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POLB [nucleoplasm]
Stable Identifier
R-RNO-53845
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
nucleoplasm
Synonyms
P06766
Locations in the PathwayBrowser
Expand all
DNA Repair (Rattus norvegicus)
Base Excision Repair (Rattus norvegicus)
Resolution of Abasic Sites (AP sites) (Rattus norvegicus)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Rattus norvegicus)
LIG3 ligates NEIL1,NEIL2-generated single strand break (Rattus norvegicus)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:dsDNA [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Rattus norvegicus)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Rattus norvegicus)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
NEIL1,NEIL2 recruits POLB to incised AP site (Rattus norvegicus)
NEIL1:NEIL2:POLB:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Rattus norvegicus)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Rattus norvegicus)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Rattus norvegicus)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
NEIL1:NEIL2:POLB:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Rattus norvegicus)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Rattus norvegicus)
PCNA-Dependent Long Patch Base Excision Repair (Rattus norvegicus)
PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Rattus norvegicus)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
POLB:APEX1:SSB(5'ddRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
POLB-Dependent Long Patch Base Excision Repair (Rattus norvegicus)
LIG1 binds POLB at long-patch BER site (Rattus norvegicus)
LIG1:POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
LIG1 bound to POLB ligates SSB (Rattus norvegicus)
LIG1:POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
LIG1:POLB:dsDNA [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Rattus norvegicus)
FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Rattus norvegicus)
PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Rattus norvegicus)
PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
POLB-mediated DNA strand displacement synthesis (Rattus norvegicus)
PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
Recruitment of POLB to oxidatively damaged AP site (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
POLB:APEX1:SSB(5'ddRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
Resolution of AP sites via the single-nucleotide replacement pathway (Rattus norvegicus)
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway (Rattus norvegicus)
Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
POLB:APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
POLB:SSB-gap-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
Recruitment of POLB to the AP site (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
POLB:APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Rattus norvegicus)
LIG3:XRCC1:POLB:SSB-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
LIG3:XRCC1:POLB:dsDNA [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Rattus norvegicus)
LIG3:XRCC1:POLB:SSB-gap-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB:SSB-gap-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
POLB:SSB-gap-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
Resynthesis of excised residue by POLB (Rattus norvegicus)
LIG3:XRCC1:POLB:SSB-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
LIG3:XRCC1:POLB:SSB-gap-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB:SSB-gap-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
Deubiquitination (Rattus norvegicus)
Ub-specific processing proteases (Rattus norvegicus)
USP47 deubiquitinates POLB (Rattus norvegicus)
USP47:POLB [nucleoplasm] (Rattus norvegicus)
POLB [nucleoplasm] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P06766
Reference Genes
BioGPS Gene:29240
ENSEMBL:ENSRNOG00000019150
ENSEMBL:ENSRNOG00055007682
ENSEMBL:ENSRNOG00060027954
ENSEMBL:ENSRNOG00065008755
Monarch:29240
NCBI Gene:29240
UCSC:P06766
Reference Transcript
RefSeq:NM_017141.2
Other Identifiers
10789110
1368341_at
1387142_at
17708893
29240
5631601
5688338
5692676
5729704
5852352
5907832
5943638
5983856
6122718
6156154
6230022
6251986
6334653
6395689
6515591
6576782
6694847
6714463
A_44_P1028878
A_44_P175345
GE1158491
GE20369
GO:0001701
GO:0002376
GO:0003677
GO:0003824
GO:0003887
GO:0005634
GO:0005737
GO:0005856
GO:0005874
GO:0005876
GO:0006281
GO:0006284
GO:0006287
GO:0006310
GO:0006915
GO:0006954
GO:0006974
GO:0007435
GO:0008017
GO:0008092
GO:0008630
GO:0012501
GO:0016445
GO:0016446
GO:0016740
GO:0016779
GO:0016829
GO:0019899
GO:0023052
GO:0032991
GO:0034061
GO:0043226
GO:0048535
GO:0048536
GO:0048856
GO:0048872
GO:0051402
GO:0051575
GO:0071707
GO:0140078
GO:0140097
ILMN_1376341
J02776_s_at
PH_rn_0005484
U38801_at
rc_AA957640_s_at
Participates
as a component of
USP47:POLB [nucleoplasm] (Rattus norvegicus)
LIG3:XRCC1:POLB:dsDNA [nucleoplasm] (Rattus norvegicus)
LIG3:XRCC1:POLB:SSB-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB:APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB:SSB-gap-dsDNA [nucleoplasm] (Rattus norvegicus)
LIG1:POLB:dsDNA [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Rattus norvegicus)
PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Rattus norvegicus)
FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB:APEX1:SSB(5'ddRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
NEIL1:NEIL2:POLB:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Rattus norvegicus)
NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] (Rattus norvegicus)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:dsDNA [nucleoplasm] (Rattus norvegicus)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB-dsDNA [nucleoplasm] (Rattus norvegicus)
as an input of
Recruitment of POLB to the AP site (Rattus norvegicus)
Recruitment of POLB to oxidatively damaged AP site (Rattus norvegicus)
NEIL1,NEIL2 recruits POLB to incised AP site (Rattus norvegicus)
as an output of
PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Rattus norvegicus)
Other forms of this molecule
PolyUb-POLB [nucleoplasm]
Inferred From
POLB [nucleoplasm]
(Homo sapiens)
Cross References
ZINC - Investigational
DPOLB_RAT
ZINC - Metabolites
DPOLB_RAT
ENSEMBL
ENSRNOT00000113772
,
ENSRNOP00000094599
IntEnz
4.2.99.18
ZINC - Substances
DPOLB_RAT
ZINC - Biogenic
DPOLB_RAT
ZINC target
P06766
PRO
P06766
RGD
3363
ZINC - Predictions - Purchasable
DPOLB_RAT
PDB
3LQC
,
2VAN
,
3V72
,
1JN3
,
1HUZ
,
1NOM
,
3K75
,
3UXO
,
1ZQZ
,
1ZQY
,
1ZQX
,
3UXP
,
1BNP
,
1BNO
,
3UXN
,
3V7L
,
2BPC
,
3V7K
,
1HUO
,
1RPL
,
1ZQW
,
1DK2
,
1ZQU
,
1ZQV
,
1DK3
,
2BPG
,
3V7J
,
2BPF
,
1BPD
,
1BPE
,
1BPB
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P18887 XRCC1
1
XRCC1 [nucleoplasm]
(R-HSA-67455)
0.719
4
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