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Ercc8 [nucleoplasm]
Stable Identifier
R-RNO-52835
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
nucleoplasm
Synonyms
ERCC8, G3V7B8
Locations in the PathwayBrowser
Expand all
DNA Repair (Rattus norvegicus)
Nucleotide Excision Repair (Rattus norvegicus)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Rattus norvegicus)
Dual incision in TC-NER (Rattus norvegicus)
3' incision by ERCC5 (XPG) in TC-NER (Rattus norvegicus)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Ercc8 [nucleoplasm] (Rattus norvegicus)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Ercc8 [nucleoplasm] (Rattus norvegicus)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Rattus norvegicus)
TC-NER incision complex [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Ercc8 [nucleoplasm] (Rattus norvegicus)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Ercc8 [nucleoplasm] (Rattus norvegicus)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Rattus norvegicus)
TC-NER incision complex [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Ercc8 [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Ercc8 [nucleoplasm] (Rattus norvegicus)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Rattus norvegicus)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Ercc8 [nucleoplasm] (Rattus norvegicus)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Ercc8 [nucleoplasm] (Rattus norvegicus)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Rattus norvegicus)
TC-NER pre-incision complex [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Ercc8 [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Ercc8 [nucleoplasm] (Rattus norvegicus)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Ercc8 [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Ercc8 [nucleoplasm] (Rattus norvegicus)
ERCC5 and RPA bind TC-NER site (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Ercc8 [nucleoplasm] (Rattus norvegicus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Ercc8 [nucleoplasm] (Rattus norvegicus)
Formation of TC-NER Pre-Incision Complex (Rattus norvegicus)
ERCC8 (CSA) binds stalled RNA Pol II (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1:COP9 Signalosome [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Ercc8 [nucleoplasm] (Rattus norvegicus)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Ercc8 [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Ercc8 [nucleoplasm] (Rattus norvegicus)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Ercc8 [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Ercc8 [nucleoplasm] (Rattus norvegicus)
UVSSA:USP7 deubiquitinates ERCC6 (Rattus norvegicus)
TC-NER pre-incision complex [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Ercc8 [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Rattus norvegicus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Ercc8 [nucleoplasm] (Rattus norvegicus)
Gap-filling DNA repair synthesis and ligation in TC-NER (Rattus norvegicus)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Rattus norvegicus)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Ercc8 [nucleoplasm] (Rattus norvegicus)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Ercc8 [nucleoplasm] (Rattus norvegicus)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Rattus norvegicus)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Ercc8 [nucleoplasm] (Rattus norvegicus)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Ercc8 [nucleoplasm] (Rattus norvegicus)
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
Neddylation (Rattus norvegicus)
AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Rattus norvegicus)
NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm] (Rattus norvegicus)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Rattus norvegicus)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Rattus norvegicus)
DCAF protein [nucleoplasm] (Rattus norvegicus)
Ercc8 [nucleoplasm] (Rattus norvegicus)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Rattus norvegicus)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Rattus norvegicus)
DCAF protein [nucleoplasm] (Rattus norvegicus)
Ercc8 [nucleoplasm] (Rattus norvegicus)
CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Rattus norvegicus)
CRL4 E3 ubiquitin ligase:CAND1 [nucleoplasm] (Rattus norvegicus)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Rattus norvegicus)
DCAF protein [nucleoplasm] (Rattus norvegicus)
Ercc8 [nucleoplasm] (Rattus norvegicus)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Rattus norvegicus)
DCAF protein [nucleoplasm] (Rattus norvegicus)
Ercc8 [nucleoplasm] (Rattus norvegicus)
COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Rattus norvegicus)
CRL4 E3 ubiquitin ligase:CAND1 [nucleoplasm] (Rattus norvegicus)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Rattus norvegicus)
DCAF protein [nucleoplasm] (Rattus norvegicus)
Ercc8 [nucleoplasm] (Rattus norvegicus)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Rattus norvegicus)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Rattus norvegicus)
DCAF protein [nucleoplasm] (Rattus norvegicus)
Ercc8 [nucleoplasm] (Rattus norvegicus)
COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Rattus norvegicus)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Rattus norvegicus)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Rattus norvegicus)
DCAF protein [nucleoplasm] (Rattus norvegicus)
Ercc8 [nucleoplasm] (Rattus norvegicus)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Rattus norvegicus)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Rattus norvegicus)
DCAF protein [nucleoplasm] (Rattus norvegicus)
Ercc8 [nucleoplasm] (Rattus norvegicus)
NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Rattus norvegicus)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Rattus norvegicus)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Rattus norvegicus)
DCAF protein [nucleoplasm] (Rattus norvegicus)
Ercc8 [nucleoplasm] (Rattus norvegicus)
NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm] (Rattus norvegicus)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Rattus norvegicus)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Rattus norvegicus)
DCAF protein [nucleoplasm] (Rattus norvegicus)
Ercc8 [nucleoplasm] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:G3V7B8
Gene Names
Ercc8
Reference Genes
BioGPS Gene:310071 Ercc8
ENSEMBL:ENSRNOG00000009968
KEGG Gene (Rattus norvegicus):310071 Ercc8
Monarch:310071 Ercc8
NCBI Gene:310071 Ercc8
Reference Transcript
RefSeq:NM_001107650.2 Ercc8
Other Identifiers
10812906
1379299_at
1392907_at
17735644
310071
5628957
5638125
5783539
5827362
5892714
6028806
6086446
6108813
6145457
6166289
6176428
6251476
6342131
6394371
6471271
6483135
6488373
6553302
6666940
6739173
A_44_P535959
GE1200580
GE12878
GO:0000012
GO:0000109
GO:0000209
GO:0003674
GO:0004842
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0006259
GO:0006283
GO:0006464
GO:0006950
GO:0006974
GO:0006979
GO:0008150
GO:0009056
GO:0009411
GO:0010165
GO:0010996
GO:0014070
GO:0016363
GO:0031464
GO:0032991
GO:0034641
GO:0043161
GO:0043204
GO:0043226
GO:0044877
GO:0050896
GO:0051865
GO:0080008
GO:0090262
GO:0097680
GO:0110165
ILMN_1366313
PH_rn_0010965
rc_AA800156_at
rc_AA945763_at
Participates
as a member of
DCAF protein [nucleoplasm] (Rattus norvegicus)
as a component of
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Rattus norvegicus)
Inferred From
ERCC8 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_001101120.2
Ensembl
ENSRNOP00000013598
,
ENSRNOT00000013598
,
ENSRNOG00000009968
RGD
1311570
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