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Fadd [cytosol]
Stable Identifier
R-RNO-54639
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
FADD, Q8R2E7
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
Toll-like Receptor Cascades (Rattus norvegicus)
Toll Like Receptor 4 (TLR4) Cascade (Rattus norvegicus)
MyD88-independent TLR4 cascade (Rattus norvegicus)
TRIF (TICAM1)-mediated TLR4 signaling (Rattus norvegicus)
TRIF-mediated programmed cell death (Rattus norvegicus)
Caspase-8 processing within TLR4 complex (Rattus norvegicus)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
TLR4-induced ripoptosome assembly (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
Programmed Cell Death (Rattus norvegicus)
Apoptosis (Rattus norvegicus)
Caspase activation via extrinsic apoptotic signalling pathway (Rattus norvegicus)
Caspase activation via Death Receptors in the presence of ligand (Rattus norvegicus)
Caspase-8 processing within TLR4 complex (Rattus norvegicus)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
Dimerization of procaspase-8 (Rattus norvegicus)
FAS-mediated dimerization of procaspase-8 (Rattus norvegicus)
FASL:FAS receptor trimer:FADD:procaspase-8-dimer [plasma membrane] (Rattus norvegicus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Rattus norvegicus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
TNF-mediated dimerization of procaspase-8 (Rattus norvegicus)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Rattus norvegicus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
TRAF2:TRADD:RIP1:FADD:2xCASP8(1-479) [cytosol] (Rattus norvegicus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
TRAIL-mediated dimerization of procaspase-8 (Rattus norvegicus)
TNFSF10:TNFRSF10A,B:FADD:2xCASP8(1-479) [plasma membrane] (Rattus norvegicus)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] (Rattus norvegicus)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
Regulation by c-FLIP (Rattus norvegicus)
Caspase-8 and FLIP(L) processing at DISC (Rattus norvegicus)
DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Rattus norvegicus)
DISC [plasma membrane] (Rattus norvegicus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Rattus norvegicus)
DISC:procaspase-8 [plasma membrane] (Rattus norvegicus)
DISC [plasma membrane] (Rattus norvegicus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Rattus norvegicus)
FASL:FAS Receptor Trimer:FADD:pro-Caspase-8:FLIP(L) [plasma membrane] (Rattus norvegicus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Rattus norvegicus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Rattus norvegicus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Rattus norvegicus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Rattus norvegicus)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] (Rattus norvegicus)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479):CFLAR [plasma membrane] (Rattus norvegicus)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
Regulated Necrosis (Rattus norvegicus)
RIPK1-mediated regulated necrosis (Rattus norvegicus)
Regulation of necroptotic cell death (Rattus norvegicus)
CASP8 activity is inhibited (Rattus norvegicus)
FLIP(L) and procaspase-8 form heterodimer (Rattus norvegicus)
DISC:procaspase-8 [plasma membrane] (Rattus norvegicus)
DISC [plasma membrane] (Rattus norvegicus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Rattus norvegicus)
DISC:procaspase-8 [plasma membrane] (Rattus norvegicus)
DISC [plasma membrane] (Rattus norvegicus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
FLIP(S) and procaspase-8 form heterodimer (Rattus norvegicus)
DISC:procaspase-8 [plasma membrane] (Rattus norvegicus)
DISC [plasma membrane] (Rattus norvegicus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Rattus norvegicus)
DISC:procaspase-8 [plasma membrane] (Rattus norvegicus)
DISC [plasma membrane] (Rattus norvegicus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
RIPK1 is cleaved by CASP8 (Rattus norvegicus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Death Receptor Signaling (Rattus norvegicus)
FasL/ CD95L signaling (Rattus norvegicus)
FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Rattus norvegicus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Rattus norvegicus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
FasL:Fas binds FADD (Rattus norvegicus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
TNF signaling (Rattus norvegicus)
Regulation of TNFR1 signaling (Rattus norvegicus)
Caspase-8 and FLIP(L) processing at TNFR signaling complex (Rattus norvegicus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Rattus norvegicus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Rattus norvegicus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Rattus norvegicus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Rattus norvegicus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
RIPK1 is cleaved by CASP8 (Rattus norvegicus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
RIPK1 is cleaved by CASP8:FLIP(L) (Rattus norvegicus)
TRADD:TRAF2:RIPK1(325-671):FADD:p43/p41CASP8:p43 FLIP(L) [cytosol] (Rattus norvegicus)
TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Rattus norvegicus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
TNFR1-induced proapoptotic signaling (Rattus norvegicus)
TRADD:TRAF2:RIP1 binds FADD (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
TRAIL signaling (Rattus norvegicus)
TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Rattus norvegicus)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] (Rattus norvegicus)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
TRAIL:TRAIL receptor trimers bind FADD (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Rattus norvegicus)
Fadd [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q8R2E7
Gene Names
Fadd
Reference Genes
BioGPS Gene:266610 Fadd
ENSEMBL:ENSRNOG00000047035
KEGG:rno:266610 Fadd
Monarch:266610 Fadd
NCBI Gene:266610 Fadd
UCSC:Q8R2E7 Fadd
Reference Transcript
RefSeq:NM_152937.2 Fadd
Other Identifiers
10727228
1391199_at
17638868
266610
5747707
5912775
5953332
6021430
6029932
A_44_P258773
A_64_P097784
GE1139647
GO:0001916
GO:0002020
GO:0002376
GO:0002821
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006915
GO:0007155
GO:0007165
GO:0008625
GO:0012501
GO:0023052
GO:0030154
GO:0031264
GO:0031265
GO:0032729
GO:0032757
GO:0032760
GO:0032813
GO:0033077
GO:0035591
GO:0035877
GO:0036462
GO:0042104
GO:0042802
GO:0042981
GO:0043029
GO:0043065
GO:0043123
GO:0045651
GO:0045862
GO:0045944
GO:0048535
GO:0048536
GO:0048538
GO:0048856
GO:0048870
GO:0051607
GO:0060090
GO:0060340
GO:0060546
GO:0065003
GO:0070236
GO:0071260
GO:0071550
GO:0089720
GO:0097049
GO:0097190
GO:0097191
GO:0097192
GO:0097342
GO:0097527
GO:0098542
GO:1900119
GO:2000454
GO:2001238
ILMN_1352659
PH_rn_0008098
rc_AA819355_at
Participates
as a component of
TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] (Rattus norvegicus)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Rattus norvegicus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Rattus norvegicus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Rattus norvegicus)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Rattus norvegicus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Rattus norvegicus)
as an input of
FasL:Fas binds FADD (Rattus norvegicus)
TRAIL:TRAIL receptor trimers bind FADD (Rattus norvegicus)
TRADD:TRAF2:RIP1 binds FADD (Rattus norvegicus)
TLR4-induced ripoptosome assembly (Rattus norvegicus)
Inferred From
FADD [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_690920.1
ENSEMBL
ENSRNOP00000066289
,
ENSRNOT00000075089
RGD
628700
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9JHX4
6
Casp8 [cytosol]
(R-RNO-3465404)
Casp8 [mitochondrial outer membrane]
(R-RNO-351869)
Casp8 [mitochondrial outer membrane]
(R-RNO-351828)
Casp8 [cytosol]
(R-RNO-76158)
Casp8 [cytosol]
(R-RNO-75975)
Casp8 [cytosol]
(R-RNO-57031)
0.499
2
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