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VCP hexamer [cytosol]
Stable Identifier
R-RNO-5362364
Type
Complex
Species
Rattus norvegicus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Cellular response to chemical stress (Rattus norvegicus)
KEAP1-NFE2L2 pathway (Rattus norvegicus)
UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Rattus norvegicus)
NPLOC4:UBF1:VCP hexamer [cytosol] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Rattus norvegicus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Rattus norvegicus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Rattus norvegicus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Rattus norvegicus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
Asparagine N-linked glycosylation (Rattus norvegicus)
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Rattus norvegicus)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Rattus norvegicus)
Deglycosylation complex [endoplasmic reticulum membrane] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
Neddylation (Rattus norvegicus)
UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Rattus norvegicus)
NPLOC4:UBF1:VCP hexamer [cytosol] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Rattus norvegicus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Rattus norvegicus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Rattus norvegicus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Rattus norvegicus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Signaling by Hedgehog (Rattus norvegicus)
Hedgehog ligand biogenesis (Rattus norvegicus)
C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Rattus norvegicus)
C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Rattus norvegicus)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
SYVN1 ubiquitinates Hh C-terminal fragments (Rattus norvegicus)
C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Rattus norvegicus)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Rattus norvegicus)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Rattus norvegicus)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Rattus norvegicus)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
Transport of small molecules (Rattus norvegicus)
ABC-family proteins mediated transport (Rattus norvegicus)
CFTR binds components of the ERAD machinery for ubiquitination and degradation (Rattus norvegicus)
ERAD complex [endoplasmic reticulum membrane] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Rattus norvegicus)
ERAD complex [endoplasmic reticulum membrane] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
RNF5 and RNF185 ubiquitinate misfolded CFTR (Rattus norvegicus)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Rattus norvegicus)
ERAD complex [endoplasmic reticulum membrane] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Rattus norvegicus)
ERAD complex [endoplasmic reticulum membrane] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Rattus norvegicus)
ERAD complex [endoplasmic reticulum membrane] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Rattus norvegicus)
ERAD complex [endoplasmic reticulum membrane] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 6
VCP [cytosol]
(Rattus norvegicus)
Participates
as a component of
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Rattus norvegicus)
ERAD complex [endoplasmic reticulum membrane] (Rattus norvegicus)
NPLOC4:UBF1:VCP hexamer [cytosol] (Rattus norvegicus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Rattus norvegicus)
Deglycosylation complex [endoplasmic reticulum membrane] (Rattus norvegicus)
Inferred From
VCP hexamer [cytosol]
(Homo sapiens)
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