegicus)
        
        phospho-Mlkl [cytosol] (Rattus norvegicus)
    - Regulation of necroptotic cell death (Rattus norvegicus)
      - MLKL binds FLOT1, FLOT2 (Rattus norvegicus)
        
        p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
        
        p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
        
        phospho-Mlkl [cytosol] (Rattus norvegicus)
        
        p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:FLOT1:FLOT2 [plasma membrane] (Rattus norvegicus)
        
        p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
        
        p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
        
        phospho-Mlkl [cytosol] (Rattus norvegicus)
      - MLKL binds IP4, IP5 and IP6 (Rattus norvegicus)
        
        (p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Rattus norvegicus)
        
        phospho-Mlkl [cytosol] (Rattus norvegicus)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer:4xMLKL:IP6,IP5, IP4 [cytosol] (Rattus norvegicus)
        
        (p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Rattus norvegicus)
        
        phospho-Mlkl [cytosol] (Rattus norvegicus)
      - MLKL binds PDCD6IP and SDCBP (Rattus norvegicus)
        
        p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
        
        p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
        
        phospho-Mlkl [cytosol] (Rattus norvegicus)
        
        p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:PDCD6IP:SDCBP [cytosol] (Rattus norvegicus)
        
        p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
        
        p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)
        
        phospho-Mlkl [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:D3ZKP6

Gene Names

Mlkl

Reference Genes

BioGPS Gene:690743 Mlkl

ENSEMBL:ENSRNOG00000042353

ENSEMBL:ENSRNOG00000042353 Mlkl

KEGG Gene (Rattus norvegicus):690743 Mlkl

Monarch:690743 Mlkl

NCBI Gene:690743 Mlkl

UCSC:D3ZKP6 Mlkl

Reference Transcript

Other Identifiers

17733638

5761770

5782018

5893919

6185061

6360339

6428113

6484152

6575101

6659401

6676306

690743

A_44_P520603

GO:0002376

GO:0003674

GO:0004672

GO:0004706

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0006464

GO:0006468

GO:0006950

GO:0007165

GO:0007166

GO:0007256

GO:0007257

GO:0008150

GO:0008219

GO:0016301

GO:0019899

GO:0019901

GO:0022607

GO:0030054

GO:0042802

GO:0043167

GO:0043226

GO:0044877

GO:0051607

GO:0065003

GO:0070207

GO:0070266

GO:0097527

GO:0097528

PH_rn_0020326

Participates

as a repeated unit of

p-T357,S358-MLKL oligomer [cytosol] (Rattus norvegicus)

as a component of

(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Rattus norvegicus)

Other forms of this molecule

Mlkl [cytosol]

Inferred From

p-T357,S358-MLKL [cytosol] (Homo sapiens)

Modified Residues

Name

O-phospho-L-serine at 358 (in Homo sapiens)

Coordinate

358

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 357 (in Homo sapiens)

Coordinate

357

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

XP_008770792.1, XP_008770794.1, XP_008772460.1, XP_006222800.1, XP_006222799.1, XP_003753159.1, XP_008770793.1, XP_008772459.1

Ensembl

ENSRNOG00000042353, ENSRNOP00000034575, ENSRNOT00000036972

RGD

1592221

PDB

6VBZ

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